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99,167 grants found
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A mechanistic approach to intercalated cell phagocytosis
PROJECT SUMMARY/ABSTRACT Pyelonephritis continues to result in considerable morbidity, mortality, and health care expense. To develop new treatment strategies, a more thorough unde...
Mental Health Risk and Resilience among Latinx SGM Adolescents and their Parents
Project Summary/Abstract This application is in response to NOT-OD-23-166, PAR-21-358, and aligns with NIMHD's key areas of interest including family health and well-being for...
Pax8-Hnf4a co-regulation in ischemic kidney injury
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.The goals of this project are to 1) test the hyp...
The role of the N-terminus of GATA1 in erythropoiesis
PROJECT SUMMARY The zinc finger transcription factor GATA1 is essential for development of a subset of hematopoietic lineages, including erythroid cells and megakaryocytes. Inherit...
Effect of hippocampal feedback projections on the function of the early olfactory system
Project Summary/Abstract The neural circuits associated with encoding odors in patterns of activity throughout the brain are critical not only for chemosensory perception, but are...
STrengthening Research OpportuNities for Growth at Meharry Medical College (Meharry-STRONG)
Project Summary/ Abstract The goal of the STrengthening Research OpportuNities for Growth at Meharry Medical College (Meharry- STRONG) Program is to assess research capacity and de...
Linking Exercise for Advancing Daily Stress (LEADS) Management and Resilience in Black Families
Project Summary/Abstract Chronic stressors, such as racial discrimination, have wide-reaching harmful effects on the physical, social, and psychological well-being of many African...
Investigating the role of Lipocalin Prostaglandin D2 Synthase and its metabolite PGD2 in non-alcoholic fatty liver disease
PROJECT SUMMARY/ABSTRACT Despite non-alcoholic fatty liver disease (NAFLD) being the most common chronic liver disease worldwide, molecular mechanisms contributing to its etiology...
Development of novel approaches for gene editing therapies of cystic fibrosis
SUMMARY Chronic lung infection is the primary cause of death in patients with cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regul...
Tau Mediates Microtubule and Mitochondrial Dynamics to Control Cellular Organization and Alveolar Epithelial Repair
SUMMARY Alveolar tissues must maintain proper cellular organization to perform vital functions such as gas- exchange at homeostasis and during repair. In human lungs, type-1 alveol...
Rapid Diagnosis and Treatment Response Phenotyping of Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis
PROJECT SUMMARY Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer care; however, ICIs can lead to off-target immune-related adverse events (irAEs) such as ICI-ind...
Bridging the Treatment Gap by Expanding Access to Care for People with Epilepsy in Kenya (BEACON)
PROJECT SUMMARY/ ABSTRACT Epilepsy is responsible for about 1% of the global burden of disease, with the highest disease-related burden found in sub-Saharan Africa. The majority of...
Radiation Guided Ablation for Ventricular Tachycardia
Ventricular tachycardia can be a life-threatening arrhythmia that requires effective and timely treatment. This treatment often takes the form of catheter based ablation; however,...
The role of phosphorylation in the cellular organization of the proteome
PROJECT SUMMARY Protein phosphorylation is the most important and most extensively studied mechanism by which cells rapidly sense signals, transduce signals, and execute decisions....
Molecular mechanism of eukaryotic chromosome replication
Summary DNA replication stress is a major source for genome instability associated with numerous diseases, including cancer. Therefore, understanding the molecular basis of replica...
Analytical characterization and validation of blood-biomarkers for monitoring TBI evolution
Abstract Consistent with the overall mission of NINDS for the PAR-21-056 Announcement, Analytical Validation of a Candidate Biomarker for Neurological Disease, we have assembled a...
Effects of wildfire smoke on respiratory antiviral defense responses
PROJECT SUMMARY Wildfire smoke increasingly contributes to ambient air pollution and more specifically PM2.5 and has been associated with increased respiratory virus morbidity and...
The role of Tie2 signaling in Aortic Valve Remodeling
Abnormal valve development contributes to many common congenital heart malformations. Developmental signaling events that regulate early valve formation have been studied extensive...
Advancing novel therapeutics and translational science to close the survivorship gap in pediatric, adolescent and young adult (AYA) lymphoma
PROJECT SUMMARY/ABSTRACT: Hodgkin Lymphoma (HL) has its first incidence peak in the adolescent and young adults (AYA) years. Despite the success of chemotherapy and radiation in yo...
Natural Phenolic Compounds against Oral Candidiasis (OC)
Contact PD/PI: MYLONAKIS, ELEFTHERIOS PROJECT SUMMARY Despite the availability of anti-retroviral therapy, oral candidiasis caused by the overgrowth of Candida spp. is the most fre...