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99,167 grants found
Showing 3,441 – 3,460 of 99,167 grants
Targeted antibiotic therapy for Shigella among children in low-resource settings
PROJECT SUMMARY/ABSTRACT Shigella is a leading cause of diarrhea and associated mortality among children under 5-years of age in low- and middle-income countries. Targeted antibiot...
Automated methods for standardization and enhancement of metadata in biomedical databases
PROJECT SUMMARY/ABSTRACT Biomedical research data sets are increasingly being deposited in public, centralized databases, such as the Sequence Read Archive (SRA), to which research...
Renal acid ceramidase-S1P pathway in salt-sensitive hypertension
Sphingolipid metabolites are recently emerging as important lipid signaling molecules. Among them, sphingosine-1-phosphate (S1P) is known to play critical roles in cellular process...
Combination metabolic therapy for diffuse midline glioma
PROJECT SUMMARY Diffuse midline gliomas (DMGs) are devastating primary brain tumors in children. Patient prognosis is abysmal with median survival of ~9 months after initial diagno...
Identifying and addressing bias in depression and anxiety quality measures
Summary RFA MH-23-265 identifies a crucial need for validated outcome-focused quality measures to incentivize quality improvement, inform consumers’ choices regarding care provider...
Assessment of a recently developed boron-based HIF inhibitor as a prospective therapy for renal cell carcinoma (RCC)
Inactivation of the VHL tumor suppressor protein (pVHL) is frequently observed in clear cell Renal Cell Carcinoma (RCC). The mutated pVHL does not bind and degrade the regulatory α...
PRecision IMaging to Evaluate Kaposi Sarcoma (PRIME-KS)
ABSTRACT Monitoring treatment response for Kaposi sarcoma (KS) using present clinical judgement is inadequate. While objective monitoring of KS lesions can be performed, the measur...
Investigating the impact of COVID-19 pandemic child care closures on developmental outcomes of young children in low-income families
Project Summary / Abstract The COVID-19 pandemic exacerbated many existing inequalities, including access to child care, education, and family support services. Children in low-inc...
DELTA ECMO ABI study (Assessing Acute Brain Injury after Rapid Reduction of PaCO2 upon ECMO Cannulation using Portable MRI and Biomarkers)
PROJECT SUMMARY/ABSTRACT … Extracorporeal Membrane Oxygenation (ECMO) is a life-saving therapy for people with severe heart and lung failure, and its use as therapeutic support con...
Psychosis in Ancestrally Diverse Settings (PADS)
PROJECT SUMMARY/ABSTRACT This project is a collaboration between SUNY Downstate Health Sciences University (Brooklyn, NY), the University of Ibadan (Ibadan, Nigeria) and the Univer...
Investigation of the serine protease Masp1 as a novel regulator of Bmp signaling during early embryonic development.
PROJECT SUMMARY Disruption of developmental processes, often due to genetic mutation, can lead to structural birth defects that have life-long consequences for affected individuals...
Deciphering the role of METTL3 in Mammalian Placenta Development and Maintenance Across Pregnancy
Abstract Placental dysfunction leads to pregnancy-associated disorders, including intrauterine growth restriction (IUGR) and preeclampsia, and also serves as a developmental cause...
Investigating mechanisms underlying diabetes associated with exocrine pancreas diseases
Summary Exocrine pancreas diseases like chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) can engender type 3c diabetes mellitus (T3cD: also called pancreatogen...
Understanding Schizophrenia Risk Mechanisms Via Multimodal Analysis of Patient-derived Neurons and 3D Cortical Organoids and Correlation with Clinical and Cognitive Phenotypes
PROJECT SUMMARY: Schizophrenia (SCZ) is a complex polygenic disorder, encompassing a spectrum of positive and negative clinical symptoms and cognitive deficits that vary considerab...
Rewiring T cell exhaustion with immune checkpoint blockade therapy
PROJECT SUMMARY The goal of this project is to determine whether it is possible to promote the development and/or maintenance of CD8+ T cells that are essential for anti-tumor resp...
Role of FGF21 in DMD
PROJECT SUMMARY Duchenne Muscular Dystrophy (DMD) is the most common muscular dystrophy seen in children, which affects both muscle and bone. To date, the mechanisms that contribut...
Early Predictors of Infant-Parent Coordinated Attention and Word Learning in Preterm and Full-Term Infants
PROJECT SUMMARY Preterm birth (PT,
Personalized Computational Modeling for Predicting Hemodynamics in Borderline Left Ventricles
The decision to perform a biventricular repair (BiVR) or single ventricle palliation (SVP) in patients born with a borderline left ventricle (BLV) remains challenging and subjectiv...
New Von Hippel Lindau (VHL) tumor suppressor signaling in renal cancer
Project Summary Clear cell renal cell carcinoma (ccRCC), which accounts for approximately 85% of all renal cancers, is resistant to a variety of cancer therapies and is highly leth...
Short-course rifapentine for TB prevention for all: clinical pharmacology matters
PROJECT SUMMARY Tuberculosis (TB) is the leading cause of death among people with HIV (PWHIV), and the risk of morbidity and mortality is also high among young children and pregnan...