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99,167 grants found
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3D In vivo dosimetry for FLASH proton therapy
ABSTRACT: This U01 application aims to (1) develop a robust protoacoustic dosimeter for 3D in vivo dosimetry in proton FLASH therapy, which is essential for its clinical applicatio...
Nonlinearities in Human Vestibular Reflexes
Project Summary/Abstract The long-term goal of our research program is to assess the natural disease state of age-related changes in the vestibular system and improve clinical diag...
CD79A as a molecular switch regulating B cell activation
B lymphocytes are critical players in the development of protective immunity, as well as in pathological states such as autoimmunity. Careful regulation of the strength and quality...
Machine learning-enabled design of prototype pathogen vaccines and antibodies
PROJECT SUMMARY – OVERALL: MACHINE LEARNING-ENABLED DESIGN OF PROTOTYPE PATHOGEN VACCINES AND ANTIBODIES We propose a highly synergistic Center focused on developing end-to-end str...
Core A: Administrative
PROJECT SUMMARY – CORE A: ADMINISTRATIVE The Administrative Core will coordinate the scientific, administrative, and financial functions of our multi-project, multi-institution Cen...
Core B: Data Management
PROJECT SUMMARY – CORE B: DATA MANAGEMENT The Data Management Core will create, operate, and maintain state-of-the-art computer systems to store and safeguard the diverse types of...
Core C: Vaccine production and process development
PROJECT SUMMARY – CORE C: VACCINE PRODUCTION AND PROCESS DEVELOPMENT The Vaccine Production and Process Development Core will provide both high-throughput and scalable biologics pr...
Core D: Animal models and vaccine evaluation
PROJECT SUMMARY – CORE D: ANIMAL MODELS AND VACCINE EVALUATION Among viruses that cause disease in humans viral zoonoses within the family Paramyxoviridae and order Bunyavirales co...
Core E: Phylogenetic and mutational scanning
PROJECT SUMMARY – CORE E: PHYLOGENETIC AND MUTATIONAL SCANNING This Core will use cutting-edge experimental and computational techniques to ensure that the vaccines target the full...
Project 1: Computational methods
PROJECT SUMMARY – PROJECT 1: COMPUTATIONAL METHODS Project 1 will develop the general computational methods that underpin our Center’s approaches to vaccine and antibody design. In...
Project 2: Viral entry, antibodies, and structural biology
PROJECT SUMMARY – PROJECT 2: VIRAL ENTRY, ANTIBODIES, AND STRUCTURAL BIOLOGY Studies of viral glycoproteins and their interactions with receptors and antibodies are paramount to va...
Project 3: Antigen design
PROJECT SUMMARY – PROJECT 3: ANTIGEN DESIGN Project 3 focuses on developing generalizable approaches to the modeling, design, and evaluation of native-like antigens for arenaviruse...
Project 4: Protein nanoparticle vaccines
PROJECT SUMMARY – PROJECT 4: PROTEIN NANOPARTICLE VACCINES Project 4 focuses on developing generalizable approaches to the design, production, and evaluation of two-component prote...
Project 5: mRNA and mRNA-launched nanoparticle vaccines
PROJECT SUMMARY – PROJECT 5: mRNA AND mRNA-LAUNCHED NANOPARTICLE VACCINES The goal of Project 5 is to develop generalizable approaches and platforms to design, make, and evaluate m...
Flavivirus and Alphavirus ReVAMPP (FLARE)
SUMMARY. The Flavivirus and Alphavirus ReVAMPP (FLARE) Center will develop and optimize protein nanoparticle, virion-based, and mRNA vaccine platforms, and monoclonal antibody (mAb...
Core A: Administrative
Core A (Administrative Core) Summary The Administrative Core A (hereafter, Core A) will serve as the central entity to direct, oversee, and ensure the mission of the Flavivirus and...
Core B: Data Management
Summary, Data Mangement Core B The Data Management Core B (hereafter, Core B) will be the nexus for all data management, analysis, and harmonization activities in the Flavivirus an...
Core C: Structure, Computational, Protein Engineering
SUMMARY Flaviviruses and alphaviruses are enveloped, single-stranded RNA viruses that cause epidemics of human disease on a global scale, with new virus members regularly emerging...
Core D: Animal Immunogenicity and Challenge
SUMMARY Flaviviruses and alphaviruses are emerging arthropod-borne viruses that cause severe and often life-threatening disease in humans, and ongoing and recent epidemics have inf...
Core E: Correlates of Protection
Flaviviruses and alphaviruses are enveloped, single-stranded RNA viruses that cause epidemics of human disease on a global scale, with new family members regularly emerging and cau...