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99,167 grants found
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Selective Glucocorticoid Receptor Antagonism in Alcohol Use Disorder: A Human Neuroscience Study
ABSTRACT/SUMMARY Perturbations of the hypothalamic-pituitary-adrenal (HPA) axis characterize alcohol use disorder (AUD). The HPA axis is the primary stress-response system and cort...
Single Cell Transcriptomic Profiling of Multiple System Atrophy Brain
Project Summary/Abstract Multiple system atrophy (MSA) is a rare progressive neurodegenerative disease characterized by selective accumulation of α-synuclein in glial cytoplasmic i...
Chronic and acute molecular programs enabling working memory
Abstract Working memory is a form of short-term memory that is required for most daily activities, from reading, to driving, to conversing. As such, deficits in working memory are...
Neural Mechanisms Underlying Linguistic Context Use for Speech Processing in Aging
Project Summary/Abstract A frequent complaint in older adults is difficulty with speech comprehension, especially in the presence of background noise, such as when at a busy restau...
Long-term reliable neuroprosthetic control of a robotic arm and hand using electrocorticography.
PROJECT SUMMARY Multiple neurological diseases [e.g. spinal cord injury (SCI), amyotrophic lateral sclerosis (ALS), brain stem stroke] can all result in severe and devastating limb...
Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia
PROJECT SUMMARY Insomnia is prevalent among middle and older age adults, with detrimental effects on daytime function as well as adverse health outcomes, including increased risk f...
A Selective Serotonin Reuptake Inhibitor for Asthma Patients with Frequent Exacerbations
Project Summary/Abstract Asthma prevalence has increased in recent years with 8.4% of adults diagnosed with asthma. Asthma can be a lifelong disease. These rates increase with age,...
Identifying facilitators of coordinated care for survivors of intimate partner violence: Formative research towards intervention development
PROJECT SUMMARY Coordinated care, the process of identifying at-risk individuals and connecting them with health and social services at the point of care, is an important evidence-...
E7 TCR-T cell therapy for HPV-associated cancers
PROJECT SUMMARY HPV-associated malignancies include cancers of the cervix, oropharynx, anus, vulva, vagina, and penis. They cause thousands of deaths in the United States each year...
Functional efficacy of cannabidiol in modulating the adverse effects of heroin in primates.
PROJECT SUMMARY The recent marked increase in misuse and abuse of opioids and the epidemic of opioid overdose mortality have greatly affected our society and global community. Give...
Patient activation, cognition, and self-management for LVADs
PROJECT SUMMARY Patient activation, cognition, and self-management for LVADs We propose to study patient activation (PA) for patients with left-ventricular assist devices (LVADs)....
Disruption of Endosomal Microautophagy by Pathological Tau Protein
PROJECT SUMMARY/ABSTRACT One of the pathological features of Alzheimer’s disease (AD) is the dysfunction of protein degradation pathways including macro- and chaperone mediated aut...
Multimodal Interventions to Prevent Anal Sphincter Dysfunction After Childbirth-Related Neuromuscular Injury
ABSTRACT Fecal incontinence (accidental leakage of stools; FI) is a major medical illness, occurs in a significant population of women (>7%) and is under reported. Most common c...
Curved Implantation of Flexible Microelectrode Arrays for High-Density Mapping of Nonlinear Brain Structures and Circuits
Project Summary The brain is nature’s most sophisticated signal-processing system. Unlike human-made integrated circuits, the brain circuits organize in a complex three-dimensional...
Understanding the regulation of mtDNA heteroplasmy and integrity
PROJECT SUMMARY Mitochondria have retained a small circular genome (mtDNA) that encodes essential components of the elec- tron transport chain. Mutations in the mtDNA can cause dev...
Role of Monocyte Delta Like-4 (Dll4) in HIV-Associated Cerebral Small Vessel Disease
The goal of the current proposal is to determine the role of monocyte Delta like-4 (Dll4) in cerebral small vessel disease (CSVD) and its impact on cognition in people with HIV (PW...
Single-cell mitochondrial mutation lineage tracing of non-dysplastic and dysplastic Barrett's esophagus
Project Summary The incidence of esophageal adenocarcinoma and its premalignant metaplastic precursor Barrett's esophagus (BE) have both displayed marked increases in incidenc...
Characterization of senescent cell populations in skeletal aging
There is now extensive evidence that cellular senescence drives age-related bone loss and multiple other aging co-morbidities. Characteristics of senescent cells include increased...
Mechanisms of Enzyme Regulation by Viperin in the Cellular Antiviral Response
Project Summary Eukaryotic cells have developed sophisticated defenses aimed at limiting viral replication and thereby preventing infection from escalating to other cells. This R35...
Investigation of RNA interference and related gene regulatory mechanisms
PROJECT SUMMARY Over evolutionary time, species access innovations that evolve in parallel lineages. The mitochondrion and chloroplast genome-transfers provide stunning examples. T...