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99,167 grants found
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Unmasking p38 MAPK Functions in Lysosome Homeostasis during Development and Aging
Project Summary Compromised tissue integrity is a major cause of debility during aging. Emerging findings suggest critical functions of lysosomes promoting tissue integrity. Our un...
Early Life Adversities and the Risk of Uterine Fibroids
Project Summary (Abstract): The racial disparity in uterine leiomyomata (fibroids) is profound among Black/African American women (BW) – with an earlier age of onset by 10-15-years...
Home-Based Community Health Worker Support for Mental Health among People Living with HIV in South Africa: A Hybrid Effectiveness Implementation Trial
PROJECT SUMMARY. South Africa (SA) is home to the largest number globally of people with HIV (PWH). Mental health (MH) conditions, particularly depression and harmful alcohol use,...
Mood, cognitive, and metabolic consequences of chronic vaporized cannabis exposure in mouse models of menopause
PROJECT SUMMARY The legalization of recreational and medicinal cannabis in several states across the US has increased the need to better understand its effects on the body, brain,...
Wirelessly Actuated Ciliary Stent for Minimally Invasive Treatment of Cilia Dysfunction
Project Summary The objective of this proposal is to create a novel ciliary stent integrated with wirelessly actuated artificial cilia for treating cilia dysfunction in various dis...
Hyperspectral chemical imaging via sum-frequency generation microscopic holography
Project Summary: This proposal outlines a new investigator grant (NIBIB Trailblazer R21) for the PI to develop a new holographic platform that enables high-speed, noninvasive 3D ch...
The role of long noncoding RNAs in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Over the past 40-years, the standard therapy for acute myeloid leukemia (AML), a highly fatal blood cancer, remains a combination of chemo drugs such as cy...
Quantitative Cerebral Oxygen Metabolic Imaging of Acute Ischemic Stroke
The objective of this project is to develop an easily accessible MRI-based cerebral metabolic rate of oxygen consumption (CMRO2) mapping for evaluating ischemic lesion viability in...
A20 and Tumor Immune Responses
Abstract Immunosuppressive and homeostatic mechanisms prevent immune cells and tissues from eliminating solid tumors, limiting the efficacy of anti-tumor immunity. Precise dissecti...
Peer-led Dynamic Choice HIV Prevention for Women at Elevated HIV Risk in Uganda
PROJECT SUMMARY/ABSTRACT Despite remarkable progress in HIV testing and treatment, HIV incidence remains unacceptably high among women and girls in eastern and southern Africa. In...
Meeting South African adolescent girls and young women who experience intimate partner violence where they are: Developing an implementation strategy for linkage to PrEP options
PROJECT SUMMARY Intimate partner violence (IPV) is a serious public health concern affecting adolescent girls and young women (AGYW) in South Africa, with a cumulative incidence of...
Mechanisms of nonvesicular cholesterol transport
ABSTRACT Our long-term objective is to define cellular pathways that regulate cellular cholesterol flux and to elucidate their impact on metabolism and pathology. Most of the free...
Explainable and Ethical AI for Studying Alzheimer's Disease
Alzheimer's Disease (AD) is increasingly becoming an immense economic and social challenge. By 2050, it's projected that 13.8 million Americans will be living with AD, an...
Genetics-informed dissection of human brain cell-cell communication in Alzheimer's disease progression
Abstract AD is an age-related neurodegenerative disease and the leading cause of dementia in the United States. It is characterized by a progressive decline of memory and cognitive...
Identification of trans-regulatory elements controlling MAPT transcription
Project Summary/Abstract Tau, coded for by the gene MAPT, can aggregate in the brain and is associated with many neurodegenerative diseases. Evidence suggests that the level of exp...
Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa
PROJECT SUMMARY/ABSTRACT Identification of neural and behavioral processes that drive eating disorder (ED) symptomatology is critical for the development of more effective interven...
Pathobiology of autoimmune Meibomian gland dysfunction
Dry eye disease (DED) is a chronic condition affecting millions worldwide, with approximately 21 million patients affected in the US. Symptoms of DED vary from mild irritation to s...
Origins and dynamics of HIV gp120 specific B cell memory in HIV negative high-risk individuals
PROJECT SUMMARY Decades of global effort have yet to result in a robust and effective preventative vaccine for HIV, although it has yielded remarkable insights into the likely requ...
Inhibition of Radiation-Induced Salivary Gland Fibrosis by Targeting Copper Metabolism
ABSTRACT A first-line treatment for head and neck cancer is radiation therapy, but ionizing radiation can lead to chronic oral complications such as fibrosis of the salivary glands...
Cochlear resident tissue macrophages in normal cochlear development and the response to CMV infection
PROJECT SUMMARY / ABSTRACT Congenital cytomegalovirus (CMV) infection can lead to sensorineural hearing loss (SNHL) long after resolution of acute infection, implicating lasting al...