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99,167 grants found
Showing 3,521 – 3,540 of 99,167 grants
Identification of essential biomarkers in the polyploid cancer cell lifecycle
PROJECT SUMMARY Whole-genome duplication (WGD) is increasingly appreciated as a defining moment for enabling chromosome instability in solid tumors. This proposal investigates chem...
CMV+ milk: morbidity risk & translational potential of neutralizing antibodies
PROJECT SUMMARY/ABSTRACT Over one-half the population of childbearing age women are cytomegalovirus (CMV) seropositive. More than 90% of CMV-seropositive women will shed the virus...
Comorbidities in Pregnant Women with Prenatal Alcohol Exposure and Adverse Birth Outcomes
Abstract In the last three decades, extensive research has been conducted on the effects of prenatal alcohol intake on birth outcomes, fetal alcohol spectrum disorders, and childre...
Development of in vitro human spinal neural tube model to study genetic and environmental etiology of Spina Bifida.
PROJECT SUMMARY Spina bifida (SB) is a viable type of neural tube defect (NTD), the second most prevalent birth defect in humans. The genetic and environmental factors combinatoric...
Navigating Financial and Health-Related Social Needs in Adolescent and Young Adult Cancer Survivors (AYA-NAV): A Digital Intervention Pilot Study
Adolescent and young adult (AYA) cancer survivors represent a growing population due to recent advances in cancer treatment. AYA survivors, defined by the National Cancer Institute...
Targeted Degradation of HIV Integrase as a Novel Treatment of Infection
Targeted Degradation of HIV Integrase as a Novel Treatment of Infection PROJECT SUMMARY Due to the development of antiretroviral therapy, HIV-1 infection is no longer a death sente...
Chaperoning Preassembly Modules for Mitochondrial Ribosome Assembly
Henry, Michael F. Abstract The goal of the proposed research is to define the mechanisms of ribosome assembly within mitochondria. While remarkable progress has recently been made...
Novel Mcl-1 Inhibitor for Combination Treatment of Refractory Multiple Myeloma
ABSTRACT Multiple myeloma (MM) is a plasma cell malignancy. Treatment usually involves a proteasome inhibitor, dexamethasone, and an immunomodulatory or chemotherapeutic treatment,...
Sensitive Treponema pallidum genome recovery through tiling amplicon sequencing
Project Summary Sensitive Treponema pallidum genome recovery through tiling amplicon sequencing Genomic epidemiology is now a standard part of the public health response to outbrea...
REACH-EpiVCID
Caused by advanced cerebral small vessel disease (CSVD), intracerebral hemorrhage (ICH) leaves survivors with a very high risk of incident vascular cognitive impairment and dementi...
Deep mutational scanning of MYH7 in genome-edited cardiomyocytes
Project Summary Hypertrophic cardiomyopathy (HCM) is a heritable hypertrophy of the left ventricle that can present as sudden cardiac death and heart failure. Autosomal dominant mi...
Develop a wireless, skin-conformable and dual-sensing wearable system in support of voice and upper airway telehealth care
PROJECT SUMMARY Voice and upper airway (VUA) disorders affect nearly 30% of the general population and 80% of occupational voice users in the United States. Patients experience sym...
Pathogenic mechanisms of adult hearing loss caused by Zfp719 mutations
Project Description Hearing loss is the most prevalent sensory deficit in humans. Half of all cases of early onset hearing loss in developed countries have a genetic etiology, with...
Investigating electromagnetic field-based neuromodulation of slow-wave brain activity and glymphatic system
Abstract The role of glymphatic system for brain health has been established in recent studies. Specifically, the removal of brain waste from the brain parenchyma through the cereb...
Inhaled ciclesonide - a phase I study in preterm infants
Preterm infants born before 30 weeks gestation are at risk of developing bronchopulmonary dysplasia (BPD), a leading cause of death and long-term pulmonary insufficiency. Both hydr...
Interrogating the Role of Bacterial Methyl-modifying Enzymes in Pathoadaptation and Host Epigenetic Interference in Cancer
PROJECT SUMMARY/ABSTRACT The proposed study seeks to determine if DNA methyltransferases from members of the microbiota contribute to bacterial pathoadaptation in the tumor niche,...
Developing and testing a digital health tool for INterseCtional stigma assessment and reduction at multiple Levels and mUltiple DimEnsions (INCLUDE) to improve HIV care in ART centers in Nepal
Project Abstract People living with HIV (PLWH) have poor clinical outcomes when they are excluded from care due to intersectional stigma related to HIV, mental health (MH), and oth...
Addressing Research Gaps to Optimize Dolutegravir-based ART in Children and Adolescents
ABSTRACT Despite the major advances in the treatment of human immunodeficiency virus (HIV) and HIV-associated comorbidities, the adoption of newer regimens in children has fallen f...
Immune Microenvironments That Impact HIV Persistence and Expression During ART
ABSTRACT A formidable barrier to a cure for HIV-1 infection is the existence of latently infected cells that sporadically activate HIV transcription during antiretroviral therapy (...
Investigating Syphilis Pathogenesis Through Genetic Engineering of Treponema pallidum
ABSTRACT In several high-income nations, including the United States, infectious syphilis has been resurgent for over two decades now, while syphilis is still endemic in low- and m...