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99,167 grants found
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The Personalized Remote Radiation Tracking Portable Organ Dosimetry Devise (PRRT PODD)
Theranostics is a type of precision medicine in which targeted radiolabeled compounds are being used for both diagnosis and treatment. Targeted therapies can increase therapeutic e...
Molecular and bioenergetic dynamics of in utero chronic hypoxia on placenta and brain
PROJECT SUMMARY Insufficiency of the placenta due to conditions such as hypertension, diabetes, and fetal congenital heart disease can lead to chronic in utero hypoxia. Chronic hyp...
Development of a salivary gland Sjögren's syndrome tissue chip platform
Abstract The goal of this R21 project is to develop an in vitro salivary gland Sjögren’s syndrome (SS) tissue chip (SSTC) platform based on microbubble array technology using the M...
Developing Interventions for Protecting HIV-Exposed Uninfected Infants against Severe Infections
PROJECT SUMMARY Developing Interventions for The Protection of HIV-Exposed Uninfected Infants against Severe Infections HIV-exposed uninfected infants (HEU) have increased risk of...
B Cell Bioinformatic Supplement: HIV Vaccine Trials Network (HVTN)
Project Abstract Project Title: B-Cell Bioinformatics and Analytics for the HVTN Discovery Medicine Program This proposal outlines the scientific agenda for the HIV Vaccine Trials...
Transcriptional Outputs of the Necroptotic Pathway
Project Summary/Abstract “Necroptosis” is a form of cell death with roles in host defense, autoimmunity, and cancer. Necroptosis is associated with inflammation and immunity, but h...
The impact of targeting CD40-CD154 pathway in nonhuman primate vascularized composite allograft model
Abstract Vascular composite allotransplantation (VCA) is the most immediately available therapy for individuals who have suffered irreparable tissue damages or deformities. While t...
Role of the CD43 Receptor on Effector CD8+ T Cells During Acute Allograft Rejection
PROJECT SUMMARY Despite excellent short-term outcomes after transplantation, the long-term survival of transplanted organs has stagnated for several decades. Recent clinical studie...
Thermostable measles fusion glycoprotein as a new vaccine strategy
Measles (MeV) causes disease worldwide despite efforts towards eradication by vaccine, primarily because it is readily spread between people. Acute MeV infection causes immune amne...
The Role of Coxiella Effector Proteins in Infection and Disease
Coxiella burnetii is an intracellular pathogen that causes the human disease Q-fever. This project is focused on the novel mechanisms Coxiella has evolved to manipulate the host ce...
Project 2 Hollow Fiber Project
Project Abstract/Summary Project #2 The CDC categorize carbapenem-resistant Acinetobacter baumannii (CRAB) and Klebsiella pneumonia (CRKP) as “urgent threats” because few antibioti...
Building and prospective validation of promising mono- and combination regimens that optimize killing of CRAB and CR-Klebsiella pneumoniae and for resistance suppression in murine pneumonia models
Project Abstract/Summary Project #3 The incidence of serious infections, including pneumonia, by carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Klebsi...
Efficient red-to-NIR photo-uncaging and applications in therapy
PROJECT SUMMARY Many light-responsive systems have been produced via natural evolution, including opsins, and phytochromes, while chemists have added to the list of light-responsiv...
A clinician-in-the-loop smart environment to support management of chronic health conditions
PROJECT SUMMARY / ABSTRACT As the population of individuals 65+ grows, so too will the number of individuals who struggle to manage chronic health conditions. Exacerbations, or sud...
ExpLoiting thErapeutic VulnerAbilities in hepaTocEllular carcinoma (ELEVATE)
OVERALL: SUMMARY Hepatocellular carcinoma (HCC), the primary malignancy of hepatocytes, is a diagnosis with bleak outcomes. With the alarming rise in global obesity incidence, obes...
Administrative Core
CORE 1 – ADMINISTRATIVE CORE: SUMMARY The overall goal of this P01 program project grant (PPG) application, titled ELEVATE, is to evaluate novel therapeutic approaches for hepatoce...
Bile Acid-Mediated Signaling In HCC
PROJECT 1: SUMMARY Hepatocellular cancer (HCC) is a rising cause of cancer-related mortality. Nonalcoholic fatty liver disease (NAFLD), especially its aggressive form, nonalcoholic...
Cooperation of Co-Amplified Genes in Hepatocellular Carcinoma
PROJECT 2: SUMMARY Hepatocellular carcinoma (HCC) is a highly fatal disease with an alarming increase in incidence and mortality. Obesity-induced non-alcoholic steatohepatitis (NAS...
A Novel Target in The Tumor Myeloid Compartment for Hepatocellular Carcinoma
PROJECT 3: SUMMARY Given the limited clinical benefits of the current treatments for hepatocellular carcinoma (HCC), there is an urgent need for novel approaches to improve patient...
Designer Cytokine Therapy of Hepatocellular Carcinoma
PROJECT 4: SUMMARY Innovative therapeutic strategies are warranted to treat hepatocellular carcinoma (HCC), which is one of the most common malignancies worldwide with current appr...