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99,167 grants found
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Project 1: Vaccine Design Neurotropic Flaviviruses
SUMMARY Emerging and re-emerging arthropod-vectored viruses pose a significant threat to human health. Tick- and mosquito-transmitted viruses can cause encephalitis and hemorrhagic...
Project 2: Vaccine Design Epidemic Flaviviruses
SUMMARY Arthropod vector-borne flaviviruses threaten the health of people in nearly all countries of the world. Over the past 30-years, the epidemiology of flaviviruses has been ch...
Project 3: Vaccine Design [mRNA] VEEV/CHIKV (alphaviruses)
SUMMARY Alphaviruses are mosquito-transmitted viruses that cause severe disease in humans. The genus is divided into two groups: Arthritogenic viruses cause arthralgia and musculos...
Project 4: Vaccine Design [insect alphavirus chimera] VEEV/CHIKV (alphaviruses)
SUMMARY, Project 4 Alphaviruses regularly threaten global health, including long-established emerging viruses like Venezuelan equine encephalitis virus (VEEV, the most important of...
Project 5: mAb Development Flaviviruses and Alphaviruses
SUMMARY Flaviviruses and alphaviruses are insect-transmitted RNA viruses that globally cause severe human syndromes, including acute and chronic musculoskeletal disease, hemorrhagi...
IMPACT-MH: Clinical and behavioral fingerprints of psychopathology
SUMMARY Psychiatric symptoms are a leading cause of suffering and disability worldwide. Decades of research have focused on understanding their etiology and underpinnings, typicall...
Structural and Functional Studies on the Glucosyltransferases of the Dental Caries Pathogen Streptococcus mutans
SUMMARY Dental caries is a polymicrobial disease that affects much of the human population worldwide, where the equilibrium of a cooperative eco-organization among commensal microb...
Determining the role of AnnexinA2 in HIV-1 and SARS-CoV-2 assembly
Human Immunodeficiency Virus Type 1 (HIV-1) and Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) are two enveloped RNA viruses that affect significant proportions...
Genetic Causes of Endocrine Hypertension in Black Americans
PROJECT SUMMARY/ABSTRACT Primary aldosteronism (PA) is not only the most common adrenal disorder but also the most common cause of endocrine hypertension. PA is characterized by re...
Modeling of cell-specific LRP1 signaling in acute myocardial infarction
SUMMARY Modeling cell-specific LRP1 signaling in acute myocardial infarction Improving the treatment of acute myocardial infarction (AMI) to prevent heart failure (HF) and death re...
School-Located Vaccination to Reduce Inequities in Vaccination Uptake Among Historically Excluded Populations in Colorado
Health disparity populations are more likely to face barriers to immunization in traditional medical settings. Specifically, people from minoritized racial/ethnic groups, residents...
Identifying and overcoming mechanisms of resistance to effectively target the TBL1/β-catenin signaling axis for high-risk osteosarcoma
Osteosarcoma (OS) is the most common bone malignancy in the pediatric population. Overall survival rates remain about 65-75% and are significantly worse for patients with metastati...
Addressing tumor heterogeneity in pediatric gliomas with precision adoptive T cell therapy
Project Summary Tumor-specific immunotherapy is a promising modality capable of improving clinical outcomes for children affected with high-grade glioma (HGG). We have pioneered a...
Decoding the glycome of oral Treponema denticola
PROJECT SUMMARY The bacterium Treponema denticola (Td) is an important and yet understudied oral pathobiont that is highly associated with periodontitis, necrotic root canals, and...
mRNA lipid nanoparticles for pre-eclampsia
PROJECT SUMMARY Pre-eclampsia is an obstetric condition that affects 5–8% of all pregnancies and is a leading cause of maternal mortality worldwide. Pre-eclampsia is characterized...
Developing liquid biopsy tests for malignant effusions using artificial intelligence-assisted, morphology-based isolation of tumor cells
PROJECT SUMMARY/ABSTRACT Background. Malignant effusions (ME) are frequent complications of metastatic breast cancer (MBC) associated with severe symptoms and dire prognosis. Treat...
Evolution of heat tolerance and drug resistance in Cryptococcus
Project Summary Environmental microbes are affected by and evolve to succeed in the changing environments they inhabit. As a result, changes in the environment can select for micro...
Harnessing PRX1 expressing cells for endogenous periodontal regeneration
Periodontal disease (PD) is the sixth most prevalent health condition in the World. It leads to periodontal tissue loss, tooth loss, and is linked to other high prevalence diseases...
Multi-functional 3D Printed Dental Implants for Preventing Peri-implantitis
Project Summary/Abstract Peri-implantitis is one of the most common and challenging implant-related oral infections that affect millions of patients every year. This project aims t...
Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage Cocktails
ABSTRACT: With only one mechanistically novel antibiotic developed in the past decade with activity versus resistant Gram-negatives, extensively-drug resistant Pseudomonas aerugino...