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99,167 grants found
Showing 21 – 40 of 99,167 grants
Mucosal B-cell aging in PLWH
PROJECT SUMMARY/ABSTRACT Overall, the world population is aging and in the era of anti-retroviral therapy (ART) people living with HIV (PLWH) live longer. ART has converted HIV inf...
A Translatable Form of Hypoxia Therapy for Impaired Mitochondrial Proteostasis
PROJECT ABSTRACT Our previous work demonstrated that hypoxic breathing, simulating high-altitude living, can prevent and reverse neurological damage in a mouse model of mitochondri...
Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Project Summary: Heart failure with preserved ejection fraction (HFpEF) has emerged as the greatest unmet medical need in cardiovascular medicine, comprising 50% of all HF cases, w...
C5ORF51 - a Novel Regulator of Cardiomyocyte Function and Homeostasis
PROJECT SUMMARY / ABSTRACT Adult human cardiomyocytes have poor capacity for proliferation and functional recovery after heart attack, thus leading to the high morbidity and mortal...
Cerebrovascular O-GlcNAcylation Worsens Diabetes-associated Neurovascular Injury and Recovery Post-stroke
PROJECT SUMMARY Diabetes affects more than 463 million people worldwide and significantly increases the risk of stroke, as well causing greater neurovascular injury in response to...
Mechanisms of Lamin A/C-mediated Cardiac Conduction Disorders
PROJECT SUMMARY The cardiac conduction system (CCS) is specialized in the generation and propagation of electrical impulses from the atria to the ventricles to produce a highly coo...
Mapping Synaptic Density in Prodromal and Manifest Lewy Body Dementia
Project Summary Synaptic loss is theorized to occur early in the course of common neurodegenerative proteinopathies such as Alzheimer disease (AD) and Lewy body dementia (LBD). Unt...
Investigation of the Functional Roles of MicroRNA-320 in Skeletal Muscle
PROJECT SUMMARY/ABSTRACT Disuse, denervation, and several diseases result in skeletal muscle atrophy and weakness – a major contributor to disease-related disability and death. The...
Neuroimmune Genomic Profiling of Alzheimer's Disease
Summary Molecular-genetic studies have illuminated the primary pathway of Alzheimer’s disease (AD). However, a relatively long chronic prodromal period of the disease, and the casc...
Vagal-hypothalamic modulation of alcohol intake
Abstract Alcohol use disorder (AUD) is the third leading cause of preventable death in the U.S. and 32.6 million adults have AUD. AUD etiology is highly diverse and current treatme...
Dynamic nanoscale cellular imaging via time-resolved cryo-vitrification
Summary: Many cellular processes are triggered by ligands such as ions, small molecules, peptides/proteins (e.g., hormones, cytokines), and viruses. However, rapid cellular adaptat...
Influence of early life physical inactivity during a key period of postnatal development on adult muscle quality – from matrix to mortality
Project Summary The physical inactivity (PIA) epidemic has far-reaching negative health impacts on adults, but even more so on children, who are facing more PIA than ever in divers...
FIU-Diversity Center for Genomic Research (FIU-DCGR)
FIU Diversity Center for Genomic Research (FIU-DCGR) Abstract Florida International University (FIU) is in Miami-Dade County, Florida, a county with a population of 2.7 million (20...
Role of Brain Aromatase in Alzheimer's Dementia: Sex differences and the Preventive Therapy using Pulsed Photobiomodulation
Abstract Alzheimer's disease (AD) is a growing global health concern that disproportionately impacts women. Additionally, patients with aromatase/estrogen receptor inhibitors...
Manganese exposure and genetic diversity in risk mechanisms for neurodevelopmental disorders
ABSTRACT The broad, long-term objectives of the grant are to increase our understanding of the mechanisms underlying the gene x environment interactions that link developmental man...
Osteogenesis imperfecta caused by TMEM38B mutation: a deep investigation of cellular and extracellular consequences to identify new therapeutic targets
Project Summary There is no cure for osteogenesis imperfecta (OI or brittle bone disease), a group of heritable genetic disorders affecting 1:15,000 births. The most evident clinic...
Intranasal Insulin Administration as Medication for Alcohol Use Disorder
SUMMARY/ABSTRACT While there have been developments in treatments for alcohol use disorder (AUD), current pharmacotherapies face several limitations, including the presence of adve...
Genomic encoding of heterogeneity
Project Summary/Abstract In development, the embryo generates many cell types with distinct gene expression programs, leading to heterogeneity across cells. In cancer, mutation gen...
Harnessing multi-omics to identify host-microbiome interactions driving HIV-associated chronic obstructive pulmonary disease in low and middle income countries.
ABSTRACT Chronic obstructive pulmonary disease (COPD) affects 300 million people and is the third leading cause of death globally, with >80% of these deaths occurring in low- an...
Guided Intracellular Delivery using Precise Area Introduction and Transfection (PAINT)
PROJECT SUMMARY The objective of the proposed project is to develop a method called PAINT (Precise Area INtroduction and Transfection) for highly localized, versatile, and efficien...