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99,167 grants found
Showing 3,421 – 3,440 of 99,167 grants
Core 1 Administrative Core
Summary/Abstract Administrative Core #1 Resistance to our major antibiotics has been identified by the CDC as a major threat to the health and safety of the American public. Two of...
Core 2 Mechanistic Assay Core
Project Summary/Abstract: Mechanistic Assay Core #2 Carbapenem-resistant Acinetobacter baumannii (CRAB) and Klebsiella pneumoniae (CRKP) were categorized in the highest threat cate...
Core 3 Math Modeling Core
Summary/Abstract Mathematical Modeling Core #3 The overarching Aim of this proposal is to markedly improve therapeutic regimens for patients with high burden bacterial infections l...
Project 1 Mechanistic Project
Project Summary/Abstract Project #1 Acinetobacter baumannii (AB) and Klebsiella pneumoniae (KP) are bacterial “superbugs” listed in the highest threat category (‘Urgent’) by the Un...
Exploring Mechanisms Linking Maternal Childhood Adversity to Adolescent Psychopathology: The Role of Early Childhood Deprivation and Threat
Project Summary This developmental R21 study proposes a secondary data analysis addressing specific questions regarding the mediating pathways by which childhood maltreatment (CM)...
Chimera-BONCAT: A novel in vivo model for in-depth characterization of the human microglial response to alcohol
ABSTRACT Alcohol use disorder (AUD) is a significant health crisis in the U.S., which can result in numerous damaging effects on multiple organ systems including the brain. Althoug...
Noninvasive and early detection of endometriosis using a biological neural circuit-based novel gas sensor
PROJECT SUMMARY Endometriosis is a chronic inflammatory estrogen-dependent disease, and it affects approximately 10-15% of women of reproductive age. Definitive diagnosis of endome...
Risk, Resilience, and Recovery: A Longitudinal Mixed-Method Study Examining the Role of Peer Relationships in Pediatric Pain
Project Summary/Abstract Pediatric chronic pain is a critical public health problem, affecting up to a third of adolescents and contributing to significant emotional distress, poor...
In vitro and in silico investigations of changes in bacterial cell membrane dynamics due to polyunsaturated fatty acid (PUFA) modifications
Project Summary/Abstract Bacterial responses to fatty acids include, but are not limited to, degradation for metabolic gain, modification of membrane lipids, alteration of protein...
Electrical Field Guided TMS and Constraint Induced Language Therapy to TreatPost-Stroke Aphasia in the Subacute Stage
Project Summary Transcranial Magnetic Stimulation (TMS), sometimes in conjunction with Speech-Language Therapy, has been demonstrated to improve language function in subjects with...
Psychophysical distillation of pure pain by nociceptive-specific heating
Project Summary: Experimental pain testing in humans, including both quantitative sensory testing (QST) and functional magnetic resonance imaging (fMRI), is widely used to make inf...
Air Pollution and Mortality Risk in Veterans with Chronic Respiratory Disease: Assessing the Role of Individual and Place-Based Risk Factors
PROJECT SUMMARY/ABSTRACT Chronic respiratory diseases (CRD), such as asthma and chronic obstructive pulmonary disease, impact over 554 million people worldwide and are major contri...
Increasing Access and Participation to Early Phase Clinical Trials to the Underrepresented Populations
Project Summary Access to health care including clinical trials leading to paradigm-changing cancer treatments is critical for high quality cancer care and equity in society. Diffe...
Hormonal Programming of the Mesocorticolimbic Circuit During Adolescent Development
Abstract Adolescence is a critical period for the development of a range of mental health conditions in females and males, particularly those marked by impairments in cognitive con...
Identification of HIV Rev-Rev interaction inhibitors by a high throughput, small molecule, cell-free screen
The HIV pandemic has grown to ~40 million individuals world-wide. Although Highly Active Anti- Retroviral Therapy (HAART) has been transformative for millions of people, less than...
Ionic liquid-based nanoemulsion containing combination antiretroviral drugs forthe transdermal treatment of pediatric HIV infection
PROJECT SUMMARY The effective long-term management of HIV infection in pediatric patients faces a multitude of challenges such as lack of age-appropriate pediatric formulations, hi...
Long-term clinical and immunologic consequences of inflammation in perinatal HIV
Project Summary Globally, 2.7 million children are living with HIV and 270,000 new infections occur annually. With antiretroviral therapy (ART) that suppresses viremia these childr...
HIV Vaccine Design Incorporating Selective Avidity
ABSTRACT VRC01 is prototypical broadly neutralizing antibody (bnAb), capable of neutralizing diverse HIV strains. Vaccine-based shepherding of VRC01 germline-reverted B-cells to th...
Characterizing Latino Caregiver Engagement in Early Intervention Services for Autism
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Children with autism spectrum disorder (ASD) are...
Molecular Mechanisms of Clarin-1 and Clarin-2 function in mechanosensory hair cells
SUMMARY The long-term goal of my laboratory is to elucidate the mechanisms that regulate the development and function of hair bundles of cochlear hair cells, and how defect in hair...