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99,167 grants found
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Long-term safety and effectiveness of Dengvaxia in the Philippines
Abstract The four serotypes of dengue virus (DENV1–4) are the leading cause of mosquito-borne viral diseases in humans. Dengvaxia, the first licensed dengue vaccine, was recommende...
Advanced Mouse Models of DDX41-mutated Myelodysplastic Syndromes
Project Summary Myelodysplastic Syndromes (MDS) are blood disorders caused by defective hematopoietic stem cells (HSC) that clonally expand and fail to produce blood cells of suffi...
A dynamic synaptic sensor controlling hippocampal CA3 circuit function
Summary: Moment-to-moment changes in synaptic strength are a dynamic property of many synapses including in regions of the brain known to be important for episodic memories. In the...
PROMOTE and TEACH Equity
ABSTRACT Minoritized pregnant patients sometimes face impossible choices between earning necessary income and adherence to prenatal care; these issues were highlighted in our forma...
Robot-assisted catheter placement with novel shape-sensing stylet to facilitate adaptive image guided pelvic brachytherapy
Project Summary Gynecologic malignancies accounted for over 114,810 new cancer cases and approximately 35,640 deaths in 2023 in the United States. Brachytherapy has been used to tr...
Mechanisms of Impaired Inflammation Resolution in Cystic Fibrosis Lung Disease
Patients with cystic fibrosis (CF) suffer from chronic infections and lung inflammation leading to bronchiectasis and, ultimately, respiratory failure. Although recent advances, in...
A Pediatric Atlas of Upper Airway Shape
ABSTRACT Airway abnormalities in children, such as subglottic stenosis (SGS) and Robin sequence (PRS), may result in breathing difficulties, risk of recurrent infections, hypoxia,...
Emerging Strategies for Therapy of Metastatic Brain Cancer
PROJECT SUMMARY Brain cancer remains a devastating disease and in particular, brain metastases (BM) from breast cancer represent the leading cause of fatality for women. The major...
Impact of Integrated Pet Care on Glycemic Control and Diabetes Responsibility
Project Summary/Abstract There is a critical need to develop innovative strategies in early adolescents with type 1 diabetes mellitus (T1DM) that develop self-efficacy and facilita...
SMAD5 signaling in Polycystic Ovary Syndrome
PROJECT SUMMARY It is generally accepted that there is a link between a woman’s reproductive and overall health. Following menopause, women are at an increased risk for developing...
2/2 Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
PROJECT SUMMARY Premenstrual dysphoric disorder (PMDD) is a severe affective disorder impacting millions of women worldwide, thought to be due to impaired sensitivity to hormone fl...
Using the generalized risk-adjusted cost-effectiveness (GRACE) model to advance health equity in use of novel treatments for Alzheimer's Disease and Related Dementias
Project Abstract The newer disease-modifying drugs for Alzheimer’s Disease (AD) target Aβ42 proteins and p-tau production and accumulation and include antibodies directed at Aβ epi...
Targeting scaffolding proteins to disrupt radioresistance in glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is an aggressive brain cancer type that responds poorly to standard treatment and ultimately develops chemo- and radioresistance. This is due, in...
Improving crouch gait in children with CP through error augmentation
Children with cerebral palsy (CP) commonly exhibit pathologic gait patterns. Crouch gait, which is characterized by excessive stance phase knee flexion and may be accompanied by ot...
Overcoming Limitations of BETInhibition in NUT Carcinoma
Project Summary/Abstract. NUT-fusion oncoproteins, most commonly BRD4-NUT, drive NUT carcinoma (NC), an aggressive, poorly differentiated squamous cancer with a 6.5-month median su...
Protective role of B cells in hyperoxic lung injury
High concentrations of inspired oxygen are necessary during treatment of critically ill patients with impaired lung function, such as those with acute respiratory distress syndrome...
Maximizing the efficacy of MDM2 inhibitor therapy for MDM2-amplified glioblastoma
PROJECT DESCRIPTION/ABSTRACT MDM2 amplification occurs in 3.5% of all malignancies and in approximately 10% of several highly aggressive malignancies, including glioblastoma. MDM2...
Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse: An RCT of CBT for Insomnia in Adults who Smoke
Abstract Deficient sleep aggravates negative mood and reduces self-control and represents a primary withdrawal symptom and robust predictor of relapse in adults who smoke. We propo...
Regulation of entorhinal cortex layer II vulnerability by a cell-type specific miRNA
Project Summary Neurofibrillary tangle formation and neurodegeneration occur, during preclinical Alzheimer’s disease (AD), in remarkably restricted cell populations, in the layer I...
Identification of early transcriptional and pathological changes undergone by vulnerable brain regions during prodromal Alzheimer's disease
Project Summary Alzheimer’s Disease (AD) presents a striking example of the selective cell tropism common to most neurodegenerative diseases. Early clinical symptoms (such as memor...