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Enabling oral drug formulations: mechanistic studies and modeling
Abstract The current drug discovery pipeline is flooded with challenging molecules, characterized by poor aqueous solubility and/or low permeability. This necessitates the use of “...
Spatiotemporal regulation of epigenetic silencing by macromolecular interactions
Summary The development of the human body involves cell specification and cell fate transition starting from the embryos. Precise coordination of gene expression networks is requir...
Defining developmentally regulated retroelement-based mechanisms to better understand and treat their dysregulation in disease.
Nearly half of all mammalian genomes originate from mobile sequences and ancient retroviruses called RetroElements (REs). REs consists of tens-of-thousands of nearly identical repe...
The integration of nutrient-specific satiety signals in the brain to control food intake.
PROJECT SUMMARY/ABSTRACT Most studies in the field of feeding regulation have primarily concentrated on the impact of energy homeostasis on feeding behavior, with less attention to...
Improving Drug Development Through Studies of Protein Kinase Inhibitors
Drug development is time consuming and costly with little certainty of eventually leading to an approved medicine. As new therapies are urgently needed, research is required to scr...
Supramolecular Strategies to Modulate Biomolecular Folding and Assembly
PROJECT SUMMARY Natural processes, such as protein expression, cell differentiation, and gene transcription, depend on biomolecules to adopt specific assembly states and secondary...
Biomedical Applications of Reactive Sulfur and Selenium Species: Diagnosis and Therapuetics
Project Summary/Abstract Reactive sulfur species (RSS), including hydrogen sulfide (H2S), persulfides (RSSH), and polysulfides (RSSnR, n>1), are endogenously expressed biomolecu...
Engineering cell-based therapy for enhanced survival and durable function in vivo
Project Summary The long-term goal of my lab is to develop durable cell-based therapies for treating various chronic diseases. Engineered cells secreting therapeutic proteins are g...
Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human Gut
Project Summary/Abstract A healthy human microbiome is intrinsically linked to vital physiological aspects such as development, immune function, and nutrition. The composition and...
Development and Evaluation of an Online Contraception Decision Aid for Transgender and Gender-Nonconforming (TGNC) Persons Assigned Female at Birth (AFAB)
PROJECT SUMMARY The objective of the proposed project is to develop and evaluate an online contraception decision aid, ContraceptionForAll, for transgender or gender-nonconforming...
Advancing Understanding of Genomic Mechanisms for Primary ADHD in Families
ABSTRACT The genetic mechanisms contributing to neurodevelopmental disorders are highly variable across children and families. This is especially true for attention-deficit/hyperac...
The brainstem vocal control circuits
Abstract Vocalization is used in many species for social and emotional communications. Interestingly, mice can emit two types of vocalizations: ultrasonic vocalizations during soci...
Proteomics and Genomics to Identify Therapeutic Targets for Ischemic Stroke Prevention
ABSTRACT As the global burden of ischemic stroke (IS) continues to rise due to population demographic shifts, new treatment approaches for stroke prevention are needed to address i...
Mechanisms and relevance of miRNA decay during hematopoietic development
PROJECT SUMMARY/ABSTRACT MicroRNAs (miRNAs) are essential regulators of the human transcriptome and play a central role in tissue development. As the hematopoietic system is compos...
Self-Assembled Multifunctional Biointerfaces
Research in the Zha Lab at Rensselaer Polytechnic Institute focuses on creating biomimetic materials and processes that aid in studying, diagnosing, preventing, and treating diseas...
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
PROJECT SUMMARY This project is a multi-site clinical trial of a transcranial magnetic stimulation-electroencephalography (TMS-EEG) device for diagnostic and prognostic use in crit...
Computational two-photon microscopy for deep tissue imaging
ABSTRACT Intravital microscopy has been widely employed to visualize the structures and functions of cells in their natural environment. However, the imaging depth of intravital im...
Convergent Evolution in Natural Product Biosynthesis
Abstract Natural products are non-essential small organic molecules produced by living organisms, such as bacteria, fungi, plants, and animals. They have been described as the most...
Understanding what regulates a regulator: the molecular basis for homeostatic small RNA-mediated gene regulation
PROJECT SUMMARY/ABSTRACT RNA interference (RNAi) pathways are critical regulators of cellular programs conserved across eukaryotes. Target-specific RNAi-mediated regulation for tho...
Ultrahigh-Sensitivity Mass Spectrometry for Scalable Proteomics
The protein composition of a cell, or proteome, responds dynamically to external and internal environments, and provides fundamental information on biomolecular mechanisms. However...