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99,167 grants found
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A liver-specific mitochondrial carrier that controls energy homeostasis
PROJECT SUMMARY Beyond ATP, mitochondria supply a variety of metabolites to the cytosolic compartment. Given the impermeable nature of the mitochondrial inner-membrane, mitochondri...
Adding Bright Light Treatment to Cognitive-Behavioral Therapy for Insomnia to Prevent Chronic Post-Surgical Pain in Older Adults
Preventing Chronic Postsurgical Pain (CPSP) and reducing postsurgical opioid exposure is a public health imperative. Perioperative insomnia is an increasingly recognized modifiable...
MINT conditioning to improve post-stroke gait
Stroke is one of the most common causes of long-term disability. About 60% of stroke survivors have impaired leg movement, leading to reduced walking speed and quality of life. One...
QALYs, Comorbidities, and Cost-effectiveness of HIV Care in the Department of Defense vs the Veterans Health Administration
QALYs, Comorbidities, and Cost-effectiveness of HIV Care in the Department of Defense vs the Veterans Health Administration I. ABSTRACT The challenges faced by people with HIV (PWH...
Improving HIV testing among Children under five in Rural Uganda
PROJECT SUMMARY AND ABSTRACT Prevention of mother-to-child transmission (PMTCT) programs have limited effectiveness in Sub-Saharan Africa, where the vast majority of perinatal infe...
Erythroid Self-Renewal
Self-renewal is the process by which a cell divides to generate daughter cells that have the same developmental potential as the parent cell. The overall goal of our collaborative...
Mechanical Regulation of PKA Function in Cell Adhesion and Migration
PROJECT SUMMARY Cell adhesion to the extracellular matrix (ECM) is fundamentally important to multicellular life. Focal adhesions (FAs) are the best characterized cellular structur...
Ameliorating Respiratory Neuromotor Dysfunctions in Aging and Alzheimer's Disease
ABSTRACT The studies in the proposal are focused on the neuromotor system in Alzheimer’s disease (AD) and natural aging. Increased age is associated with muscle atrophy and weaknes...
Redox regulation of protein kinase function: biochemical mechanisms and cellular consequences
SUMMARY. My research program focuses on understanding the organization and regulation of phosphorylation-dependent signaling networks in health and disease. In particular, we are i...
DEL Screening Campaign for Contraceptive and Cancer Targets
Project summary/abstract. The emerging field of allosteric inhibition of protein kinases has the potential to provide highly targeted therapeutics for diverse diseases without unde...
Automatic mode-dependent and phase-varying prosthetic foot stiffness modulation to improve balance control in individuals with lower-limb amputations
Project Summary Individuals with lower limb amputations are at higher risk of falling compared to able-bodied and other clinical populations and are more likely to sustain life-alt...
Leveraging metabolic pathways and gene expression data to propel understanding of severe obesity in a vulnerable and understudied population
ABSTRACT We know little about the mechanisms underlying a critical subset of heterogeneous obesity: Severe Obesity (SevO; BMI≥40kg/m2; ~>100 lbs overweight), a risk factor for a...
Developing a baboon model for uterine fibroids
By age 50, most women will have had uterine leiomyomas (fibroids) with a lifetime cumulative incidence of ~70% for White women and >80% for Black women. Approximately 25% of wom...
A novel, child-friendly, home-based navigation training program using joystick-operated ride-on-toys to improve upper extremity function in children with hemiplegia: A pilot study
Project summary/Abstract Hemiplegia is a very common pediatric developmental condition in the United States with roughly 4000 babies diagnosed every year. Children with hemiplegia...
Terahertz time-domain spectroscopic imaging of cornea for three dimensional mapping of hydration gradients
Project Summary There are several ophthalmological diseases and ailments that perturb the normal water content or hydration levels of the corneal layer. Among these, Fuchs’ dystrop...
ACE2-independent alternative receptors for SARS-CoV-2 at the oral mucosa
PROJECT SUMMARY Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major challenge for public health since the f...
Dietary Ketone Supplementation as a Novel Strategy to Attenuate the Adverse Vascular and Renal Consequences of High Dietary Salt in Older Adults
PROJECT SUMMARY Excess dietary salt is associated with increased risk for hypertension and cardiovascular disease (CVD), the leading cause of death in the United States. High dieta...
High resolution inflammatory networks induced by HIV reservoirs in adolescents
ABSTRACTAntiretroviral treatment (ART) for HIV infection effectively blocks viral replication, but fails to eradicate the virus, which can be a source of persistent inflammation. T...
Defining the mechanisms of the glycophagy shunt and its role in metabolism
Project Summary / Abstract Glucose metabolism is tightly regulated and has a central role in cell biology, while dysregulated glucose metabolism is a common occurrence in various m...
Point-of-Care Metagenomics for Rapid Detection of pathogens and Antimicrobial Resistance in Sight-Threatening Ocular Infections
PROJECT SUMMARY Timely and accurate diagnosis of ocular infections is critical to guide early effective therapy and save vision. However, because current methods for diagnosis of o...