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Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosage
Project Summary Severe combined immunodeficiency (SCID) is a group of genetic disorders that abrogate T cell development and function. Allogeneic hematopoietic cell transplantation...
A Mixed Methods Analysis of Pediatric Voice Therapy
Voice disorders occur in 6–17% of children, resulting in dysphonia (i.e., altered vocal quality), which has significant negative health, social, emotional, and educational conseque...
Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche
OVERALL: ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is an aggressiveand clinically heterogeneous malignancy derived from B-cells transiting the germinal center (GC) reaction. I...
Admin Core
CORE A: ADMINISTRATIVE CORE: PROJECT SUMMARY/ABSTRACT The responsibilities of the Administrative Core include monitoring and planning of scientific activities, providing scientific...
Project 1 Melnick
PROJECT 1: ABSTRACT One of the critical unmet needs from both the scientific and therapeutic standpoints in the B-cell lymphoma field is understanding how these tumors evade the no...
Project 2 Josefowicz
PROJECT 2: SUMMARY/ABSTRACT Activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) and Epstein Barr virus associated viral lymphomas (EBV+ lymphoma) have in common that th...
Project 3 Cerchietti
PROJECT 3: SUMMARY/ABSTRACT This project focus in the biology of diffuse large B-cell lymphoma (DLBCL) in older individuals (i.e., patients 75-years or older). Based on findings in...
Project 4 Green-Davis
PROJECT 4: ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most common form lymphoma and is conventionally treated with a combination of chemotherapeutics with the anti-CD20...
Experimental Study of a Model to Support Research Evidence Use for Protecting Children
Project Summary Protecting children through the primary prevention of child abuse and neglect (CAN) is a major priority given that an estimated 1 in 7 children are affected each ye...
Spatial and Temporal Resolution of EosinophilSpecialization in Allergic Microenvironments
ABSTRACT Eosinophilic inflammation is a key feature of many human pathologies, and therapeutic targeting of eosinophils is of clinical interest, as illustrated by the new class of...
Investigating the oral microbiome in hematopoietic cell transplants
ABSTRACT While hematopoietic cell transplant (HCT) is an effective curative treatment for children with various malignant and non-malignant diseases, it is also associated with sev...
Engaging Mental Health Services for Preschoolers at Risk
PROJECT SUMMARY/ABSTRACT Most mental health (MH) disorders develop in early childhood but are not clinically identified or treated until later—delaying treatment services that coul...
Federal Housing Assistance and Birth Outcomes in the United States
PROJECT SUMMARY Adverse birth outcomes, including prematurity and low birthweight, are a persistent public health problem in the United States. They affect nearly half a million ne...
THRIVE-DM: Improving Diabetes Care with Strategies for Addressing Health-Related Social Needs and Community Partnerships
PROJECT SUMMARY/ABSTRACT We propose to implement and assess THRIVE-DM, an expansion of our existing THRIVE health-related social needs (HRSN) screening and referral program, with t...
A Triad Approach Towards Improved Diagnostics for Maternal and Congenital Syphilis
Project Summary Syphilis is a sexually and vertically transmitted disease caused by Treponema pallidum subspecies pallidum (TPA). While adult syphilis is often asymptomatic and sel...
Effects of maternal exercise on fetal akinesia-impaired bone and joint development
Abstract Mechanical forces exerted by fetal movement during development influence skeletal morphogenesis. Thus, fetal akinesia (insufficient movement), caused by low amniotic fluid...
Elucidating the mechanism of Ga13 mediated tumor suppression in pancreatic cancer
RESEARCH SUMMARY The heterotrimeric G proteins transduce signals from the G protein-coupled receptors (GPCRs), the largest class of cell surface proteins that regulate a wide varie...
Core 1: Lymphoma models
CORE 1 LYMPHOMA MODEL SYSTEMS: SUMMARY/ABSTRACT The Lymphoma Model System core (LMSC) will assemble and characterize the reagents critical for this proposal, including the vast arr...
Biostatistics and Computational Biology (BCB) Core
CORE 2: BIOSTATISTICS AND COMPUTATIONAL BIOLOGY: SUMMARY/ABSTRACT The Biostatistics and Computational Biology (BCB) Core for this P01 will enable cost-effective data processing, an...
Core 3: MPIP.
CORE 3_MULTIPARAMETER IMAGING AND PATHOLOGY: SUMMARY/ABSTRACT One basic function of Core 3 includes the collection and distribution of specimens and patient samples to P01 investig...