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99,167 grants found
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A Family-Based Macro-simulation Model on the Supply and Demand of Care for ADRD
Project Summary In 2022, more than 6 million individuals suffered from Alzheimer's disease and related dementia (ADRD) in the United States, and this figure is projected doubl...
Investigating obesity and adiposity-induced alterations to the human endometrium
Obesity is a highly prevalent chronic disease that poses a significant public health risk. Almost 42% of US adults are affected by obesity with women at higher risk for severe obes...
Cell type vulnerability to pathogenic tau accumulation in hippocampal CA1
Alzheimer’s disease (AD) and other neurodegenerative diseases will have a global impact on health outcomes for people in the coming decades. Without a cure or preventative treatmen...
Dyadic Sleep Intervention for Patients with GI Cancer and Their Caregivers
Project Summary/Abstract Sleep disturbance is common in patients with cancer: 33% to 59% of patients (as opposed to 15% to 20% in the general population) report sleep disturbance,...
A preclinical therapeutic platform to develop GABAA alpha5 receptor positive allosteric modulators to improve cognitive function in schizophrenia
A preclinical therapeutic platform to develop GABAA α5 receptor positive allosteric modulators to improve cognitive function in schizophrenia. Cognitive dysfunction in neuropsychia...
Health Care Access, Quality, and Outcomes among Individuals with Dementia in Dual Eligible Special Needs Plans
Addressing the long-term care needs of a growing number of older individuals with Alzheimer's disease and related dementias (AD/ADRD) is one of the most daunting challenges fa...
End Diagnostic Overshadowing: Addressing Ableism in the Healthcare Context
Through our End Diagnostic Overshadowing: Addressing manifestations of ableism in the healthcare context program we aim to identify and create understanding of mechanisms underlyin...
The role of microtubule network in a mouse model of Alzheimer’s disease
PROJECT SUMMARY Alterations of a microtubule-binding protein tau are one of hallmarks of Alzheimer’s disease (AD), with progressive memory loss being one of its major symptoms. Tau...
Impacts and mechanisms of child sexual abuse in women's impaired fecundity and pregnancy outcomes
One in four girls residing in the U.S. will be sexually abused before they turn 18. Child sexual abuse (CSA) victimization is associated with an increased risk for morbidity, inclu...
Epigenetic regulation of intestinal tuft cells
Intestinal epithelial cells reside at the direct interface between the microbiota and mammalian host, and are thus uniquely poised to sense microbial signals that calibrate intesti...
Digital Cognitive Assessment of Preclinical Alzheimer's Disease and Related Dementias
PROJECT SUMMARY/ABSTRACT Effective drug treatment for Alzheimer’s disease (AD) may well be on the horizon. While the amyloid-tau- neurodegeneration (A/T/N) signature is recommended...
ZFHX4 sets alveolar fibroblast differentiation potential of mesenchymal progenitors in the fetal lung
PROJECT SUMMARY Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm and lung hypoplasia in newborns. The diaphragm defect can be surgicall...
Survival analysis of teeth treated with SDF to arrest caries in adults
PROJECT SUMMARY / ABSTRACT Dental caries is a preventable disease, however, it still affects large numbers of people globally and in the US. The Global Burden of Disease 2017 study...
Understanding the effect of Hao-Fountain syndrome-causing mutations on neuronal development
ABSTRACT Hao-Fountain syndrome is a newly identified rare pediatric neurodevelopmental disorder caused by deletions and mutations of the USP7 gene. The molecular mechanisms and pat...
Heterochronic hepatocyte transplantation to rejuvenate the aged liver
Abstract: Heterochronic parabiosis and serum transfer models have given evidence for the rejuvenating properties of young blood in old mice and equally potent deleterious effects o...
Role of autocrine cholinergic signaling in maintaining memory T cell responses in oral squamous cell carcinoma
PROJECT SUMMARY Response to immunotherapy remains less than 20% for Oral Cavity Squamous Cell Carcinoma (OSCC). The poor response is in part due to dysfunctional cytotoxic T cell a...
Local Administration of Particle-Anchored Cytokines as a Safe and Effective Cancer Immunotherapy
PROJECT SUMMARY / ABSTRACT The primary objective of this proposal is to develop a localized cancer immunotherapy using particle-anchored cytokines with prolonged intratumoral reten...
HIV Complex Causal Modeling: Gut Microbiome, Drug Use, and Immune Responses
PROJECT SUMMARY/ABSTRACT Human immunodeficiency virus (HIV) acquisition often co-occurs with drug use disorders (DUD), particularly in the context of injected drug use. Individuals...
Trial of Meaning Centered Psychotherapy for Mexican Patients with Advanced Cancer
PROJECT SUMMARY Further, more than one-quarter of cancer patients in Mexico suffer from a depression disorder and about half have significant mood disorder symptoms. Also, research...
Mitochondrial Metabolism and Cancer
PROJECT SUMMARY/ABSTRACT Transformation of normal cells to cancer cells involves complex changes influenced by oncogenes, inactivation of tumor suppressors, and disrupted signaling...