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99,167 grants found
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ADRC Consortium for Clarity in ADRD Research Through Imaging
PROJECT SUMMARY Alzheimer’s disease (AD) pathophysiology seldom occurs in isolation, and it is widely established from the neuropathology literature that the majority of individu...
The Alzheimer's Disease Tau Platform Clinical Trial
PROJECT SUMMARY / ABSTRACT Tau protein is an attractive AD therapeutic target because the amount and anatomical distribution of insoluble tau at autopsy is strongly correlated wi...
ADRC Consortium for Clarity in ADRD Research Through Imaging
PROJECT SUMMARY Alzheimer’s disease (AD) pathophysiology seldom occurs in isolation, and it is widely established from the neuropathology literature that the majority of individu...
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
Project Summary/Abstract The University of South Florida is uniquely qualified to conduct the activities specified in this limited competition RFA. The purpose of the RFA is to fun...
The Health & Aging Brain Study - Health Disparities (HABS-HD)
HABS-HD OVERALL ABSTRACT The 2018 AT(N) framework provided the field with the first biological conceptualization of Alzheimer’s disease (AD) for the explicit purpose of advancing...
The Health & Aging Brain Study - Health Disparities (HABS-HD)
HABS-HD OVERALL ABSTRACT The 2018 AT(N) framework provided the field with the first biological conceptualization of Alzheimer’s disease (AD) for the explicit purpose of advancing...
The Health & Aging Brain Study - Health Disparities (HABS-HD)
HABS-HD OVERALL ABSTRACT The 2018 AT(N) framework provided the field with the first biological conceptualization of Alzheimer’s disease (AD) for the explicit purpose of advancing...
ACE Covid 19 Admin Supplement: Molecular Regulation of B cells and T cells in Human SLE
COVID 19 Vaccination Trial (ACV01) Emory requests an Admin Supplement (AS) to support the ACE COVID-19 vaccination trial (ACV01) and study. Below, first the major components are li...
Education and Cognitive Functioning in Later Life: The Nation’s High School Class of 1972
PROJECT SUMMARY/ABSTRACT Education is among the most important determinants of later-life cognitive functioning and biological markers of AD/ADRD risk. However, we know very litt...
Center for Multiomic Human Brain Cell Atlas
Abstract Understanding cell identities and their spatial distributions throughout different regions of the human brain is a fundamental step when trying to integrate physiologica...
Functionally guided adult whole brain cell atlas in human and NHP
Progress in treating brain disorders has been frustratingly slow, in large part due to the extraordinary complexity of the human brain and its inaccessibility to study. Remarkable...
AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections
Project Summary The AIDS Clinical Trials Group (ACTG) has been at the forefront of clinical research to advance HIV therapeutics and improve the health of people living with HIV/AI...
Immune Tolerance Network
Project summary / ABSTRACT The mission of the ITN is to advance the clinical application of immune tolerance by performing high quality clinical trials of emerging therapeutics bas...
UTMB-Novartis Alliance for Pandemic Preparedness
OVERALL – ABSTRACT Pandemic prevention and preparedness is a major scientific and societal priority that requires sustained and forward looking investments across governmental, n...
An Expanded Access Protocol of Intravenous Trehalose Injection 90 mg/mL Treatment of Patients with Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative. There are two FDA-approved medications to slow ALS progression, riluzole and edaravone; their effec...
Center for Multiomic Human Brain Cell Atlas
Abstract Understanding cell identities and their spatial distributions throughout different regions of the human brain is a fundamental step when trying to integrate physiologica...
Design and Development of a Pan-betacoronavirus Vaccine
Abstract - Overall Compared to SARS-CoV-1 and MERS, the current SARS-CoV-2 virus is highly transmissible and to date has caused over 85,000,000cases worldwidewith over 1,800,000 de...
Functionally guided adult whole brain cell atlas in human and NHP
Progress in treating brain disorders has been frustratingly slow, in large part due to the extraordinary complexity of the human brain and its inaccessibility to study. Remarkable...
Functionally guided adult whole brain cell atlas in human and NHP
Progress in treating brain disorders has been frustratingly slow, in large part due to the extraordinary complexity of the human brain and its inaccessibility to study. Remarkable...
ED-LEAD: Emergency Departments LEading the transformation of Alzheimer's and Dementia care
PROJECT SUMMARY In persons living with dementia (PLWD), an Emergency Department (ED) visit is a critical event and an opportunity to address the unmet needs that preceded the vis...