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The Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on Surfaces
Nearly two-thirds of all hospital-related infections are associated with biofilms, and Staphylococcus epidermidis biofilms are responsible for 40% of infections in hip and knee rep...
Dissecting divergent hematopoietic stem and progenitor cell ontogeny
Dissecting divergent hematopoietic stem and progenitor cell ontogeny during development Project Abstract 1 The hematopoietic and immune landscape is complex. The diversity is gener...
Nitric oxide inhibits Iron(II)2-Oxogluterate dependent demethylases to regulate DNA and mRNA methylation
ABSTRACT- Nitric oxide (NO) is an essential signaling molecule that mediates dichotomous effects along a pathophysiological concentration gradient. Low levels maintain physiologica...
Age, sex, hormonal status, and anti-inflammatory therapy for atherosclerosis
PROJECT SUMMARY. A great accomplishment of modern medicine is the increased lifespan of the population worldwide. Unfortunately, longevity also increased the healthcare burden due...
Early cannabis use and later opioid use disorder - the role of adverse childhood experiences, genetic liability and comorbid stimulant use
Abstract Opioid use disorder (OUD) is rare (2%) but associated with extraordinarily high morbidity and mortality. Opioids are the primary contributors to the soaring numbers of U.S...
Leveraging Large-Scale Biobanks to Discover and Define Rare Variant Effects in Hypertrophic Cardiomyopathy
SUMMARY Hypertrophic cardiomyopathy (HCM) affects up to 1:200 individuals and is a common cause of sudden cardiac death. Guidelines recommend genetic testing in HCM probands to hel...
Development of anti-LPS therapeutic antibodies for the treatment of Pseudomonas aeruginosa infections
SUMMARY The goal of this proposal is to develop therapeutic antibodies for the treatment of multidrug resistant (MDR) P. aeruginosa infections, with an emphasis on sepsis. With the...
Upstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancer
PROJECT SUMMARY / ABSTRACT Prostate cancer (PCa) is a clinically and molecular heterogenous disease, with distinct subtypes. These subtypes are associated with characteristic genom...
Polarity dysregulation in Alzheimer’s disease
Project Summary The vast majority of Alzheimer’s disease (AD) is sporadic, with aging being the biggest risk factor. Yet age- related changes within neurons that can facilitate AD...
Innovative closed-loop functional electrical stimulation control system for augmenting post-stroke gait
PROJECT ABSTRACT Functional electrical stimulation (FES) is a common rehabilitation technology that incorporates electrical stimulation timed with a functional task to augment pare...
Selective Positive Allosteric Modulators of a4b2 Nicotinic Receptors
ABSTRACT Tobacco addiction remains a leading cause of disease and death worldwide, and an increasing number of never- smokers are being exposed to nicotine via e-cigarettes. Howeve...
Vestibular Hair Cells
Vestibular deficits are highly prevalent and cause debilitating symptoms. Degeneration and ototoxin- induced injury of vestibular hair cells (HCs) are underlying causes of some ves...
The unique and combined effects of prenatal and early childhood programming on child maltreatment: Examining mechanisms of change
PROJECT SUMMARY/ABSTRACT Child maltreatment occurs at alarmingly high rates and represents a serious threat to children’s healthy development, with negative ramifications lasting i...
The mental health of crisis migrant families: A longitudinal, mixed-methods study of Puerto Rican child-parent migrants in the post-Hurricane María years
Project Summary/Abstract: Over 130,000 Puerto Ricans have migrated to the US since Hurricane María in 2017. They comprise a growing population of individuals and families who migra...
Dissecting the role of B lineage cells in mediating response of resectable lung cancer to neoadjuvant immune-based therapy
PROJECT SUMMARY Neoadjuvant and perioperative chemoimmunotherapy are the standard of care for the treatment of patients with resectable non-small cell lung cancer (NSCLC). Unfortun...
Multiscale genomic decryption of regulatory DNA
Project Summary/Abstract: Regulatory DNA encodes signals that are recognized by transcriptional regulators to drive development- and stimulus-specific patterns of gene expression....
The Developmental Effects of Environmental Enrichment on the Minor Cannabinoid Drug Reward and Cannabinoid Receptor Levels
Project Summary/Abstract Understanding individual differences in the vulnerability to drug abuse is an important component to developing better prevention and treatment strategies....
A Role of Multilevel Healthcare Access Dimensions in Ovarian Cancer Disparities
ABSTRACT Ovarian cancer accounts for more deaths than any other cancer of the female reproductive system. In 2021, there were 21,410 new cases of OC and 13,770 deaths. Remarkable p...
Novel regulation of the CDK4/Cdh1/Pin1 signaling axis for targeted breast cancer therapies
Project Summary/Abstract: The anaphase-promoting complex/Cyclosome (APC/C) is a well-defined multi-subunit E3 ubiquitin ligase that regulates targeted cell cycle regulators for deg...
Reducing Veterans' Risk of Atherosclerotic Cardiovascular Disease Through Pharmacogenomics Informed Statin Prescribing
Background: Despite the proven efficacy and safety of statins, nearly 250,000 Veterans at high-risk for cardiovascular disease (CVD) seen annually in primary care are not taking th...