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99,167 grants found
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Effects of enriched parent-infant interaction on health in early life
PROJECT SUMMARY Early life experiences, such as those associated with stable attachment, supportive relationships, and nurturing environments, have profound effects on lifelong phy...
Repurposing Ferumoxytol Nanoparticles to Promote Orofacial Stem Cell Function for Autotherapies
Project Description The advancement of regenerative medicine has provided many new potential treatments for craniofacial bone defects, in which mesenchymal stem/progenitor cells (M...
Ketone supplementation as an intervention to alleviate alcohol withdrawal and improve brain energetics in Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Alcohol Use Disorder (AUD) is a chronic, relapsing brain disorder that accounts for 5% of deaths globally. There is an urgent need to test interventions th...
Integrative Analysis and Visualization Platform for Cancer Regulatory Genomics
PROJECT SUMMARY Recent advancements in next-generation sequencing technologies have resulted in the generation of vast quantities of publicly accessible data that are specific to c...
Exploring the function of novel arginine phosphorylation in streptococcal physiology
ABSTRACT Post-translational modification (PTM) by phosphorylation plays an important role in protein folding, stability, and function. In bacteria, protein phosphorylation plays a...
CD8+ T CELL REPROGRAMMING TO BOOST ANTIVIRAL POTENTIAL AGAINST CHRONIC INFECTION
PROJECT SUMMARY/ABSTRACT There is substantial evidence that stem-like CD8+ T cells have a central role in the natural control of chronic viral infection. For example, virus-specifi...
State social policy interventions for maternal health
Project Summary Poverty is the most widely studied fundamental determinant of maternal mental health, morbidity, mortality, and inequities in the U.S. and worldwide. Low absolute a...
Modulating growth, progression and metastasis in breast cancer by inhibiting MDA-9
Despite therapeutic advances, the 5-year survival rate from metastatic triple negative breast cancer (TNBC) has not improved significantly for 30-years. As such, significant benefi...
Brainstem glial senescence and dysfunction in obesity-induced hypertension
Elevated sympathetic nerve activity (SNA) mediates the increased risk for hypertension and heart failure in obesity. Yet the mechanisms that contribute to obesity-induced increases...
Development and Psychometric Evaluation of Gastrointestinal Symptom Measures in Autistic Children and Adults
PROJECT SUMMARY/ABSTRACT Gastrointestinal (GI) symptoms appear to be common and disabling in children and adults on the autism spectrum. Co-occurring GI symptoms are associated wit...
Investigating Novel HIV Reservoirs in the Pulmonary Vasculature
PROJECT SUMMARY Infections with Human Immunodeficiency Virus (HIV) remain a major global public health concern. The HIV reservoirs are a leading reason for which HIV infection rema...
Generation of highly differentiated NK cells to synergize with broadly neutralizing antibodies to establish viral control in absence of ART
ABSTRACT/SUMMARY A distinguishing feature of SIV infection in African green monkeys (AGMs), a natural host species for SIV, is the absence of viral dissemination in the lymphoid B-...
Exploring sustained implementation and fidelity of an evidence-based HIV prevention program
The importance of – and difficulty in – sustaining implementation, with fidelity, of effective HIV interventions is well recognized. Our research partnership of >20-years in The...
Identifying multilevel facilitators of care outcomes among Positive Deviants to design an intervention for Black sexual minority men living with HIV
Project Summary/Abstract The goal of this R01 is to build upon our sponsored Positive Deviance research by identifying how durably virally suppressed Black sexual minority men livi...
Implementing Sustainable mobile health Technology to Optimize smoking cessation Program for Lao people with HIV (I-STOP)
PROJECT SUMMARY: Tobacco use remains the leading modifiable risk factor for preventing cancer globally, particularly among people with HIV (PWH). In Lao People's Democratic Re...
Linking insufficient sleep with body weight in Black emerging adults.
PROJECT ABSTRACT Compared to peers in other racial groups, Black emerging adults (18-28-years old) have the highest risks of short sleep duration and cardiovascular disease. This i...
Stem-like T cells as bioindicators and orchestrators of the disease process in MS and animal models
There is an urgent need for a better understanding of the propagation of encephalitogenic autoimmune responses and the identification of relevant immune cells and their specific ch...
Investigating the Role of Macrophages in Heart Failure with Preserved Ejection Fraction
CHALLENGE: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome that presents with heart failure symptoms, unaltered left ventricular ejection frac...
Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy
SUMMARY Dilated cardiomyopathy (DCM) associated heart failure is a leading cause of death and new therapeutic strategies are needed. Pathogenic variants in over 50 genes contribute...
Structural consequences of PKC-dependent phosphorylation of Kv7.2
Project Summary M channels are critical for regulating the excitability of neurons. Dysfunction of M channel activity can cause epilepsy. While M channels have been intensely studi...