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99,167 grants found
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Core A - Administration core
Summary: In order to answer fundamental questions regarding the factors that govern ABO(H) immunity and incompatibility, new tools and approaches will need to be leveraged in a hig...
Core B - Microbial glycan microarray core
SUMMARY: Naturally occurring anti-ABO(H) antibodies represent the most common barrier to transfusion and transplantation. These antibodies can vary wildly in titer and specificity,...
Project 1 - Examining the impact of microbial dynamics on B cells responsible for anti-blood group antibody formation
SUMMARY: Despite being the first human polymorphisms described, ABO(H) blood group antigens and corresponding anti-ABO(H) antibodies continue to be the most common immunological ba...
Project 2 - Convergence of innate immunity and microbial communities in the regulation of anti-blood group antibody development
Project 2 SUMMARY: Anti-ABO(H) antibodies, which form spontaneously within the first few months of life, represent the most common immunological barrier to transfusion and transpla...
Behavioral quantification through active learning and multidimensional physiological monitoring
Project Summary/Abstract Naturalistic contexts provide the opportunity to study the brain and behavior in response to the ethological problems an animal is evolutionarily designed...
A modeling framework and arena for measuring contextual influences of behavior
PROJECT SUMMARY Social behaviors are essential for survival and reproduction. They also evolve quite rapidly and can vary even among closely related species. Traditionally, social...
Cohesinopathies and Ciliopathies - What's the Connection?
Summary Cilia are surface-exposed organelles found on most eukaryotic cells, needed to sense and transduce varied sensory stimuli. Not surprisingly, mutations in genes that disrupt...
Towards High-Resolution Neuro-Behavioral Quantification of Sheep in the Field to Study Complex Social Behaviors
Abstract Social animals, including humans, engage in complex collective behaviors in the field. While there are simple models of collective decision making and movement that are am...
Calorie Restriction, Mitochondrial DNA Heteroplasmy, Cardiometabolic Profiles, and Biological Aging
Project Summary Calorie restriction (CR) has the potential to attenuate aging; however, the mechanisms by which CR enhances longevity and reduces disease burden are not fully under...
Interrogation of T cell Bystander Activation in Scleroderma
PROJECT SUMMARY Fibrosis is a common final outcome of most human chronic inflammatory diseases and has been estimated to contribute to almost half of all deaths in the world1. It c...
Developmental sleep disruption interacts with underlying CHD8 genetic vulnerability in autism spectrum disorder
PROJECT SUMMARY Autism spectrum disorder (ASD) is a common neurodevelopmental condition that affects social behavior and cognitive flexibility. Sleep disruption is a common comorbi...
In vivo mechanisms of Dorsal-mediated transcriptional control in development
Project Summary/Abstract The correct implementation of developmental programs depends on information encoded in an organism’s DNA. Despite decades of work in dissecting the spatial...
Endothelial Signaling in Exercise Metabolism
PROJECT SUMMARY Exercise is a powerful strategy to improve skeletal muscle metabolism that can both prevent and reverse disease. However, the complex signaling that drives the imme...
Investigating the mechanism of action of antibacterial synthetic unsaturated fatty acids in methicillin-resistant Staphylococcus aureus
PROJECT SUMMARY Methicillin-resistant Staphylococcus aureus (MRSA) continues to gain resistance to existing antibiotics, and the lack of big pharma pipelines to develop new compoun...
The therapeutic effect of cannabigerol (CBG) with or without cannabidiol (CBD) in diet-induced non-alcoholic fatty liver disease
Research Summary/Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease that can progress into a more advanced form- non-alcoholic...
Improving Strength Training in Older Adults
PROJECT SUMMARY/ABSTRACT Maintaining muscle mass and strength in older adults is critical for preventing mobility disability, falls, and long-term independence. Although ‘high inte...
Novel tunable metformin-releasing injectable scaffolds to enhance dental pulp stem cell-based craniofacial bone regeneration
PROJECT SUMMARYThe long-term goal of this proposal is to develop novel tunable metformin (Met)-releasing injectable scaffolds to sustain its local delivery and enhance regeneration...
Central & Peripheral Mechanisms of Respiratory & Autonomic Control Dysfunction in a Novel Model of SIDS: Predictive Biomarkers and the Role of the Extracellular Matrix
Project Summary The Triple Risk Model describes SIDS occurrences when an intrinsically vulnerable infant experiences an exogenous insult resulting in a chronically hypoxic/hypercap...
Dose Linear Energy Transfer Volume Histogram and Dosimetric Seed Spot Analysis in Spot Scanning Proton Therapy
PROJECT SUMMARY/ABSTRACT Radiation therapy may induce severe adverse events (AEs), and result in significant detriment to patients’ quality of life, especially in head and neck, su...
Defining the Role of HPV Integration Structures in HNSCC Molecular Heterogeneity
Abstract: HPV positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) comprises a progressively rising epidemic that will be a public health problem for several decades both be...