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Mapping and prediction of quantitative transcription factor dosage effects to understand variation in craniofacial morphology and disease
PROJECT SUMMARY Accumulating evidence suggests robustness of transcriptional regulation, yet human genetic studies indicate phenotypic sensitivity to transcription factor (TF) dosa...
Psychosocial Predictors of Risk for Suicidal Behavior Among Gender Minority Adolescents
Project Summary/Abstract In response to NOT-MD-22-012: Gender minority adolescents (GMAs; adolescents whose gender identity is different than their sex assigned at birth) have high...
Normobaric Oxygen Therapy for Spinal Cord Injury
ABSTRACT Spinal cord injury (SCI) interrupts blood flow, and the O2 partial pressure (PO2) in the injured spinal cord drops to near zero. This contributes to necrosis and secondary...
Magnetically Triggered Protein Release for Varying Severities of Spinal Cord Injury
Project Summary This R03 application aims to create innovative magnetically responsive drug delivery electrospun fibers to improve regeneration after spinal cord injury (SCI). Trau...
Defining the contributions of hypothalamic microglia and perineuronal nets to obesity pathogenesis
Project Summary An emerging model of obesity pathogenesis posits a central role for the inflammatory activation of hypothalamic microglia localized to the arcuate nucleus (ARC, a k...
Epitranscriptomic and post-transcriptional regulation of the RNome in gram negative and firmicute bacteria
PROJECT SUMMARY / ABSTRACT Post-transcriptional regulation of gene expression has significant effects on the physiology of the bacterial cells. While much has been uncovered about...
Antimicrobial blue light-activatable optical endotracheal tube to combat biofilms on the endotracheal tube
PROJECT SUMMARY/ABSTRACT Endotracheal intubation is a common hospital procedure implemented in patients requiring mechanical ventilation. However, biofilms formed on endotracheal t...
RNA regulation in germline development and fertility
Our research team explores genetic, molecular, and cellular interactions between germ cells and somatic (non-germline) cells of the gonad. We focus on the mechanisms regulating rep...
Examining the Mechanisms and Consequences of Sleep Health Inequities Affecting Black SexualMinority Men
PROJECT SUMMARY/ABSTRACT Black sexual minority men (SMM) suffer disproportionately from health inequities, including high rates of HIV, mental health issues, and poor physical heal...
Socioeconomic impacts of La Crosse encephalitis in western North Carolina
Project Summary La Crosse virus (LACV, family Peribunyaviridae, genus Orthobunyavirus) is the leading cause of arboviral pediatric encephalitis (neuroinvasive LACV disease; NLACVD)...
Biologic Encapsulation by Tuning their Organic Solubility with Amphiphilic Polymers
Project Summary Biologic encapsulation in polymers has long been utilized to control their release. While this approach may be well suited for hydrogels with an aqueous solvent, en...
Translational Programming of Beta-cells in Response to Glucose Toxicity
ABSTRACT Control of insulin biosynthesis in beta-cells occurs primarily at the level of translation of the insulin mRNA. An acute rise in glucose levels stimulates insulin translat...
Engineering ferritin degrader-encapsulated platelets for post-surgical TNBC treatment
PROJECT SUMMARY As an aggressive and invasive type of breast cancer, triple-negative breast cancer (TNBC) has limited effective treatment options in the clinic. Chemotherapy, repre...
Contribution of the paternal histone epigenome to embryo development and pregnancy loss
PROJECT SUMMARY Pregnancy loss is estimated to affect approximately 30% of clinically defined pregnancies in the United States, however the actual number is likely much higher due...
Diet and the neurodevelopment of impulsivity
Project Summary Impulsivity refers to the propensity toward rapid action without forethought of the consequences and devaluing rewards that are delayed in time in favor of immediat...
Hijacking Post-translational Arginylation for Targeted Protein Degradation
Project summary Posttranslational arginylation on proteins installed by arginyltransferase ATE1 is a critical modification for cancer progression and metastasis. ATE1 is a benefici...
An Outcome-Focused Measure of Mental Health Care Quality based on Standardized Patient-Reported Symptoms
PROJECT SUMMARY / ABSTRACT There are various psychological, cognitive, behavioral, medication and neurostimulation treatments that can improve the outcomes of people with common de...
Integrated computational approaches to determine contributions of the oral virome
ABSTRACT The oral cavity is a complex environment where a diverse array of organisms coexists in dynamic interplay with the human immune system. While bacteria, archaea, and fungi...
Alcohol Tolerance as a Driver of Self-Administration
––– PROJECT SUMMARY ––––––– R21/R33: Alcohol Tolerance as a Driver of Self-Administration ––– PI: Rothenfluh ––– Alcohol use disorder (AUD) is still highly prevalent in the US, and...
Impact of maternal dietary vitamin A on risk and severity of cleft lip/palate in genetically sensitized embryos
Project Summary The term “Cleft lip with or without cleft palate (CL/P)” encompasses a variety of clinical presentations that collectively represent one of the most common human bi...