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99,167 grants found
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The Role of Dystrophin in Synapse Development
Project Summary (Abstract): Duchenne muscular dystrophy (DMD), the most common form of childhood muscular dystrophy, is caused by mutations in the gene encoding the protein dystrop...
Identifying drivers of genital inflammation and HIV acquisition in women living in sub-Saharan Africa
PROJECT SUMMARY The majority of HIV worldwide is transmitted following heterosexual intercourse and women are twice as likely to contract HIV from heterosexual sex than men. Mucosa...
Eliciting Broadly Neutralizing Antibody Responses against HIV-1 Fusion Peptide Epitope by AB Toxin B Subunit-Based Immunogens
Developing a vaccine that can elicit broadly neutralizing antibodies (bnAbs) against HIV remains a significant challenge in the fight against HIV/AIDS. One major vulnerable site on...
Salmonella type III secretion: substrate targeting and injectisome assembly
Project Summary In the face of increasing antimicrobial resistance, understanding the mechanism of virulence factor(s) characteristics in bacteria is critical for developing new th...
Translational regulation of PGC1alpha and oxidative metabolism
PROJECT SUMMARY As the prevalence of obesity and associated disorders rises, manipulation of adipocyte energy expenditure has gained attention as a potential means to treat metabol...
Development of NLRP3 inhibitors for HIV-associated neuroinflammation in cocaine use.
ABSTRACT Despite the advances in antiretroviral therapy (ART) and its widespread use, cognitive impairment is commonly seen in HIV-1-infected patients. A salient feature of the HIV...
Early Life Phenotyping of Very Preterm Infants
PROJECT SUMMARY/ABSTRACT In the United States, over 60,000 infants are born very preterm (VPT, ≤32 weeks’ gestation) each year; more than 15% of these infants die in infancy, while...
Novel NF-kB variant in preeclampsia
SUMMARY Preeclampsia (PE) remains a poorly understood, multiorgan vascular disease that is responsible for the death of up to 50,000 women and 1 million infants per year. Defective...
Development of an intravenous CB1 antagonist for acute cannabinoid intoxication and cannabis hyperemesis syndrome
1 Cannabis is the most used psychoactive substance world-wide. The CNS effects of THC, the 2 main psychoactive constituent of cannabis, and synthetic cannabinoids are largely attri...
Dissecting the aging skeletal stem cell niche
PROJECT SUMMARY Maintenance, remodeling, and repair of the adult body is mediated by multipotent stem cells that give rise to a variety of cell types that comprise the tissue in wh...
A structurally suitable neck exoskeleton for amyotrophic lateral sclerosis
PROJECT SUMMARY Although static neck braces are prescribed to patients with head drop resulted from amyotrophic lateral sclerosis (ALS), many patients do not use these neck braces...
Identifying the radioprotective potential of radiation-resistant fungi using Drosophila
PROJECT SUMMARY: Ionizing radiation causes double strand breaks and damages the protein-based mechanisms responsible for their repair. This makes mitotic cells in the bone marrow,...
Acute effects of THC in older adults
ABSTRACT Background: The use of cannabis is growing in older adults but there is very limited high quality information on the acute effects of cannabinoids in healthy older adults....
Peptoid conjugates targeting prostate cancer
PROJECT SUMMARY We propose an innovative approach to antagonize the androgen receptor (AR) by displaying AR ligands on a peptoid scaffold. This new family of molecules, called mult...
Promotion of Exercise for Multiple Sclerosis through Physical Therapy (PromPT)
Project Summary/Abstract Multiple sclerosis is a debilitating disease usually diagnosed between the ages of 20 and 49-years with no curative options, resulting in a focus on rehabi...
Ankle contractures in muscular dystrophy: mechanisms and tissue adaptations
Project Summary/Abstract Ankle contractures in muscular dystrophy: mechanisms and tissue adaptations Duchenne muscular dystrophy (DMD) is a genetic disorder that causes progressive...
Quantifying Locomotor Outcomes with Agonist-Antagonist Myoneural Interface
Project Summary An innovative new surgical technique - the agonist-antagonist myoneural interface (AMI) - restores agonist-antagonist muscle dynamics in the residual limb to promot...
Quantifying Sex-Specific Musculoskeletal Adaptations to Wheelchair Use in Childhood and Adolescence
Project Summary Up to 70% of manual wheelchair users experience shoulder pain, and as many as 90% develop pathologies like rotator cuff tendinopathies and glenohumeral instability....
Towards real-time personalized brain state-dependent TMS to enhance poststroke hand rehabilitation
PROJECT SUMMARY Stroke commonly disrupts the corticospinal tract (CST) and impairs hand function, but current rehabilitation approaches incompletely restore pre-stroke hand motor c...
Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers
PROJECT SUMMARY/ABSTRACT Patients with lung cancer, on the most prevalent cancer diagnoses in the United States, tend to experience debilitating physical and psychological sequelae...