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99,167 grants found
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Assessment of consumer response to smokeless tobacco modified risk marketing orders
ABSTRACT Some non-combustible tobacco products, such as various forms of smokeless tobacco (ST), can pose significantly fewer risks to individual users than traditional cigarettes,...
Efficacy of the Improving Participation after Stroke Self-Management-Rehabilitation (IPASS-R) program in sub-acute stroke
Project Summary/Abstract The long-term goal of this research is to improve self-efficacy, activity performance, and health in individuals with stroke. Current stroke rehabilitation...
Targeting WNT7A Signaling in Pulmonary Fibrosis
Project Summary Idiopathic pulmonary fibrosis (IPF) is a fatal form of progressive lung fibrosis (scarring), resulting in a loss of 40,000 Americans a year - a number of deaths sim...
Leveraging Data for Infants with Cleft to Grow and Flourish: The BLOOM Study
ABSTRACTInfants with orofacial clefts (‘cleft’) are at high risk of malnutrition. Over 5,000 infants are born with a cleft in the United States each year. By 3 months of age an est...
Advancing Water Security: A Community Participatory School-Based Hydration Intervention
PROJECT SUMMARY Drinking water instead of sugar-sweetened beverage (SSBs) can help prevent obesity and dental caries, two of the most prevalent pediatric diseases, disproportionate...
The genomics and consequences of gut bacterial adaptation to high-fat diets
Title: The genomics and consequences of gut bacterial adaptation to high-fat diets Project Summary: The gut microbial communities of humans and other mammals respond rapidly to cha...
Designing a deployable and adaptable plasmonic sensing platform for infectious disease surveillance
SUMMARY This proposal aims to address the critical need for cost-effective, sensitive, and accurate point-of-need (PON) testing for infectious diseases by developing an adaptable a...
Direct Targeting of MYC in Cancer with Hyperstable Synthetic Transcriptional Repressors
PROJECT SUMMARY Transcription factors (TFs) are master regulators of gene expression and have been implicated in many disease states, including in cancer. Of these, the basic helix...
Epigenetic Pathways of Socioeconomic Disparities in Physical and Cognitive Health Across the Lifespan
Project Summary Children who grow up in low-income homes are at risk for worse physical and cognitive health for their entire lives, a phenomenon known as the “long arm of childhoo...
Oxytocin Neurotransmission Overcomes Sleep Apnea-Related OIRD Hypersensitivity
This proposal seeks to uncover the biological basis for why sleep apnea patients are more sensitive to opioid- induced respiratory depression (OIRD) - the primary cause of death du...
Dysregulation of calcium signaling in the initiation of fatty liver disease
ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is linked to insulin resistance, type 2 diabetes mellitus (T2DM) and several other major comorbidities. Hepatic carbohydrate and...
IL-10 Delivery Using Extracellular Vesicles to Delay Preterm Birth
PROJECT ABSTRACT Recently released “Born Too Soon” by WHO and many other global organizations (May 2023) reported 152 million preterm births (PTB) worldwide in the past decade, wit...
Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers
Project Summary. Greater than 20% of the active US workforce are shift workers who, because of their work schedules, have disrupted eating patterns, sleep/wake cycles, and light ex...
Floss: a novel method for oral mucosal vaccination
Floss: a novel method for oral mucosal vaccination The overall goal of this proposal is to develop a novel method of oral cavity mucosal vaccination. The mucosal surfaces serve as...
Discovery and optimization of ApoE4 correctors for the treatment of Alzheimer's Disease
PROJECT SUMMARY Alzheimer's disease (AD) is a major public health crisis with no effective treatments. Apolipoprotein E (ApoE) has three major polymorphic alleles, denoted Apo...
Equity-Focused Implementation of LGBTQ-Affirmative Cognitive Behavioral Therapy: A Hybrid Implementation-Effectiveness Trial
Background: Lesbian, gay, bisexual, transgender, non-binary, queer/questioning, and other sexual/gender minority (LGBTQ+) Veterans have disproportionate risk for poor mental health...
Reducing Evictions, Homelessness, and Poor Health Outcomes Among Washington State Veterans: Integrating Novel State Data into Analytic and Predictive Models of Housing Insecurity
Background: There is a paucity of reliable, household-level data on evictions. We have no data on how many Veterans are evicted each year, whether they regain housing or not after...
Implementing a Decision Support Tool to prevent Community-Acquired Pressure injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic.
Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life. Persons with SCI are at...
DART.3-Revolutionizing Neuropsychiatric Treatment through Noninvasive, Programmable Cell-Type-Specific Neuropharmacology
DART.3―Revolutionizing Neuropsychiatric Treatment through Noninvasive, Programmable Cell-Type-Specific Neuropharmacology ABSTRACT Neuropharmacology is central to the treatment of b...
Endothelial Proline Utilization in Pulmonary Arterial Hypertension
PROJECT SUMMARY/ABSTRACT Pulmonary arterial hypertension (PAH) is characterized by inflammation, endothelial dysfunction, and metabolic dysregulation, which promote fibroproliferat...