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99,167 grants found
Showing 361 – 380 of 99,167 grants
A human abuse potential study of kratom
PROJECT SUMMARY/ABSTRACT The escalating use of kratom, an herbal substance with opioid-like properties, has raised significant public health concerns due to its potential for abuse...
Addressing Food Insecurity in Transplant and Cellular Therapy Patients with Healthcare-Community Partnerships
ABSTRACT Food insecurity (FI), defined as a lack of consistent access to enough food for every person in a household to live an active, healthy life due to insufficient money or ot...
Brain CHEC-AC (Brain and Cognitive Health Equity Campaign for Allegheny County)
ABSTRACT Despite being at nearly twice the risk of developing Alzheimer’s or a related dementia (ADRD), Americans identifying as Black or African American are 35% less likely to be...
ACVR1 sensory neuron-specific signaling in neuropathic pain and injury-induced heterotopic ossification
PROJECT SUMMARY Debilitating pain, a hallmark of tissue injury and neuropathy, is an unmet clinical challenge particularly in musculoskeletal diseases, such as heterotopic ossifica...
Maintenance of Human and Animal Food Rapid Response Team - Wisconsin
Project Abstract The efforts undertaken as part of this Cooperative Agreement will further increase the capacity of Wisconsin’s food safety regulatory programs to protect public he...
New Treatment Strategies and Epigenetic Biomarker for Management of BPH
PROJECT SUMMARY: Over 90% of adult males develop lower urinary tract symptoms (LUTS) secondary to bladder outlet obstruction by age 80 secondary to benign prostatic hyperplasia (BP...
Novel Strategies for Understanding and Treating Fibrous Dysplasia
PROJECT SUMMARY The overall goals of this diversity supplement are to develop the candidate’s background in biological and translational sciences and position her to be a strong ca...
Exploring nano-bio interactions for cell-specific targeting of osteoarthritis
Exploring nano-bio interactions for cell-specific targeting in osteoarthritis In the US, osteoarthritis (OA) is the most prevalent chronic joint disease. However, there is still no...
ADEPT: Assessing Diversity Effects Post Affirmative Action Restrictions in Medical Schools
ABSTRACT The affirmative action restrictions issued by the Supreme Court of the United States (SCOTUS) on June 29, 2023, significantly limit the use of race-conscious admissions in...
Ano4 and Metabolic Health
PROJECT SUMMARY Obesity is a major risk factor for many chronic medical conditions, including diabetes, cardiovascular disease, depression, and cancer. Elucidating the neural mecha...
Alpha- to Beta-Cell Communication in Health and Disease
Summary of Work Glucagon is canonically viewed as an essential counterregulatory hormone that prevents hypoglycemia by driving endogenous glucose production (EGP) in the liver. We...
The Black Zones: Harnessing Mobile Tech Enabled Community Driven Data, Big Population, Health Data, & Agent-Based Models to Transform the Measures & Metrics around Structural Racism & Black Longevity
Abstract Racial residential segregation (RRS) is a form of structural racism and a key driver of the life expectancy gap for African Americans (AAs) and Black Immigrants (BI) in th...
Night- to-Night Variability in Sleep Disordered Breathing: Sex and Gender-Related Predictors and Impact on Obstructive Sleep Apnea Clinical Heterogeneity
PROJECT SUMMARY/ABSTRACT The current standard measure of OSA, the apnea-hypopnea index (AHI) underestimates women’s OSA severity compared to men, which may lead to missed diagnoses...
Development of three KSHV vaccine platforms and chimeric MHV68-K-G for in vivo mouse infection study
Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is a prevalent virus that establishes a lifelong persistent infection in humans and is associated with Kaposi's sa...
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathology
Cognitive decline in the aging brain is driven by overlapping neurodegenerative and cerebrovascular pathologies.Over 80% of Alzheimer's disease (AD) patients co-present with c...
A novel live biologic for the prevention and treatment of NEC-induced neurodevelopmental impairment
SUMMARY: Worldwide, up to 25% of premature infants born prior to 31 weeks gestation, and up to 50% of those born prior to 28 weeks gestation, have neurodevelopmental impairment (NI...
Neural Mechanisms of Colored Light Driven Analgeisa
Chronic musculoskeletal pain (cMSP), including fibromyalgia, affects over 14% of the population, is a leading cause of disability worldwide, and is often refractory to available tr...
Differential Impacts of Person and System Level Determinants of Health on Dyadic Heart Failure Management: The IMPACT-D Study
Heart failure (HF) is the fastest-growing cardiovascular disorder and a leading cause of urgent healthcare utilization in the U.S. Effective HF physical self-care (i.e. behaviors t...
Energetic metabolism in RASopathies as a novel therapeutic target
ABSTRACT RASopathies encompass a spectrum of genetic disorders caused by germline gain-of-function variants in genes encoding critical components of the RAS/MAPK pathway, leading t...
Regulation of connective tissue in the cell renewal of mature taste buds
Project Summary/Abstract Mammalian taste buds are a cluster of specialized epithelial cells residing primarily in the epithelium of the lingual taste papilla which covers a core of...