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99,167 grants found
Showing 3,901 – 3,920 of 99,167 grants
A New Therapy for Neurodevelopmental Mitochondrial Disorders
Project Summary Eight out of ten children with mitochondrial disorders die before three years of age. The most critical predicting factor of such a fatal outcome is the age of dise...
X-ray Visualized Immunosensor (X-VIS)
Program Director/Principal Investigator (Last, First, Middle): Anker, Jeffrey N. Abstract Our goal is to fabricate and validate a novel immunosensor which attaches to implanted med...
Computational de novo design of macrocyclic type I Signal Peptidase inhibitors
The emergence of antibiotic resistance poses a global medical threat. The discovery of new antibiotics from naturally-occurring secondary metabolites or from high-throughput screen...
Addressing Physical Activity Among Adults with Vision Impairment
PROJECT SUMMARY People with vision impairments or blindness routinely face substantial challenges in everyday living that can significantly limit their participation in physical ac...
CA1 cell-type susceptibility in Alzheimer's
Abstract Advanced neuroimaging techniques have shown the impacts of Alzheimer’s disease (AD) pathology propagation and their structural repercussions in the brain. Recent studies s...
Tracking Autocorrection to Explain its Sensitivity to AD
Alzheimer’s disease (AD) is known to cause subtle changes in language production years before diagnosis, yet current behavioral tests take limited advantage of linguistic tools to...
Contributions of Brain Trauma to AD/ADRD Neuropathology, including CTE, and Resulting Clinical Outcomes
Traumatic brain injury (TBI) accounts for ~2.5 million emergency visits in the US each year and is a major public health concern. Individuals who experience TBI are at increased ri...
Building a Cancer Epidemiology Cohort to Investigate Factors Associated with Higher Risk of Colorectal Cancer among Alaska Native People
PROJECT SUMMARY/ABSTRACT Alaska Native (AN) people have the highest recorded rate of colorectal cancer (CRC) in the world with twofold higher incidence and mortality than US whites...
Care Integration, Supportive Housing, and Outcomes for Medicaid Accountable Care Organization Enrollees with Behavioral Health Conditions
PROJECT SUMMARY Close to 65 million US adults have a behavioral health condition (BHC), including mental health and substance use disorders.2 Persons with BHCs have a greater burde...
Substance Misuse and Family Violence Treatment for Fathers
PROJECT SUMMARY / ABSTRACT The proposed stage II intervention efficacy trail is designed to address two significant co-occurring issues for fathers with substance use (SU) problems...
Structural surfaceomics to probe conformation-selective immunotherapy targets
PROJECT SUMMARY/ABSTRACT The Problem: Cellular immunotherapies targeting surface proteins are one the most exciting new modalities in cancer. However, most tumors lack surface targ...
Digitally Prompted Parenting: A Text Message Parent-Based Alcohol Intervention for Incoming College Students
Project Summary Drinking remains a significant public health concern on college campuses with the transition into and first months of college identified by NIAAA as a critical high...
Integrative multivariate association and genomic analyses
ABSTRACT Recently, as part of the enhancing Genotype Tissue-Expression (eGTEx) project, methylome data on subsets of GTEx samples (N=987) from nine tissue types of 424 subjects hav...
TARGETING MASH WITH NOVEL SMALL MOLECULE TXNIP INHIBITOR
Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) (aka NAFLD and NASH) affects 1 billion people, yet no approved therapy is available. Int...
SIV zoonosis using humanized mice
Project Summary/Abstract: The main goal of our proposed studies is to evaluate select SIVs for their potential for human transmission using a humanized mouse (hu-mouse) human surro...
Microphysiological platform for analyzing multiple myeloma's tumor microenvironment, enabling immunotherapy assessment and drug screening.
ABSTRACT The tumor microenvironment (TME) plays a critical role in hematologic malignancies, especially in multiple myeloma (MM). Each cellular and non-cellular component of the TM...
Nano-CRISPR extracellular vesicle sensing system for longitudinal tumor monitoring
Detection of reliable biomarkers that represent treatment response and drug resistance remains a major clinical challenge for ovarian cancer. Extracellular vesicles (EVs) represent...
Spatial protein-protein interaction networks in situ by multiplexed proximity ligation
Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) gene mutations have been successfully treated with EGFR tyrosine kinase inhibitors (EG...
The Public Mucosal Antibody Repertoire in HIV-1 Infection
PROJECT SUMMARY Restoring the integrity of the gastrointestinal tract could be key to counteracting the spectrum of inflammation- associated debilitating illnesses and increased mo...
A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis
Project Summary Tumors reside within a complex multicellular ecosystem comprised of malignant and non- malignant cells, where interacting cells and molecules are organized in space...