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99,167 grants found
Showing 381 – 400 of 99,167 grants
Psychometric Reliability and Validity for Behavioral Metrics of Osteoarthritic Pain in Horses
Project Summary Historically, osteoarthritis (OA) pathology is defined by the breakdown of articular cartilage. While cartilage loss remains a hallmark of OA, the pathology of OA i...
Development of an in vivo model system of sensory afferent neuron regeneration
Project Summary The afferent neurons of the eighth cranial nerve transmit information from the cochlea and vestibular organs to the brainstem. These neurons can be lost following d...
Functional Interrogation of Type 2 Diabetes-associated Genetic Network
Abstract. Type 2 diabetes (T2D) is a polygenetic disease marked by impaired insulin secretion in pancreatic islet cells. Although genome-wide association studies (GWAS) have identi...
Sustaining Home Palliative Care for Patients with Heart Failure (HF) and Their Family Caregivers in Rural Appalachia: A Mixed Methods Randomized Clinical Trial (RCT)
Project Summary Heart failure (HF) is the leading cause of mortality, morbidity, and rehospitalizations in Appalachia. Rural areas have the highest HF mortality rates. West Virgini...
Decoding FTIR-based multimodal imaging for risk assessment of precancerous oral lesions
PROJECT SUMMARY/ABSTRACT Successful treatment and management of oral mucosal lesions depend on a definitive, accurate, and timely diagnosis. Oral squamous cell carcinoma (OSCC) is...
Improving Measurement and Documentation of Long-term Neighborhood Change and Racial Segregation
PROJECT SUMMARY/ABSTRACT This is a study of neighborhood racial change and its impacts on trends in Black-white segregation over a multi-decade time span. It will provide much new...
Leveraging youth sports practices to increase physical activity among racial and ethnic minority mothers
Project Summary Women with racial and ethnic minority identities, specifically Hispanic and Black women exhibit suboptimal physical activity-related behaviors and are disproportion...
Gain-sensitive cochlear microphonics - a diagnostic test of functional and physiological effects of sensory hearing loss
PROJECT SUMMARY According to the Centers for Disease Control, hearing loss is the third most common chronic physical condition in the US, surpassing diabetes, and cancer in prevale...
Efficacy of Novel Melanocortin and Gut-peptide Dual Agonists for Childhood Obesity Treatment
SUMMARY The high prevalence of pediatric obesity requires new anti-obesity agents with increased efficacy, safety, and tolerance. Recent treatments based on endogenous gut peptides...
BMAL1 Circadian Clock Complexes from Mammalian Brain
Project Summary The circadian clock is an endogenous ~24-hour oscillator that drives daily rhythms of biological processes. In mammals, circadian clocks are found in the brain and...
Bioactivity of CAR T cells secreting T cell engager-anitbodies in humans with glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is a deadly brain tumor with limited treatment options. We have developed a promising new treatment for GBM using chimeric antigen receptor (CAR)...
Reducing falls with Varenicline in Hypocholinergic Parkinson disease
Falls are a major problem for people with Parkinson disease (PD).Falls and their sequelae are the leading cause of hospitalizations, precipitate institutionalization, and increase...
Multiplex Ultrasound Imaging for the Detection of Head and Neck Lymph Node Micrometastases
Project Summary Determining whether a tumor has spread to the regional lymph nodes is critical for staging and treatment planning for several types of cancer, including cancers of...
Video Inspired Discussions about Ethical Outcomes in Pediatrics (VIDEO-PEDS)
Parents of children with cancer often face complicated decision making throughout their child’s illness. Goals-of-care (GOC) interventions help patients, their families, and clinic...
Improving PGS Prediction for Underrepresented Groups Through Transfer Learning
In the last two decades, thousands of Genome-Wide Association Studies (GWAS) have been published. Increasingly, the findings reported by these studies inform the development of Pol...
Penn-DISAM: Data Integration and Statistical Analysis Methods for dGTEx Data
Abstract Our health and wellbeing prenatally and during the earlier years of life affect all future health and disease risks. This time period is the most sensitive for a child’s d...
CREBRF and risk of pregnancy and postpartum dysglycemia in American Samoan women
PROJECT SUMMARY As many as 42% of American Samoan women develop gestational diabetes (GDM) in pregnancy, which substantially elevates their risk of progressing to Type 2 diabetes (...
Endolysosomal Proteome Landscapes Through the Lens of Neurodegenerative Risk Alleles
The endolysosomal/Golgi system provides routes for degradation or recycling of plasma membrane (PM) proteins via endocytosis and degradation of cytosolic proteins/organelles via au...
Regulating Skeletal Connectivity in Craniofacial Development and Disease
PROJECT SUMMARY The craniofacial skeleton is composed of multiple tissue types that must be precisely integrated during development to ensure normal structure and function. While t...
Targeted Realtime Assessment of Chronic Pain (TRAC-Pain) in Youth
Chronic MSK pain is marked by a complex biologic response accompanied by physiological perturbance in cognition, sleep, and energy levels (fatigue), and is associated with impairme...