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99,167 grants found
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State-dependent modulation of olfactory behavior
Project Summary Hunger and thirst are powerful motivational states that drive intense attraction to need-related stimuli. Here, we investigate how hunger and thirst differentially...
Integrative analysis of electrical and mechanical dyssynchrony to improve cardiac resynchronization therapy
PROJECT SUMMARY Cardiac resynchronization therapy (CRT) is a standard treatment for heart failure (HF) by coordinating the function of the left and right ventricles. However, 30-40...
Mitochondrial-targeting Exosomes for Neuroinflammation
Project Summary: Neuroinflammation is a condition that can cause damage to the brain and lead to diseases like Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis...
Temperature-sensitive germline structures and temperature thresholds of fertility in Caenorhabditis nematodes
PROJECT SUMMARY Species from worms to humans show a critical loss of fertility when exposed to elevated temperatures. This conserved response to temperature stress affects both mal...
Scalable fabrication of high-density amorphous silicon carbide microelectrode arrays for chronic neural interfacing
PROJECT SUMMARYIntracortical microelectrode arrays have long been used to record neural activity in basic science and clinical research studies of the brain. To date, carbon fiber...
Imaging of Mitochondial Complex I function in Down Syndrome
Abstract This new R21 application is submitted in response to RFA-OD-21-007 (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE). The...
A hybrid effectiveness/ implementation trial using online tools to increase weight loss among primary care patients
PROJECT SUMMARY/ABSTRACT The goal of the proposed project is to test the effectiveness of a primary care-situated intervention focused on motivating and guiding patients to use emp...
Using MRI to Facilitate Precision Medicine for Infants with Cleft Palate
PROJECT SUMMARY Orofacial clefting is the most common birth defect in the United States and the leading cause of velopharyngeal insufficiency, the inability to close the velopharyn...
Light pipe microscope for ultra-large-scale cellular-resolution whole-neocortex two-photon calcium imaging of mammalian brains
Project Summary/Abstract:To understand the function and dynamics of neural circuits that control behaviors and cognitions, we need to observe the neuronal network at a cellular res...
Enhancing treatments for myeloid leukemia associated with Down syndrome
PROJECT SUMMARY Myeloid Leukemia associated with Down syndrome (ML-DS) patients have high 5-year overall survival (OS) rates when treated exclusively with cytarabine (AraC)-based p...
Uremic Toxins and Cardiovascular Disease
Chronic Kidney Disease (CKD) affects 15% of individuals in the U.S. and is an independent risk factor for cardiovascular disease (CVD) in multiple meta-analyses and cohort studies....
Integrative modelling of single-cell data to elucidate the genetic architecture of complex disease
PROJECT SUMMARY/ABSTRACT Leveraging Genome Wide Association Studies (GWAS) to understand disease has proven challenging, as the underlying biological mechanisms are often poorly ca...
A biopsychosocial approach to the deep phenotyping of communicative participation in adolescents with Down syndrome
Over half of adolescents with Down syndrome (DS) have difficulty being understood by others which negatively impacts their engagement in daily life activities that require communic...
Clinical progression and predictors of outcomes in congenital Zika syndrome
PROJECT SUMMARY/ABSTRACT Although rates of congenital Zika virus syndrome (CZS) have declined since the 2015–2016 Zika virus (ZIKV) outbreak in Brazil, transmission of the virus st...
Trans-synaptic control of GPCR signaling in opioid reward
PROJECT SUMMARY Opioids exert their addictive effects by altering signal processing in the reward circuit of the basal ganglia. This action involves multiple adaptations, including...
The impact of structural racism during pregnancy on future cardiopulmonary health
Project Summary Cardiovascular disease (CVD) is the leading cause of death in women in the United States, with profound racial-ethnic disparities present. Mounting evidence suggest...
Cardiovascular and neuromuscular issues in chronic pain
PROJECT SUMMARY / ABSTRACT Although chronic pain (CP) affects over 20% of the U.S. population, little is known about associated physiological consequences, which likely contribute...
Wireless MRI with a stand-alone, platform-independent wireless integrated radio-frequency/shim coil array and cloud-based data processing workflow
PROJECT SUMMARY / ABSTRACT Technical advances in magnetic resonance imaging (MRI) have led to a wide range of imaging techniques, contrast mechanisms, and clinical applications. Ho...
Telehealth Exercise and Mindfulness of Pain in knee Osteoarthritis (TEMPO): A digital Feasibility Study
PROJECT SUMMARY/ABSTRACT Exercise is recommended as the first-line intervention for managing chronic pain in people with knee osteoarthritis (OA). However, activity and exercise re...
The U.S. Deprescribing Research Network
MODIFIED PROJECT SUMMARY/ABSTRACT SECTIONDeprescribing is an essential component of safe and effective health care for older adults, with particular relevance to older adults with...