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99,167 grants found
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Development of A Directed Evolution Platform for RNA Methyltransferases.
PROJECT SUMMARY N6-methyladenosine (m6A) is one of the most abundant chemical modifications in human messenger RNA (mRNA). m6A in mRNA is dynamically regulated by the effector prot...
Develop and validate demineralized bone paper-based human bone metabolic and senolytic assays
Project Summary Bone metastasis is a major cause of morbidity and mortality in cancer survivors. It is closely linked to advanced skeletal aging, which is driven by the accumulatio...
Impact of the New York State Medicaid Value-Based Payment Model on Opioid Use Treatment and Equity
PROJECT SUMMARY _RY_ ____ _ Value-Based Payment (VBP) policy, which incentivizes care quality and cost savings instead of volume-based care, remains under-studied concerning popula...
Nucleic acid-containing immune complexes and immune activation
PROJECT SUMMARY/ABSTRACT The long-range goal of this research is to explore how HIV-1, when suppressed by anti-retroviral therapy (ART), sustains the immune activation and conseque...
Optimizing implementation of long-acting injectable PrEP
PROJECT SUMMARY HIV incidence is unacceptable with the availability of highly effective, evidenced-based methods of treatment and prevention. Biomedical HIV prevention has extended...
Accelerated Rosette Trajectories- Based 5D MR Spectroscopic Imaging AND MR Imaging of Myelin Fraction in Perinatally HIV-Infected Adults
PROJECT SUMMARY Better understanding is needed regarding the mechanism of HIV pathogenesis to the developing brain in individuals receiving longstanding antiretroviral therapy (ART...
Intersection of Periodontitis with HIV-Antiretroviral Therapy-Induced Immune Reconstitution Bone Loss, on Alveolar Bone and Tooth Loss, in People Living with HIV
PROJECT ABSTRACT This work is anchored on the findings by our group, and others, showing that prior to treatment, the HIV virus inflicts bone mineral density (BMD) loss in People l...
Reducing hazardous alcohol use and optimizing treatment as prevention among men living with HIV in risk environments
PROJECT SUMMARY Heavy and hazardous alcohol use is inextricably linked to the HIV epidemic in fishing communities on Lake Victoria in Uganda. Among men living with HIV (LWH) in fis...
Role of proteolytic extracellular vesicles in halogen gas dependent chronic lung injury
Exposures to chlorine (Cl2) or bromine gas (Br2) may occur during industrial accidents and in the military arena. Acute lung injury (ALI), followed by chronic lung injury (CLI) cha...
Health Equity and Access to Leverage Technology for Improved Diabetic Retinopathy Outcomes (HEAL-DR)
Project Summary/Abstract: In the United States, diabetes (DM) impacts 37.3 million people (11.3% population) and 96 million people aged 18-years or older have prediabetes (38.0% of...
Tunable multi-timescale cortical dynamics: fundamental theory and practical tools
Healthy cerebral cortex function requires population neural activity that is coordinated across a wide range of timescales. Neural circuits must operate with quick, momentary senso...
Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center
Overall: Project Summary The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center is an academic-public partnership between an inte...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center
ADMINISTRATIVE CORE: PROJECT SUMMARY The Administrative Core for the Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center will prov...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (ACCERT) Center
RESEARCH METHODS, MEASURES, AND DATA MANAGEMENT (RMMDM) CORE: PROJECT SUMMARY Evaluations of interventions that target the numerous social drivers of health (SDOH) factors experien...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (ACCERT) Center
SOCIAL DRIVERS OF HEALTH (SDOH) RESEARCH PROJECT: PROJECT SUMMARY In the US, individuals and families living in poverty are placed at increased risk for cancer. Living in an under-...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center
COMMUNITY RESPONSIVE RESEARCH PROJECTS: PROJECT SUMMARY The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center will support four...
A Phase II Controlled Trial of Allogeneic Mesenchymal Stromal Cells for the Treatment of Refractory Lupus (MiSLE)
Abstract Cellular therapies for the treatment of autoimmune diseases offers a novel treatment option with possible increased efficacy and decreased toxicity. We are performing the...
The TMS-evoked potential as a measure of cortical excitation and inhibition during cognitive processes
ABSTRACT Non-invasive recordings of human brain activity – be it of BOLD or neural field potentials – all share a common, insurmountable weakness: it is impossible to identify whet...
Understanding the role of the nuclear pore complex in undifferentiated cell proliferation and gene gating
PROJECT SUMMARY / ABSTRACT The nuclear envelope (NE), a double-membrane structure surrounding the cell nucleus, and the nuclear pore complex (NPC), the largest protein assembly res...
Modeling the role of age at traumatic brain injury in the development of Alzheimer's Disease and related dementias
Project Summary Growing clinical evidence suggests that traumatic brain injury (TBI) is a major risk-factor over an individual’s lifetime, and results in symptoms and pathophysiolo...