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99,167 grants found
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Dual targeting chemokine receptors prevents chemotherapy-induced cardiotoxicity
Doxorubicin (DOX) is an effective chemotherapeutic drug to treat cancer. However, DOX-induced cardiotoxicity (DICT) has limited its use. Dexrazoxane is the only current FDA-approve...
Multi-site photostimulation devices using porosity-based semiconductor heterojunctions for cardiac resynchronization therapy
Project Summary In cardiovascular disease diagnosis, treatment, and monitoring, a plethora of deformable biointerface devices are utilized. These devices are adept at gauging physi...
Multivalent mRNA-based malaria vaccines
The heavy burden of Plasmodium falciparum and Plasmodium vivax malaria drove international efforts to coordinate and integrate tools and programs for mosquito vector control, rapid...
Natural variation underlying extraordinary lifespan
Project Summary Aging, particularly the rapid increase in disease prevalence with age, has emerged as one of the top health challenges in the world today. Life expectancy in the Un...
Early Developmental Risk for Adult Cardiovascular Disease: High risk Subgroups, Biomarkers, and Mechanisms
This project seeks to generate new insights – of clinical and public/health/relevance – regarding the early identification and prevention of adult coronary heart disease (CHD). It...
Cortical Demyelination and Repair in Early Multiple Sclerosis.
PROJECT SUMMARY/ABSTRACT Multiple Sclerosis (MS) is an immune-mediated, demyelinating disorder of the central nervous system (CNS) and a leading cause of disability in young adults...
A Portable, Low-Cost, Pont-of-care Microfluidic System for Rapid Pharmacogenomic Screening of Patients with Major Depressive Disorder
Project Summary/Abstract The current approaches to prescribing medication to patients with major depressive disorder (MDD) involve a‘trial and error’ approach to prescribing select...
Langerhans cells and lymphatic regulation in immunity
In systemic lupus erythematosus (SLE), skin pathophysiology is linked to autoimmunity. Patients are photosensitive, able to develop inflammatory skin lesions with even ambient ultr...
Deciphering Molecular Mechanisms of Post-Stroke Depression in Aged Mice
PROJECT SUMMARY Stroke is the leading cause of adult disability. Over the last 20-years, with the decline in stroke mortality due to improvements in acute care, there has been an i...
A novel nuclear role for smooth muscle alpha-actin
ABSTRACT Pathogenic variants in ACTA2, which encodes smooth muscle α-actin (SMA), are a major cause of heritable thoracic aortic disease, and missense variants affecting two specif...
Discovery of small molecules targeting Polycomb repressive complexes 1 and 2
Discovery of small molecules targeting Polycomb Repressive Complex 1 ABSTRACT: The discovery that mutations and dysregulation of chromatin modifiers are major cancer drivers has in...
Engineering recombinase circuits for cellular diagnostic devices
Genetically engineered mammalian cells have demonstrated enormous clinical potential, especially as cancer therapy. Also, immune cells equipped with a single-input reporter circuit...
Regulation of phase separation in neuronal heterochromatin
ABSTRACT One of the most astonishing feats in all of biology is the process by which chromatin, the complex of DNA, histone proteins and associated factors, becomes compacted from...
Evaluating the therapeutic potential of hypoxia mimetics in inflammatory demyelinating disease
Multiple sclerosis (MS) is a chronic inflammatory disease that results in demyelination and degeneration of axons in the central nervous system (CNS). Disruption of the blood-brain...
Psychobiological regulation and molecular characterization of cell-free mitochondrial DNA in humans
PROJECT SUMMARY Mitochondrial signal transduction is an emerging biological pathway linking adverse psychosocial exposures to disease risk. However, we lack scalable, sensitive, an...
Systems Metabolic Approach for Multi-scale Pancreatic Cancer Phenotyping
ABSTRACT Pancreatic cancer is an aggressive, painful malignancy with a 5-year survival rate of less than 5% and median survival of about 4 to 24 months. The overall lack of success...
Characterizing gastrointestinal disorder trajectories for autistic sub-groups: Machine learning prediction of risk profiles and response to treatment
PROJECT SUMMARY/ABSTRACT Gastrointestinal (GI) problems are one of the most common concerns reported by families of autistic children and youth and can have significant lifelong im...
PP2A/B55alpha substrate specificity and function in cell cycle progression
The goal of this proposal is to fully delineate the molecular mechanisms by which the prominent serine/threonine Protein Phosphatase 2 (PP2A) holoenzyme, specifically PP2A/B55α, re...
Targeting olfactory neural pathways to combat obesity
PROJECT SUMMARY The sense of smell mainly plays a priming role in eating behavior. Recently, we observed that relatively long time food (chow)-derived odor exposure suppresses both...
Elucidating novel mechanisms for pancreatitis through calcineurin signaling
PROJECT SUMMARY. Acute pancreatitis (AP) is an exquisitely painful, life-threatening, public health problem that has substantial morbidity and limited treatment modalities. Our lon...