Browse All Grants
99,167 grants found
Showing 3,481 – 3,500 of 99,167 grants
Engineered orthogonal signaling systems for selective phosphorylation of protein kinase substrates
ABSTRACT Protein kinases function in cell signaling through regulated phosphorylation of specific substrates. Current methods allow one to comprehensively identify the substrates o...
Brain-computer interface (BCI)-based identification of color vision deficiencies (CVDs) related to Parkinson’s Disease (PD)
Project Summary/Abstract Parkinson’s disease (PD) reduces the voluntary movements, emotional expressions, and life expectancy of about one million Americans. Early identification a...
Neural basis of visual attention in the primate brain
PROJECT SUMMARY Natural scenes are cluttered with multiple objects that compete for neural representation due to limited processing capacity. Mechanisms for selective processing, b...
Development of a system to protect and concentrate large DNA for genome analysis
PROJECT SUMMARY/ABSTRACT Structural variation alters approximately 3.4 times more base pairs than point mutations within the human genome. Structural variations, such as amplificat...
Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM)
PROJECT SUMMARY For the more than 200,000 women who develop hormone receptor positive breast cancer yearly, endocrine therapy for at least five years reduces cancer recurrence by n...
Decoding the BETA-arrestin2-LMBRD2 cascade in ALPHA-synuclein pathogenesis.
The defining pathological hallmark of Lewy body diseases (LBDs) is the accumulation of misfolded a-synuclein (aSyn) aggregates, which are heavily phosphorylated at Ser129 (pS129-aS...
Symptom Management and Transitioning to Engagement with Post-treatment Care for Adolescent and Young Adult Cancer Survivors (AYA STEPS)
There are more than 600,000 adolescent and young adult (AYA; age 15-39 at diagnosis) cancer survivors in the U.S. The number of AYA survivors continues to grow due to both an incre...
The Impact of Oral Contraceptives on Neuron-derived Exosomal miRNA Expression in the Developing Brain
Project Summary Oral contraceptives (OCs) contain synthetic estrogen and progesterone and are prescribed to millions of women in the United States for some period during their repr...
Development of Memory Networks in Children
PROJECT SUMMARY/ABSTRACT The human ability to retrieve information from past experiences is essential for everyday living, shows robust improvement across childhood, and is impaire...
Maternal regulation of microtubules in egg developmental competency
Project Summary Vertebrate eggs lie dormant until fertilized, when a process called egg activation ensues that triggers the completion of meiosis and other processes that initiate...
Targeting CD127-expressing tissue reservoir cells as a strategy for HIV cure
PROJECT SUMMARY Homeostatic proliferation, in particular that mediated by IL7, is an important driver of HIV persistence in CD4+ T cells. We recently established that CD127, the al...
Strengthening informed consent for authentic participation in perinatal HIV research
Project Summary The field of maternal-infant HIV research has been especially attuned to the challenges of attaining authentic informed consent in low-literacy populations affected...
Architecture and dynamics of immature HIV lattice
Project Summary: Our long-term goal is to gain a molecular understanding of the machinery that regulates the assembly, release, and maturation of infectious HIV virions. Newly rele...
Understanding reservoir effects and curative potential of a CD3/CCR5 bispecific antibody in infant macaques
The goal of this project is to understand reservoir effects and curative potential of a promising CCR5-depleting bispecific antibody (bsAb) given with days of ART initiation to inf...
Extracellular vesicles in Environmental Epidemiology Studies of Aging
SUMMARY Through this RIVER proposal, I seek support to characterize and understand early biological responses that anticipate age-related disease, which typically develops from exp...
Synthetic Genetic Controller Circuits for Transcription Factor-Directed Differentiation
PROJECT SUMMARYThe ultimate goal of this project is to create synthetic genetic circuits that accurately control the level of cell fate- specific transcription factors (TFs) autono...
Dynamics and Evolution of HIV Gag and GagPol processing
SUMMARY Maturation of the HIV-1 capsid requires activation of the viral protease (PR) and proteolytic processing of the Gag and GagPol polyproteins. Previous studies support a mode...
Novel B. Pertussis vaccines that elicit mucosal immunity
Project Abstract Despite high global vaccination rates, pertussis caused by the gram-negative bacterial pathogen Bordetella pertussis (Bp) is re-emerging in vaccinated individuals....
HRV-guided tDCS: Integrating a biomarker for clinical utility
PROJECT SUMMARY / ABSTRACT Transcranial direct current stimulation (tDCS) is a method of noninvasive brain stimulation that is effective for neuropsychiatric symptom targeting when...
Parkin tumor suppression
PROJECT SUMMARY The loss of endogenous tumor suppressors is an obligatory step in tumor onset and progression, but the underlying mechanisms are elusive and the breadth of their ta...