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Cellular and Molecular Determinants of Post-Burn Myopathy
ABSTRACT Severe burn trauma triggers profound muscle atrophy and weakness which persists for years post- injury. To date, research efforts have predominantly explored hypermetaboli...
Targeting angiotensin and inflammation to prevent radiotherapy-induced bladder toxicity.
ABSTRACT/SUMMARY Radiotherapy (RT) is an effective treatment modality for pelvic malignancies. However, radiation cystitis (RC) is a widely recognized irreversible and chronic cond...
A Pragmatic Randomized Controlled Trial to Evaluate the Effectiveness of an Intervention to Promote Guideline-Concordant Colorectal Cancer Surveillance
ABSTRACT The transition from curative-intent treatment to survivorship can be an overwhelming and confusing time for patients with colorectal cancer (CRC). Surveillance for cancer...
Ligand Gated Ion Channels Across Time and Space
PROJECT SUMMARY Ligand-gated ion channels (LGICs) enable cells to fine-tune their intracellular space based on environmental cues and cell-cell communication. Because of their role...
Expanding Access to Molecular Complexity through Natural Product Synthesis
The development of modern medicines relies on the ability to access compounds that are potent, selective, and ideally curative. To achieve these goals, chemists have sought to prep...
Understanding prion-mediated transcriptional modifications and cellular phenotypes: insights into the role of Swi1 prion and prion-like behaviors of BAF proteins
The term "prion" was originally coined to describe the agent responsible for neurodegenerative diseases associated with the prion protein, PrP. This concept has now broad...
Modulation of Endoplasmic Reticulum Associated Degradation to Support Ex Vivo Expansion of Hematopoietic Stem Cells
Abstract Long-term hematopoietic stem cells (LT-HSCs) extensively self-renew to maintain the pool of HSCs for a lifelong blood production and differentiate to generate all mature b...
Quantitative Molecular Imaging in Engineered Cellular Microenvironments to Study and Control Directional Mechanosensing
PROJECT SUMMARY Directional sensing of force plays a critical role in a wide variety of physiologic processes including migration, angiogenesis, morphogenesis, and mechanical homeo...
Mechanisms of Wnt ligand specific signaling in the development of blood-retina barrier and blood-brain barrier
Canonical Wnt signaling plays a crucial role in several vital processes, including neural tube and retinal vascularization, as well as the maintenance of the blood-brain barrier (B...
Determining how membrane fluidity regulates embryonic cell migration
PROJECT SUMMARY/ABSTRACT Cells first interact with their environment through the plasma membrane where diverse interactions between lipids and proteins organize membrane complexes...
Developing Selective Inhibitors and Probes for Concentrative Nucleoside Transporters
ABSTRACT: Nucleoside transporters (NTs) mediate the cellular transport of physiological nucleosides and many synthetic derivatives like the reverse transcriptase inhibitors (NRTIs)...
Genomic Analysis of Inherited Breast and Ovarian Cancer
The discovery of BRCA1 and BRCA2 and other genes of homologous recombination repair, and the characterization of the roles of these genes in inherited predisposition to breast and...
Innate immunomodulation of retinal neovascularization
Project Summary Proliferative retinopathies, characterized by the growth of pathological blood vessels (neovessels), are the leading causes of blindness in all age groups. Retinopa...
Dissecting the role of DNA methylation in controlling retrotransposons and governing adult stem cell fates
Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotes. The mammalian genome undergoes tightly regulated global demethylation early development where fa...
Computational framework to investigate the inorganic ion transporters
Abstract Transmembrane transporters play a critical gatekeeper role in determining and controlling the intracellular concentration of ions, nutrients, toxins, or drugs in all cells...
Proteostasis and Phosphate Sensing in the Regulation of the Phosphate Transporter SLC20A1
PROJECT SUMMARY / ABSTRACT The mechanisms by which mammalian cells sense phosphate availability to maintain homoestasis of this critical nutrient are unknown. Phosphate is indispen...
A pericyte Cl- clamp controls capillary electrical signaling and brain blood flow
Neurons lack substantial energy stores and thus their function is critically dependent on the timely delivery of energy substrates in the blood. Precise control of brain blood flow...
MIRA R35: Fibrin(ogen) in regulating health and disease
PROJECT SUMMARY/ABSTRACT Fibrin(ogen) plays a critical role in processes such as wound healing, coagulation, cancer, pregnancy, and inflammation. Fibrin(ogen), which is a blood pla...
Dissecting the molecular mechanism of cytokine activation and spatiotemporal regulation of innate immunity
PROJECT SUMMARY AND ABSTRACT Macromolecular signaling complexes play fundamental roles in biology, ranging from the control of development to regulation of the immune system. The i...
Complementary Biotherapeutic Delivery Platforms for Enabling Gene Re-delivery
Complementary Biotherapeutic Delivery Platforms for Enabling Gene Re-delivery Project Summary Facing the universal challenge of re-delivering Adeno-associated viruses (AAVs), our p...