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Survivorship in Patients with Multiple Myeloma Treated with Chimeric Antigen Receptor T-cell Therapy
PROJECT SUMMARY/ABSTRACT Multiple myeloma is the second most common hematologic cancer in the US and remains incurable, with virtually all patients developing relapsed or refractor...
Molecular Mechanisms of Immune Thrombocytopenia in Transfusion Medicine
OVERALL COMPONENT – PROJECT SUMMARY/ABSTRACT This revised application for a Program Project seeks support for a coordinated, multi-disciplinary investigation of molecular mechanism...
Administrative Core A
SUMMARY The Administrative Core is located within the administrative offices of the Blood Research Institute, the research arm of Versiti Blood Center of Wisconsin, and serves as t...
Protein Production, Structural Biology, and Nucleic Acid Sequencing and Analysis
CORE B SUMMARY This Program Project focuses on a group of closely related and clinically important antibody-mediated thrombocytopenias in which β3 integrins (αIIbβ3, αVβ3, and sing...
The Immunobiology of Fetal/Neonatal Alloimmune Thrombocytopenia
ABSTRACT/SUMMARY Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT), is a non-malignant hematologic bleeding disorder that arises when maternal antibodies specific for fetal platel...
The Immunobiology of Heparin-Induced Thrombocytopenia
ABSTRACT Heparin-induced thrombocytopenia (HIT) is an immune reaction caused by antibodies (Abs) that target platelet factor 4 (PF4) when bound to heparin (H) or other glycosaminog...
The Immunobiology of Vaccine-induced Immune Thrombotic Thrombocytopenia
ABSTRACT Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a complication of adenoviral (AdV)-based COVID-19 vaccination. Antibodies (Abs) against the 70-aa chemokine, p...
Central nervous system mechanisms and treatment response in chronic ocular surface pain
ABSTRACT Chronic ocular surface pain (COSP) affects approximately 5-15% of the US population at some time in their lives at an estimated cost of over $55 billion annually. People w...
BCOR Regulation of Venous Thromboembolism
PROJECT SUMMARY/ABSTRACT: Venous thromboembolism (VTE) is a major cause of morbidity and mortality. VTE is caused by acquired and genetic factors, but the genetic factors that modi...
Combinatorial design of nonviral base editing systems for treating cystic fibrosis with nonsense mutations
PROJECT SUMMARY Cystic fibrosis (CF) is a debilitating genetic disorder that predominantly impacts the lungs and pancreas due to mutations in the cystic fibrosis transmembrane cond...
Harnessing naturally occurring cell type-specific regulatory elements and normal HSC hematopoiesis to develop cell lineage-controlled CAR expression and continuously renewing CAR NK cells
Project Summary CAR T cell therapies have been revolutionary for patients with relapsed/refractory hematologic malignancies; however, the relapse rates are unacceptably high, with...
Regulation of lymphatic muscle cell function by store operated calcium entry signaling
PROJECT SUMMARY Secondary lymphedema poses a significant financial and health burden afflicting 1 in 1000 Americans, resulting in a debilitating and incurable swelling and fibrosis...
A Randomized Controlled Trial of Gamification and Social Incentives to Increase Adherence to Physical Activity Among Patients with Heart Failure with Preserved Ejection Fraction
PROJECT SUMMARY/ABSTRACT Heart failure with preserved ejection fraction (HFpEF), a syndrome characterized by exercise intolerance due to breathlessness and fatigue, is a major publ...
Identifying Multi-Level Predictors and Outcomes of Oral Anticancer Medication Adherence Initiation and Persistence among Patients with Hematologic Malignancies
Oral anticancer medications (OAM) are becoming standard of care for growing numbers of patients. Multiple myeloma (MM), chronic myeloid leukemia (CML), and chronic lymphocytic leuk...
The role of BCAM-positive cells in central cornea, limbus and conjunctiva
PROJECT SUMMARY/ABSTRACT A transparent cornea that maintains its architecture and refracts light is essential for visual acuity. Despite advances in corneal wound healing, individu...
Rapid and Ultrasensitive aptamer-based detection technologies for T. pallidum
ABSTRACT Infections with Treponema pallidum, the causative agent of syphilis, have been rapidly rising in the United States over the past decade and present an increasing threat to...
Reversible male contraception by inhibition of serine/threonine kinase 33
PROJECT SUMMARY The overarching objective of this new R01 grant proposal is to perform preclinical drug development studies to create potent, selective, metabolically stable, and p...
The Genetic and Epigenetic Interplay of Cocaine Addiction: A Cell-Type, Circuitry, and Functional Dissection
PROJECT SUMMARY The intricate orchestration of genetic and epigenetic dynamics in neurobiological systems plays a central role in substance use disorders (SUDs), with cocaine use c...
PRL3 inhibitors as migrastatics and the molecular determinants of PRL3 druggability
Project Summary More than 90% of cancer mortalities are associated with metastasis. Despite advances in cancer therapies, there has not been significant progress in metastasis-asso...
Heart Digital Twin Analysis of Arrhythmias due to Infiltrating Adiposity
PROJECT SUMMARY Sudden cardiac death due to ventricular arrhythmias (VAs) is a leading cause of mortality world-wide. Despite advancements in anti-arrhythmia therapies, VA rates re...