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99,167 grants found
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Lymphedema Prevention Through Immediate Lymphatic Reconstruction
PROJECT ABSTRACT Lymphedema is a debilitating, life-long iatrogenic sequalae of cancer treatment which is becoming an important survivorship issue due to improved cancer survival....
Role of SMARCD3/BAF60C in medulloblastoma
Project Summary/Abstract Medulloblastoma (MB), a fast-growing and heterogeneous brain tumor arising in the cerebellum, has been characterized as four major subgroups: WNT, SHH, Gro...
Testing a brief eHealth parent-focused prevention intervention with parents referred from primary care clinics
ABSTRACT Child and adolescent behavioral health problems are related to the leading causes of youth morbidity and mortality and are costly to society. Parent-focused interventions...
Socioecological Study of Autism, Suicide Risk, and Mental Health Care: Multilevel Analyses and Community Consultation for Suicide Prevention
Autistic people are at increased risk of suicide behaviors (SB), including suicidal ideation and suicide attempts, and have higher rates of suicide death compared to non-autistic p...
Novel oxygen monitoring system for on-site use in the clinic
PROJECT SUMMARY Knowledge of tissue oxygen levels has enormous clinical significance for accurate prognosis and treatment of several pathologies including cardiovascular diseases,...
Functional characterization of the endothelial cell niche for hematopoietic stem cells
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.During fetal life or in adulthood, hematopoietic...
Increasing the efficacy of non-activated CAR T cells by modulating IFN1 signaling
Chimeric antigen receptor (CAR) T cells have demonstrated their efficacy in treating blood-based cancers. However, the durability of responses is often hindered by challenges relat...
SEMA7a regulation of tooth mineralization, root elongation, and innervation
PROJECT SUMMARY/ABSTRACT The development of healthy molar teeth with elongated roots, mineralized dentin, and sensory innervation re- quires coordinated efforts between neuronal an...
Live embryo imaging for biopsy-free aneuploidy detection
PROJECT SUMMARY Preimplantation genetic testing for aneuploidy screening (PGT-A) is now widely used to decrease early pregnancy loss and to increase pregnancy rates, especially in...
Molecular mechanisms of motor skill stabilization
PROJECT SUMMARY Successful motor skill learning is marked by decreased performance variability over time. For motor skills learned during early developmental time periods, such as...
AAV Gene Therapy for Sialidosis: from Mice to IND
Project summary Siladosis is a rare, lysosomal storage disorder that causes fatal neurological disease that has no effective therapy. It is caused by loss of function mutations in...
Efficacy and Sustainability of a CarePartner-Integrated Telerehabilitation Program for Persons with Stroke
Project Summary/Abstract: Our long-term goal is to optimize stroke recovery by developing family-centered rehabilitation interventions that support continued and progressive functi...
Impact and Utilization of Scalable Functional Assays in Alagille Syndrome
PROJECT SUMMARY/ABSTRACT Uncertainty in our understanding of the functional impact of variation in the human genome has grossly impeded our ability to realize the full potential of...
Characterization and Modulation of Functional Connectivity and Fear Extinction Abnormalities in Obsessive-Compulsive Disorder
ABSTRACT Approximately 60% of patients with obsessive-compulsive disorder (OCD) respond to the psychotherapy of choice, exposure and response prevention (ERP). Unfortunately, troub...
Mitigation of Cerebral Infarct Growth in Acute Ischemic Stroke Using a Novel Blood Substitute
Project Summary/Abstract The aging of the population in industrialized nations is increasing the number of ischemic strokes that present in the emergency rooms of hospitals. In the...
Programmable and Conditional Proteolysis Targeting Chimeras Enabled by DNA Nanotechnology
SUMMARY/ABSTRACT Approximately 85% of the proteome is considered undruggable by traditional, occupancy-driven pharmacology employing small molecular inhibitors. Proteolysis-targeti...
Exploiting differences in HPV oncoprotein function among oropharyngeal cancers to personalize therapy
PROJECT SUMMARY Toxicities of treating human papilloma virus-related (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) with radiation plus cisplatin create lifelong disabiliti...
Cytoskeletal compartmentalization of apoptotic signaling
PROJECT SUMMARY The actin cytoskeleton impacts virtually every function of a human cell. Sophisticated regulatory mechanisms ensure that actin polymerizes when and where it is need...
New Approaches for the treatment of Hypothyroidism
Project Summary This submission is in response to PAS-23-086, Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK. Hypothyroidism is a common condition as...
Mechanisms of cognitive impairment caused by atherosclerosis and red blood cell released ATP
Project Summary With a fast pace of population aging, the prevalence of cognitive impairment and dementia including Alzheimer’s disease is expected to rise exponentially, placing a...