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99,167 grants found
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Maternally acquired immunity in protection against enterotoxigenic E. coli infections in infants
PROJECT SUMMARY Enterotoxigenic E. coli (ETEC) is a leading cause of diarrhea, that continues to be associated with significant morbidity, mortality and stunting, among children
3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP)
Project Summary/Abstract Somatic mutations alter the folding and therewith function of oncogene and tumor suppressor proteins. The alterations in protein structure drive malignant...
Apelin receptor axis and long-term consequences of preeclampsia
Summary Preeclampsia (PE) is a hypertensive disorder of pregnancy that occurs in 5-7% of all pregnancies. Women exposed to PE are more likely to develop cardiovascular and subclini...
Development of Non-invasive Liquid Biopsy Screening Tool for Preterm Birth Causes and Consequences
Program Director/Principal Investigator (Last, First, Middle): Peters, David, G. Abstract The overarching goal of this study is to develop epigenomic liquid biopsy methods for both...
Harnessing CD89+ NK Cells for Novel Therapeutic Interventions Against HIV/SIV
While antiretroviral therapy (ART) can control the replication of human immunodeficiency virus (HIV) and delay disease progression, there is still no cure, and HIV remains a global...
Hormonal Regulation of HSV-1 Replication in Neurons
PROJECT SUMMARY/ABSTRACT HSV–1 infection in neurons remains a mystery. Acute infection in non-neurons is straightforward: the virus completes its entire life cycle in less than 20...
Ontogeny and metabolism of lung alveolar macrophages in tuberculosis
Project Summary/Abstract Our current vaccine development strategies against tuberculosis (TB) focus on the induction of adaptive immune responses, but that may not be sufficient to...
Disrupting Implicit Bias in Dental Clinical Decision-Making and Mitigating Its Effect on the Dentist-Scientist Workforce Pathway
PROJECT SUMMARY Bias is a significant contributor to health disparities and health inequities; and rises to the level of a public health problem. Research has consistently shown th...
Tuning KITv CAR T cells for the solid tumor environment
PROJECT ABSTRACT We developed and translated CD28 costimulated chimeric antigen receptor (M28z CARs) T cells that target mesothelin(MSLN), a cancer-associated antigen that is overe...
Metabolism and cell cycle as mediators of fluid shear stress effects on vascular endothelium in health and disease
Project Summary This project is based on the critical role of fluid shear stress from blood flow acting on the vascular endothelium in determining susceptibility to atherosclerosis...
Harnessing Broad-Specificity Phage Recombinases for Universal Bacterial Editing platforms
PROJECT SUMMARY The vast array of genetic elements within a bacterial genome dictates its potential to cause disease. These elements influence virulence, antibiotic susceptibility,...
Enhancing the Survival of Low Birth Weight Infants in Low Resource Settings using an Implementation Science Approach
PROJECT SUMMARY Globally, about 20 million infants are born with low birthweight (LBW), and these infants face a myriad of health challenges, including difficulties in regulating b...
BREATH - Breastfeeding, Early-life Microbiome and Respiratory Health Study
PROJECT SUMMARY Significance: Childhood respiratory diseases pose a significant health burden and lack primary prevention strategies. With genetics explaining only a fraction of th...
Dissecting a novel tumor-promoting axis in cholangiocarcinoma
There is an urgent need to identify effective treatments for intrahepatic cholangiocarcinoma (CCA), a highly desmoplastic tumor of the bile ducts with a five-year survival rate of...
Encouraging Multiple PrEP Options for Women Engaged in PRimary Care (EMPOWER)
ABSTRACT We will adapt and pilot test a technology-enabled, primary care-based, health literacy strategy to empower women with increased vulnerability to HIV to make informed decis...
Intracellular trafficking of the essential signaling metabolite heme in myeloid cells: impact on physiology and disease
The growth factors and transcriptional activators that give rise to diverse populations of functionally distinct circulating monocytes and tissue-resident macrophages (MFs) have la...
The Role of Food Sensitization in Cardiovascular Disease
PROJECT SUMMARY/ABSTRACT Despite major advances over recent decades, cardiovascular disease (CVD) remains a leading cause of death in the USA and globally and risk for factors that...
Emotional Arousal and its Neurobehavioral Associations during Development
Project Summary Emotional arousal is a key bio-behavioral target for investigations of transdiagnostic mechanisms underlying the development of pathological emotional states (e.g.,...
Leveraging a Strategic Alliance of Community-Based Implementers and Researchers to Characterize, Protocolize, and Scale Up Local Implementation Strategies for Ending the HIV Epidemic among Latino MSM
Abstract. In response to NOT-AI-23-070, we propose to characterize, assess, and protocolize implementation strategies that HIV organizations are using to improve the reach of PrEP...
Translational studies in humans and mice to test a circuit-level computational model of auditory hallucinations..
Auditory hallucinations (AH) are core symptoms of psychosis for which treatment is often ineffective or poorly tolerated. A first step towards developing more selective and safer b...