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99,167 grants found
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Connecting epigenetic programming of T cells with molecular traits of the immune system in health and disease
PROJECT SUMMARY Identifying causal disease variants and elucidating how they lead to chronic disease remain important challenges in medicine. Genome-wide association studies have s...
Homeostasis of one-carbon metabolism to support epigenetic methylation
Project Summary/Abstract Overview: The methylation of DNA and histone tail residues tunes chromatin structure to control gene expression programs. Methionine supplies one-carbon (1...
The evolutionary and genomic drivers of mutation spectra
Project summary: The evolutionary and genomic drivers of mutation spectra. Patterns of spontaneous mutation vary widely, but there is currently no consensus as to how selection and...
Homeostasis of the Retinal Epigenome
PROJECT SUMMARY / ABSTRACT DNA encodes all of the information required to generate and maintain each cell within the body. However, DNA alone is not sufficient and requires the gen...
Impact of State Cannabis Laws on Cancer Pain Management and Outcomes: A mixed-methods study
PROJECT SUMMARY/ABSTRACT More than one third of the approximately 2 million Americans diagnosed with cancer each year experience moderate to severe pain related to their disease an...
Elucidating Mechanisms and Design Principles for Chemically Inducible Expression Modulation
PROJECT SUMMARY Molecular tools that can precisely modulate gene expression provide unique opportunities to both study the relationships between genotype and phenotype, as well as...
Effectiveness of text-based support for parents of suicidal adolescents following emergency department visits
PROJECT SUMMARY Emergency department (ED) visits for suicidal ideation and attempts in adolescents are rising, underscoring a need for effective interventions preventing post-ED re...
Mechanisms of neutrophil extracellular trap formation and contribution to biliary fibrosis in biliary atresia
PROJECT SUMMARY/ABSTRACT Biliary atresia (BA) is an inflammatory, sclerosing lesion of the biliary tree that presents in infancy and is associated with significant biliary fibrosis...
Regulation and Function of Biomolecular Condensate
Project Summary A fundamental question in cell biology is how this crowded space can be organized to enable the control of biochemical processes and reactions in space and time. Bi...
Adolescent Mental Health and the Role of Medicaid Managed Care
PROJECT SUMMARY The United States faces an unprecedented mental health crisis among children and adolescents. In 2021, 29% of high school students reported experiencing poor mental...
Activated Protein C Signaling in Aging
Project Summary Alzheimer’s disease (AD) is the most common form of dementia and is becoming a national health crisis as the sixth leading cause of death in the United States. Prom...
Serum PFAS and risk of fracture and bone loss
PROJECT SUMMARY With aging of the U.S. population, the burden of osteoporotic fractures will increase well beyond the current estimate of 2 million per year and $17 billion cost. T...
Determining the links between alcohol use, firearm access and suicide risk
PROJECT SUMMARY/ABSTRACT Nearly 60% of firearm-related deaths are suicides, and over half of suicide deaths involve firearms. Further nearly half of firearm suicide decedents were...
Proof-of-concept for the use of enzyme replacement therapy as a lifesaving treatment for sphingosine phosphate lyase insufficiency syndrome
PROJECT SUMMARY SPLIS is an ultra-rare, often lethal inborn error of metabolism recognized just five years ago. Most affected children exhibit a rapidly progressive form of nephrot...
Statistical methods and analyses to study genetic variants and their roles in diseases leveraging functional genomics data.
Project Summary Common genetic variation is an important player in human diseases. One central goal of human genetic studies is to identify causal genetic variants in diseases and...
Role of Cytoskeletal Motor Proteins in Subcellular RNA Localization
ABSTRACT Cells are exquisitely-organized entities, with the location of biomolecules within intimately tied to the maintenance of the organism and the regulation of its genes. Wher...
Combining experimental evolution and molecular phenotyping to understand variation in organismal phenotypes
PROJECT SUMMARY Understanding the forces that shape patterns of genetic and phenotypic variation in populations is a central goal of evolutionary biology. Within a biomedical conte...
Effective treatment of cystinuria with a novel engineered cyst(e)ine-degrading human enzyme therapy
Project Summary Cystinuria is a rare disease characterized by chronic, recurrent lithiasis (stone formation) in the urinary tract due to accumulation of high concentrations of cyst...
Hybrid Effectiveness-Implementation Trial of a Nurse-Led Firearm Safety Intervention in the Pediatric Inpatient Setting
PROJECT SUMMARY The proposed study aims to reduce firearm-related deaths in children by scaling out an evidence-based secure firearm storage intervention. The rate of firearm-relat...
Constructing 3D voxelated tissues with molecular architecture encoded modular biomaterials to understand and control stem cell function
PROJECT SUMMARY Most biological tissues are not simply static materials but active living composites. They are composed of living cells dispersed in nonliving polymers known as ext...