Browse All Grants
99,167 grants found
Showing 3,961 – 3,980 of 99,167 grants
Evaluation of a Proactive Identification and Digital Mental Health Intervention Approach to Address Unmet Psychosocial Needs of Individuals Living with Likely Incurable Cancer
ABSTRACT Individuals living with likely incurable cancer (ILLIC) are a heterogeneous, growing subpopulation of cancer survivors who have unique survivorship care needs. Principal a...
Numerical Experimentation of the Therapeutic Effect of Excess Glucose Transglycosylation and Optimization in the Proximal Small Intestine.
Project Summary/AbstractThe Gastrointestinal (GI) system engages the coordinated function of digestive organs, oxygenated blood supply, nutrientprocessing and distribution, detoxif...
Social Media Use and Mental Health among Racially/Ethnically Minoritized Adolescents
PROJECT SUMMARY Mental health problems among U.S. adolescents have risen precipitously in the past decade, along with social media use, now a staple of adolescent communication and...
Novel biologic RNA molecules to modulate HCC metabolism
PROJECT SUMMARY Liver cancer is a major cause of cancer-related deaths within the United States, being the fifth and seventh leading cause of cancer deaths among men and women, res...
New Methods and Strategies for the Scalable Synthesis of Complex Bioactive Molecules
Abstract To enable reliable access to meaningful quantities of bioactive natural and unnatural compounds with higher complexity, it is vital to devise new synthesis logics and deve...
3D dynamic contrast optical coherence microscopy for organoid studies
PROJECT SUMMARY Optical coherence tomography (OCT) is an emerging biomedical imaging technology that provides label-free and depth-resolved images with micron-scale spatial resolut...
Investigating CXCR3 Blockade as Precision Therapy for Cardiac Sarcoidosis using Single-Cell Multi-omics and TCR Phenotyping
PROJECT SUMMARY/ABSTRACT Sarcoidosis, characterized by non-caseating granulomas, is a multi-organ inflammatory disease disproportionately affecting black patients in the United Sta...
Computational methods for in situ spatial transcriptomics
Project Summary/Abstract The explosive growth of spatial transcriptomics technologies has revolutionized the study of tissue spatial architecture and development. In contrast to mi...
Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer
Pain, fatigue, and distress are highly prevalent co-occurring symptoms in patients with advanced cancer. When these symptoms interfere with patients’ daily lives, it can diminish t...
Understanding host-microbiome coevolution and genetic variation in immunity using an insect model system
PROJECT SUMMARY / ABSTRACT Microbiomes have been described as ‘ecosystems on a leash,’ because immunological control of the microbiome is critical for host health. Variation in the...
Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients
Cancer patients undergoing hematopoietic stem cell transplant (SCT) face numerous challenges because of this treatment’s toxicity, lengthy hospitalization and recovery, and persist...
Central modulation-paired motor rehabilitation for recurrent laryngeal nerve injury
PROJECT SUMMARY/ABSTRACT Recurrent laryngeal nerve (RLN) injury causes vocal fold motion impairments (e.g., vocal fold paralysis). The inability to adduct (close) the vocal folds h...
Gene regulation and the genetic basis of complex traits
PROJECT SUMMARY Understanding the genetic variation that underlies differences in survival and reproduction is essential to the study of biology and human disease. While most studi...
Bioengineering of Customized Exosomes as a Cell-free Therapy for Volumetric Muscle Loss Injuries Proposal
Project Summary/Abstract Volumetric Muscle Loss (VML) is the most devastating and chronic musculoskeletal injury in which a substantial amount of muscle is lost due to trauma or su...
Population genetics of human evolutionary history and natural selection
Project Summary This proposed research addresses unresolved and fundamental questions in human evolutionary history and the formation of genetic diversity. It contains three relate...
Developing new biophysical models of choroid fissure closure in zebrafish and foveal pit formation across species
PROJECT SUMMARY The proposed project is a physics and biology collaboration at the University of Northern Colorado (UNC) to model morphogenesis processes in the developing vertebra...
The urinary microbiome and bladder toxicity after pelvic radiotherapy
Project Summary: Most men diagnosed with prostate cancer (PCa) are 65-years of age or older. Radiotherapy (RT) is an effective and curative treatment for early-stage PCa. However,...
Regulation and Mechanisms of ER Proteostasis
ABSTRACT The endoplasmic reticulum (ER) plays a pivotal role in maintaining protein homeostasis by implementing crucial quality control mechanisms. Newly synthesized polypeptides t...
Economic Stressors and Opportunities as Influences of Emerging Adult Oral Health
PROJECT SUMMARY/ABSTRACT Oral diseases are among the most common chronic conditions of humankind; their origins can often be traced to socioeconomic and behavioral circumstances mu...
Investigating regulators of bacterial chromosome organization
PROJECT SUMMARY Chromosomes must be highly packaged to fit with cells. Modern tools like 3D chromosome capture allow for visualization of chromosome organization but are limited in...