Browse All Grants
99,167 grants found
Showing 3,501 – 3,520 of 99,167 grants
An Observational Study of IL1 Inhibition for Blocking ACVR1-Induced Flare Activity and Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva
PROJECT SUMMARY Abnormal responses to inflammatory stimuli can lead to severe inflammation, acute tissue damage, and long- term scarring or fibrosis. One example is the rare diseas...
ASSESSING PSYLLIUM GIVEN WITH MEALS FOR FRUCTAN SENSITIVITY IN CHILDREN WITH IRRITABLE BOWEL SYNDROME
PROJECT SUMMARY Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction that affects up to 20% of school children worldwide. Dietary interventions, particularly those...
Predicting recovery after TBI: Development and comparison of MR-supplemented models using non-parametric and machine learning multimodal fusion
Project Summary/Abstract (30 lines max) The ability to leverage early biomarkers, clinical, and demographic data to accurately predict a patient’s likely recovery trajectory follow...
Elucidating the role of luminal pH in regulating phagosome transport
Project Summary/ Abstract Macrophages capture harmful microbes by engulfing them and forming dynamic organelles called phagosomes. Following internalization, phagosomes undergo a g...
Phosphorylation of α/β Tubulin is a 'Toggle Switch' in Human Breast Cancer
“Phosphorylation of α/β-Tubulin is a ‘Toggle Switch’ in Human Breast Cancer The α/β-tubulin heterodimer is the building block of microtubules (MTs) which comprise an essential comp...
DNA Methylation Dynamics of Mammalian Development
PROJECT SUMMARY The progression from a pluripotent state into the myriad cell types that arise during mammalian development involves a host of epigenetic properties that dictate ge...
Polyamine modification of host immune responses and oxidative balance in the cervicovaginal space: potential mechanisms governing cervical remodeling in preterm birth
PROJECT SUMMARY Specific microbial and immune features of vaginal ecosystems, including a Lactobacillus-deplete microbiota, have been linked to spontaneous preterm birth (PTB). Mec...
The roles of mouse Y chromosome Zfy genes in male reproduction.
Project Summary The Y chromosome encoded zinc finger gene, Zfy, has once been in the center of attention as a potential candidate for the testis-determining factor. When the fame w...
A New Foundation: Advancing Adolescent Neglect Science through Measurement Development
PROJECT SUMMARY The neglect of children and adolescents, a form of maltreatment along with abuse, is a significant problem that impairs health and well-being throughout the lifespa...
Mapping the virus-host interactions that determine interferon resistance of Seoul orthohantavirus
Mammalian hantaviruses (order Bunyavirales, genus Orthohantavirus) are zoonotic RNA viruses that cause severe vascular inflammatory disease in humans, with case-fatality rates of u...
Wetlands in Argentinaas hubs for exchange and emigration of bird-borne arboviruses
Abstract Arthropod-borne viruses (arboviruses) are emerging at an unprecedented rate due to cultural, biological, environmental, climatic, and social changes. Historically, conside...
Integrated proteomic and metabolomic biomarker profiling for understanding metabolic syndrome in pregnant women living with HIV on Tenofovir Disoproxil Fumarate/Lamivudine/Dolutegravir (TLD)
PROJECT ABSTRACT/SUMMARY Effective HIV treatment during pregnancy is critically important, both for the health of women living with HIV (PWHIV) and for prevention of perinatal HIV...
Evaluation of PrEP implementation strategies for the general population in Botswana
PROJECT SUMMARY While Botswana has attained the UNAIDS 95-95-95 target for HIV treatment and is the first country with severe HIV epidemic to reach the milestone of elimination of...
In Vitro Identification of miR-718 targets and miR-718-induced epigenetic modifications
Abstract Epigenetic modifications are now recognized as contributing factors in many diseases. Modifications in gene expression can be induced by DNA methylation/hydroxymethylation...
Real-time mapping of neuronal connectivity at a synapse resolution
Summary Synapses, the connections between neurons, play a crucial role in determining circuit connectivity and function. Visualizing their structure and dynamics is challenging due...
Investigate the Neural Circuits of Infant-Directed Behaviors
SUMMARY STATEMENT Parental care is an innate social behavior essential for species survival. Hence, a hardwired circuit has evolved to support its expression. However, naïve animal...
Role of neurexin in social adaptation and amygdala plasticity
Project summary Social relationships benefit mental and physical health, while poor quality social interactions are associated with worse health and higher mortality. The abilities...
Pathophysiological mechanisms in the brain's endogenous glucagon-like peptide 1 system mediated by obesogenic diets
Title: Pathophysiological mechanisms in the brain’s endogenous glucagon-like peptide 1 system mediated by obesogenic diets Pharmacotherapies that target the glucagon-like peptide 1...
Oxytocin for induction of labor: understanding goals and mechanisms
PROJECT ABSTRACT Nearly a third of pregnant patients in the US undergo induction of labor with oxytocin. Despite it being a commonly used medication on Labor & Delivery units a...
Topical Neurokinin-1 Receptor Antagonist as an Effective Non-addictive Analgesic for Ocular Pain
PROJECT SUMMARY / ABSTRACT The cornea is the most densely innervated tissue of the body, making it vulnerable to various insults and neurosensory abnormalities that can lead to sev...