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99,167 grants found
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Endothelial cell-assisted extracellular vesicle bioengineering for cytoplasmic delivery of therapeutic molecules
Project Summary Current paradigms of drug development have made remarkable progress in treating and preventing disease by effecting the function of a single target enzyme, or recep...
Enhancing and Archiving Genomic Data of the PSID Child Development Supplement
Project Summary The Panel Study of Income Dynamics (PSID) is a longitudinal survey of a nationally representative sample of U.S. families that began in 1968. Together with the PSID...
BRAIN CONNECTS: Photoemission Electron Microscopy for Connectomics
We propose to develop a new microscope for connectomes with the potential to reduce the price of a connectomic voxel by order(s) of magnitude. We will focus on a relatively unexplo...
Targeting Minority Stressors to Improve Eating Disorder Symptoms in Sexual Minority Individuals with Eating Disorders
PROJECT SUMMARY/ABSTRACT Eating disorders are one of the deadliest psychiatric disorders and are associated with high economic burden and numerous physical health consequences. One...
CXCL9/10 Macrophage Induced CXCR3+ T-cell Recruitment to the Heart Contributes to Immunotherapy Myocarditis
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used as novel cancer therapeutics to release intrinsic brakes on T-cell cytotoxicity against...
Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile Technology
PROJECT SUMMARY Adults with Down syndrome (DS) are twice as likely to be obese (BMI > 30kg/m2) than their peers without DS. The health consequences of excessive adiposity includ...
Extended release buprenorphine as a novel low-dose induction strategy
Project Summary Buprenorphine reduces overdose mortality by up to 70%, making it one of the most critical interventions to combat the opioid overdose crisis. With the increasing pr...
Support in adolescents' cross-gender friendships: Understanding girls' disadvantage
Project Summary During adolescence, friends meet more of youths’ relationship needs, including needs for support. Importantly, despite hundreds of studies focused on same-gender fr...
Discovery and validation of multi-omic plasma biomarkers for Adrenomyeloneuropathy
PROJECT SUMMARY/ABSTRACT The goal of this project is to utilize omics approaches in conjunction with machine learning tools to develop novel prognostic and monitoring biomarkers fo...
Investigating spatial and temporal heterogeneity in mitochondria during aging using in vivo high-content chemical imaging
PROJECT SUMMARY Title: Investigating spatial and temporal heterogeneity in mitochondria during aging using in vivo high- content chemical imaging The spatial and temporal regulatio...
Unraveling the interplay between the transcriptional co-regulator Cited2 and maternal folic acid in the regulation of neocortical development
PROJECT SUMMARY / ABSTRACT Disruptions in neuronal development and connectivity within the neocortex, the area of the brain responsible for high cognitive function, are found in ma...
Microanalytical Peptide-Peptidase Profiling of the Brain Renin-Angiotensin System in a Genetically Diverse Alzheimer's Disease Mouse Model
Summary/Abstract High blood pressure is considered a risk factor for dementia and Alzheimer's disease (AD) progression. The renin-angiotensin system (RAS) is a hormonal and ne...
Cognitive performance following a natural disaster and demographic and socioeconomic outcomes
Abstract The transition to young adulthood involves navigating educational investments, job opportunities, entry into marital unions, and decisions about whether and when to have c...
Photodynamic Therapy for Aortic Aneurysms
Project Summary Abdominal aortic aneurysms (AAA) are a leading cause of death worldwide, and no medical treatment is currently available. It is now accepted that aneurysm growth is...
Single cell analytics and drug discovery at the endometrial-myometrial junction in symptomatic adenomyosis
Adenomyosis is a common, understudied, estrogen-dependent uterine disorder that greatly impacts the well- being of women. It is characterized by endometrial cells in the myometrium...
Integrating single-cell omics and ancestry-adjusted eQTL mapping to characterize Tuberculosis immune response
Tuberculosis (TB) remains the leading infectious cause of death worldwide. A quarter of the human population is exposed to TB of which 5-15% will progress to active disease. Despit...
DNA Recorder: Living biosensor for arbitrary DNA
Project Summary Recent decades have revealed the profound impacts that gut microbiota have on human health. Far beyond being simply pathogenic vs benign, gut microbes impact a vari...
Engaging reticulospinal inputs to improve walking
Abstract Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatorydeficits severely impact daily functions resulting in lower q...
Contribution of insertion sequence mediated tandem chromosomal amplification to bacterial heterogeneity
The long-term goal of the application is to understand how insertion sequences (IS) in bacterial genomes create heterogeneous subpopulations by amplifying chromosomal segments. IS...
Investigating the role of lipid metabolism in the biogenesis of lysosome-related organelles
Project Summary: Investigating the role of lipid metabolism in the biogenesis of lysosome-related organelles Lysosome-related organelles (LROs) are cell type-specific compartments...