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99,167 grants found
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A secure analytics platform to study the prognosis of people with HIV in the USA, Canada and Europe and comparative effectiveness of treatment regimens: the Antiretroviral Therapy Cohort Collaboration
PROJECT SUMMARY/ABSTACT The HIV epidemic has changed dramatically since the introduction of effective antiretroviral therapy (ART), which substantially increased the life expectanc...
Revealing new short tandem repeat variation in the human population across sequencing technologies: towards rare disease diagnosis and discovery
Abstract Short tandem repeats (STRs) are 1–6 bp repetitive and highly polymorphic DNA sequences. Expansions in dozens of STRs are associated with genetic disease. However, STRs are...
Exploration of D-Glucose and D-Mannose Metabolism to Target arenaviruses
PROJECT ABSTRACT/SUMMARY The viruses belonging to the family Arenaviridae contain several causative agents of hemorrhagic fever in humans. For instance, Lassa virus causes Lassa fe...
Host-virus interactions in hantavirus glycoprotein assembly
PROJECT SUMMARY/ABSTRACT Rodent-borne orthohantaviruses (hereafter, hantaviruses) are an important group of zoonotic bunyaviruses associated with over 50,000 annual diagnosed cases...
Deciphering Cellular and Genetic Features that Give Rise to Osteonecrosis of the Jaw
ABSTRACT Osteonecrosis of the jaw (ONJ) is a damaging condition characterized by exposed and necrotic bone in the maxillofacial region, and arises most commonly in patients taking...
Ultrasound Cavitation for Facilitated Cardiac Transduction of AAV
SUMMARY There is intense interest in gene therapy for the treatment of a wide variety of inherited and acquired cardiovascular diseases. Yet, progress in this field has been limite...
Mechanisms of Silent Synapse Maturation for Excitatory Network Refinement
Abstract Silent synapses are instrumental in experience-dependent cortical network reorganization. This process is particularly prevalent during developmental critical periods when...
Appetite regulation with DTG based ART in postpartum women living with HIV and their infants (Ar-DART)
Project Summary Weight gain with Dolutegravir (DTG), an integrase strand transfer inhibitor (INSTI), has been observed in People living with HIV (PLHIV) including postpartum women....
Romosozumab as an adjunct to physiologic estrogen replacement in adolescents and young adults with functional hypothalamic amenorrhea
Abstract Low bone mass is a major co-morbid complication of functional hypothalamic amenorrhea (FHA) in adolescents and young adult women, including those with anorexia nervosa (AN...
Implementation strategies for caregiver and teacher use of behavioral interventions with ADHD: A pilot study
PROJECT SUMMARY Well-established psychosocial interventions for children with or at-risk for ADHD include behavioral parent training at home and behavioral classroom management int...
Driving Environmental Justice: Community Monitoring of Diesel Truck Emissions and Impacts onAsthma Morbidity in Immigrant Communities
ABSTRACT Asthma prevalence and morbidity is on the rise for recently migrated and multigenerational immigrant communities. It is well established that length of stay in the U.S. an...
Overcoming Therapy Resistance in Fusion Oncoprotein Driven Pediatric Leukemia
PROJECT SUMMARY Leukemia represents the most prevalent form of cancer among children. Sequencing studies from identical twins indicate that the initial genetic alterations can mani...
Viscerosensory Modulation of Brain Circuits in Larval Zebrafish
Project Summary/Abstract How brain circuits are modulated by sensory signals from internal organs (viscera) during ethologically relevant behaviors is a fundamental, yet largely un...
Dietary iron requirements in a diverse group of US adults
Project Summary/Abstract The Dietary Reference Intakes (DRIs) for iron were first established in 2001, drawing upon the best available data at that time. However, the committee was...
Microbiome mediated effects of gender affirming hormone therapy in mice
PROJECT SUMMARY Gender affirming hormone therapy (GAHT) is used by transgender (TG) people to alleviate gender dysphoria. GAHT for male to female TG subjects (transwomen) consists...
Wood Pellet Emissions and Children's Environmental Health in Mississippi
Abstract Children living near industrial activities are at a heightened risk of poorer health, including stress, asthma, and other respiratory illnesses. An increased understanding...
Assessing RF heating of active implantable medical devices in low-field MRI systems
PROJECT SUMMARY Implantable medical devices are on the rise, both in the US and worldwide. Over 12 million Americans rely on a cardiac or neuromodulation device, and this number in...
The effects of gender-affirming sex steroids on brain development in adolescents
Transgender and gender-nonbinary (TNB) adolescents may receive gender-affirming hormone therapy (GAHT) with estradiol or testosterone to induce desired secondary sex characteristic...
The KChIP2-JNK2 axis as a therapeutic target for sudden cardiac death
Project Summary Half of heart failure (HF) patients die suddenly, termed as sudden cardiac death (SCD), while HF affects over 5 million people in the United State alone. The curren...
Maternal B cells in health and disease.
PROJECT SUMMARY A detailed understanding of B cell and antibody responses to placental versus foreign antigen will illuminate how dysregulated responses contribute to pregnancy com...