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99,167 grants found
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Development of a Direct Diagnostic Test for Infectious and Congenital Syphilis
PROJECT SUMMARY Current diagnostic tests for syphilis are non-optimal, in that they cannot differentiate active from past infection, cannot diagnose congenital syphilis, and have l...
Molecular mechanisms underlying sub-thalamic influences on extinction learning
PROJECT SUMMARY. The expression of debilitating fear toward stimuli previously associated with trauma even after they no longer pose a threat is a core pathology of Post-Traumatic...
Defining Sjögren’s pathogenesis by endotype: maladaptive responses of endogenous salivary gland mesenchymal stromal cells
Sjögren's disease (SjD), a common systemic autoimmune disease characterized by severe oral and ocular dryness and multi-organ involvement, has no disease modifying treatment a...
Transitional Care for Skilled Nursing Facility Patients with Alzheimer’s Disease and Related Dementias and their Caregivers: a Cluster Randomized Trial.
Project Summary/Abstract Every year 400,000 people with Alzheimer’s disease and related dementias (ADRD) are hospitalized, transfer to a skilled nursing facility (SNF), and transit...
Narrowing the mechanistic gap for anterior prefrontal cortex function
PROJECT SUMMARY Prefrontal cortex (PFC) is a large and heterogeneous brain area comprising the front third of the human brain that has been implicated in numerous mental health dis...
Blood Trauma, Vascular Remodeling, and Vasoregulation with Total Body Continuous Versus Pulsatile Artificial Circulation
Project Abstract Left ventricular assist device support is standard therapy for patients with advanced, life-threatening heart failure. However, current-generation impeller-based b...
Investigation of Cardiac Arrhythmias in TANGO2 Disorder
ABSTRACT TANGO2 Deficiency Disorder is an autosomal recessive disease caused by genetic alterations in TANGO2 (Transport and Golgi Organization Homolog 2). Patients, primarily youn...
Long-term effects of universal health insurance in developing countries: Evidence from Mexico
Project Title Long-term effects of universal health insurance in developing countries: Evidence from Mexico Project Summary/Abstract (30 lines of text) The implementation of govern...
Identifying placental tissue tropism and cellular mechanisms of Ebola Virus transmission from mother to fetus in pregnancy
Project Abstract Maternal viral infections during pregnancy may result in catastrophic outcomes for her health as well as for her developing fetus. Recent emerging virus epidemics...
A total school approach using safeguarding to address HIV-related stigma and discrimination in boarding schools in Zambia
PROJECT SUMMARY HIV-related stigma and discrimination operate at multiple socioecological levels and are known obstacles to optimal health and HIV outcomes. In Zambia, some boardin...
Adaptation and evaluation of an intersectional stigma reduction intervention to increase HIV care engagement among women who use drugs
PROJECT SUMMARY The goal of this R01 proposal is to adapt and pilot an intervention to reduce individual-level intersectional HIV/AIDS and drug use stigma and increase retention in...
Kabawil: Adapting an Intervention to Reduce Intersectional Stigmas among Indigenous Sexual Minority Men and Traditional Healers in Mesoamerica
SUMMARY/ABSTRACT During the past decade in Latin America, new yearly HIV infections rose 21%, and as of 2022, HIV infections were still rising. Of the 3.8 million people living wit...
Cluster Randomized controlled trial of Using PrEP, Doing it for Ourselves [UPDOs] Protective Styles: A salon-based intervention to improve PrEP uptake among Black cis-gender women.
HIV disproportionately affects Black cisgender women living in the United States south threatening progress toward the Ending the HIV Endemic initiative's 2030 goals. Although...
Modeling non-additive genetic mechanisms for complex traits
Project Summary A central question in the genetics of complex traits is understanding how variation in DNA sequences leads to variation in phenotype. Recent technological advances...
Adolescent brain maturation and psychopathology
Healthy adolescent brain maturation involves several highly coordinated processes including extensive and dynamic reorganization of structural and functional networks and neuropil...
An Ancient Neural Enhancer that has Rapidly Evolved in the Human Lineage
The distinctive features of humanity—our intelligence, creativity, language, as well as our ecological and demographic success—are thought to be the result of evolutionary changes...
Collaborative to understand impacts of early preventive interventions on suicide and overdose mortality using data harmonization methodology
Project Summary The goal of this application, submitted in response to RFA-MH-23-275, “Using Secondary Data Analysis to Determine Whether Preventive Interventions Implemented Earli...
Demographic and Health Effects of Climate Exposures Across the Life Course
PROJECT SUMMARY This project will measure how exposures to climatic variability (i.e., temperature and precipitation anomalies) during early-life and adolescence affect the fertili...
Improving Shared Decision Making in Early use of Neurotechnologies Across Different Disease Stages
ABSTRACT Recent research emphasizes the opportunities of using neurotechnology earlier in the disease progression. However,earlier use of neurotechnology also raises significant et...
Large-scale integrated data analysis of lymphocyte receptor repertoires with workflows
Project Summary / Abstract Over the last decade, high-throughput B cell and T cell receptor repertoire sequencing has become a fundamental method for investigating adaptive immune...