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99,167 grants found
Showing 321 – 340 of 99,167 grants
Leveraging Alcohol Use Disorder Screening for Treatment in Routine Perioperative Care: AllUsCare
Abstract Alcohol consumption adversely affects up to 28% of hospitalized patients and contributes to a loss of 133 million disability-adjusted life years and 5.3% of worldwide deat...
Mechanistic and Translational Investigations of HSPB8-associated dominant rimmed vacuolar myopathy
Mechanistic and Translational Investigations of HSPB8-associated dominant rimmed vacuolar myopathy. Autosomal dominant mutations in the heat shock protein family B member 8 (HSPB8)...
Mg-based therapy for mitigating HAND and neuropsychiatric symptoms in the condition of chronic HIV infection
Abstract Microglia (Mg), the brain residential macrophage, play critical roles in maintaining adult brain homeostasis. Mg can function as multi-players such as housekeepers, guards...
Skeletal stem cell plasticity in craniofacial bone diseases.
Project Summary / Abstract Bones in the craniofacial complex are susceptible to various disease conditions due to sustained functional demand associated with essential activities f...
Skeletal heterogeneity of bone marrow stress responses.
Abstract: Defining how the bone marrow functions under stress is indispensable to understand hematopoiesis during disease. A major limitation in the field is that most studies (inc...
KLF2 is a novel endoprotective target for DKD
Summary Patients with diabetic kidney disease (DKD) frequently develop cardiovascular disease (CVD), and vascular complications and endothelial cell injury is a common pathological...
Exploring the function of bacterial condensates in adaptation and evolution
Project Summary Physical organization of biomolecules within the cell is critical for controlling key life processes in health and disease. It has recently been realized that in ad...
Deciphering Novel Principles of Rapid Proteostatic Control and Innovating Spatiotemporal Lysosomal Tools
PROJECT ABSTRACT Proteome integrity is maintained by a complex network that regulates protein synthesis, folding, transport, and degradation. Lysosomes are the catabolic center of...
Longitudinal Oral Microbiome for HIV/HEU/HUU Children Aged 3-4 in Western Kenya
ABSTRACT As of 2022, HIV infection and HIV-related diseases remain among the leading causes of death for children under five, despite the availability of antiretroviral therapy (AR...
Computational methods for characterizing sources of variability in drug response
Project Summary/Abstract Drugs are approved by regulators because they are relatively safe and effective. However, there are typically unanswered basic science questions about the d...
Randomized Clinical Trial of a Culturally-Tailored Suite of Smoking Cessation Resources for American Indian Persons
While American Indian (AI) persons have historically used wild or homegrown tobacco for spiritual purposes, the use of commercially produced tobacco has risen dramatically. Today,...
Understanding Mechanisms of Organic Reactions and Processes through Imaging
Project Summary A mechanistic understanding of reactivity has enabled the development of nearly all modern synthetic organic chemistry, which has in turn revolutionized the discove...
Lysosomal Regeneration (LysoGen) and Rescue as a Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
ABSTRACT This proposal describes a novel concept for acidification of the lysosome and, subsequently, restoration of au- tophagic flux. Autophagy, the intracellular process by whic...
Investigating fundamental signal transduction mechanisms impacted by FOXO transcription factors on NOTCH and JAK/STAT Pathways in stem cell contexts
ABSTRACT We propose a high impact collaborative project to overcome barriers to understanding the roles and regulation of Forkhead box subfamily O transcription factors FOXO -1, -3...
Community Health Information Education Forum (CHIEF)
PROJECT SUMMARY False information can fuel distrust, hinder health literacy, and negatively impact public health responses, as demonstrated during the pandemic. Yet health misinfor...
Synthetic System for Neuron Subtype- and Context-Specific Subcellular RNA/Protein Manipulation and Bioactive Delivery
We propose to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. This system ha...
Delineating the interplay between nucleic-acid-dependent phase separation and immune responses against cGAS in SLE
Project Summary: This work is proposed in response to NOT-AR-23-006 as a mechanistic study of innate and adaptive immune responses in systemic lupus erythematosus (SLE). SLE is a s...
Investigating the microbial basis of early childhood caries via integrative analysis of metagenomics metatranscriptomics and metabolomics
The increasing availability and scale of omics data have revolutionized our ability to understand complex biological processes underlying health and disease. Such biologically info...
Revealing the complexity of dis-inhibitory circuitries
PROJECT SUMMARY Salient signals, like aversive stimulation and reward, should be faithfully detected, and processed by the nervous system to generate an adaptive action. One of the...
OLD family nuclease function across diverse anti-phage defense systems
Project Summary/Abstract Bacteria and the viruses that infect them, termed bacteriophages or simply phages, are locked in a never-ending evolutionary battle. To protect themselves...