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99,167 grants found
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Synergizing neutralization and non-neutralization antibody targets at the HIV/SIV viral spike apex
Project Summary An HIV vaccine remains a critical and as yet unrealized asset in the 40-year fight against the HIV/AIDS pandemic. New insights towards achieving vaccine protection...
Sequential Strategies to Reach and Reengage Individuals after Lapses from HIV Care in Zambia
ABSTRACT Treatment lapses remain one of the most enduring challenges to viral suppression in Africa. These individuals have higher rates of viremia (~70%), morbidity, and mortality...
miRNA profiling for monitoring and adjustment of immunosuppression in liver transplant recipients
Abstract Immunosuppression management follows standard protocol that is aimed at predetermined drug levels, with minimal adjustments over the lifetime of the recipient. While succe...
Spore germination pathway in Clostridioides difficile and its pharmacological intervention
ABSTRACT Clostridioides difficile is an anaerobic Gram-positive bacterium that colonizes the gut of patients treated with broad-spectrum antibiotics. A challenge in treating C. dif...
Immigration Policies, Dietary Acculturation, and Childhood Obesity.
PROJECT SUMMARY One in four children in the United States (US) has at least one immigrant parent—more than a third of whom came to the US from Mexico more than any other country of...
Identification of predictive biomarkers for severe acute leptospirosis and its long-term sequelae
Leptospirosis is a potentially life-threatening zoonosis with protean manifestations and a leading cause of acute febrile illness (AFI) in the tropics. The acute phase of leptospir...
Development of a hamster model for hepatitis B virus infection
PROJECT SUMMARY Hepatitis B virus (HBV) has infected more than one-third of the world’s population and that almost 296 million people are currently living with chronic infection in...
Washington University ACCERT center
Project Summary (Abstract) Goal: The overall goal of the WashU ACCERT is to advance cancer control equity through community - engaged multilevel research interventions that address...
Administrative Core
PROJECT SUMMARY – ADMINISTRATIVE CORE The Administrative Core will provide the structure for effective and efficient operation and maintenance of the Washington University Advancin...
Research Measures, Methods and Data Management Core
Project Summary- Research Methods, Measures, and Data Management Core The Research Methods, Measures, and Data Management (RMMDM) Core will advance the goal of the WashU-ACCERT cen...
Social Determinants of Health Research Project
Project Summary- Social Determinants of Health Multilevel Intervention Financial toxicity –hardships caused by the costs of cancer treatment– are common and have substantial impact...
Community Responsive Research Program
The overall goal of WashU-ACCERT is to advance cancer control equity through community-engaged multi- level research that addresses the impact of social determinants of health on c...
Neonatal, Lactation, and Child Health Outcomes Following RSV Vaccination During Pregnancy
PROJECT SUMMARY Respiratory Syncytial Virus (RSV) can cause severe illness in young children and is the leading cause of infant hospitalization in the United States. Prenatal RSV p...
Defining multifunctional roles for proteins in development and disease
Project Summary This proposal for the NIGMS R35 Early-Stage Investigator award seeks to support my laboratory’s overall mission of determining multifunctional roles for proteins in...
Identifying, Validating, and Characterizing Biological Subtypes of PsychiatricDisorders Using a Novel Computational Framework
PROJECT SUMMARY Biologically-grounded data-driven stratification of disease has revolutionized most of modern medicine. Yet, psychiatric disorders—a major public health concern—are...
Active HCV diagnosis to support prevention of HCC in LMICs
Project Summary HCV is a major threat worldwide, infecting over 58 million people and causing 300,000 deaths from HCV-related cirrhosis or hepatocellular carcinoma (HCC) each year....
Regulation of Androgen Receptor by NXTAR Long non-coding RNA in Prostate Cancer and its Therapeutic Implications
Abstract Androgen receptor (AR) signaling continues to play a dominant role in all stages of prostate cancer (PC), including castration-resistant prostate cancers (CRPCs) that have...
Role of LAM-specific TREM1 in leukemogenesis
PROJECT SUMMARY/ABSTRACT Cancer progression is heavily influenced by supportive cells in the tumor microenvironment. Macrophages, an important component of tissue microenvironment,...
Neural Mechanisms of Anticholinergic Burden in Mid- to Late-Life Schizophrenia Spectrum Illness
PROJECT SUMMARY Schizophrenia spectrum disorders (SSD) are associated with significant morbidity and mortality across the world. A considerable portion of healthcare and societal c...
The role of vascular failure and biomechanical stress in the development, progression and healing of osteochondritis dissecans lesions
PROJECT SUMMARY/ABSTRACT Ostechondritis dissecans (OCD) is a developmental orthopaedic disease affecting children and young adults. It is characterized by formation of osteochondra...