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99,167 grants found
Showing 3,201 – 3,220 of 99,167 grants
The Bidirectional Gut-Microbiota-Brain Axis in Parkinson’s disease: integrating mechanistic biomarkers of disease severity and progression
ABSTRACT In this UO1 application, the Medical College of Georgia and Rush Gastroenterology & Neurology Research Centers propose prospective cross-sectional and longitudinal stu...
Racial/Ethnic Disparities in Housing Instability, Extended Kin Resources, and Late-Life Health
Project Summary Housing is a critical social determinant of health and key contributor to racial/ethnic health disparities in the US. In the context of rising housing costs, a rece...
Brain Stiffness as a Predictor of Chronic Subdural Hematoma Characteristics and Tissue Reexpansion
PROJECT SUMMARY Chronic subdural hematoma (CSDH) is one of the most common types of intracranial hemorrhage, affecting 3.4-5/100,000 per year in the general population and 60-80/10...
Develop and Validate a Mouse Model for Alzheimer Disease in Down Syndrome
Alzheimer disease (AD) exacts enormous personal and financial burdens in the aging. People with Down syndrome (DS) (i.e., trisomy 21, HSA21) are at markedly increased risk of AD, a...
Epileptic Electrophysiological Brain Networks Modeling with Partially Observable Brain Regions
Project Summary Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide of all ages. Seizures in up to one third of epilepsy patients are d...
Hybrid Effectiveness-Implementation Trial of a School Clinician Training and Psychosocial ADHD/ODD Intervention Program Adapted for Schools across Mexico (CLS-A-FUERTE)
Neurodevelopmental disorders of Attention-Deficit/ Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder (ODD) are extremely common but underserved with Evidence-Based Tr...
Leveraging harmonized data to improve external validity and efficiency of clinical trials for treating opioid use disorder
Randomized clinical trials for the treatment of psychiatric and substance use disorders can be difficult, time- consuming, and expensive to conduct. Partially as a consequence, the...
CiLostAzol for pReventIon of recurrent sTroke in Africa (CLARITY-Africa)
PROJECT SUMMARY Global estimates suggest that sub-Saharan Africa (SSA) now has the highest incidence, prevalence, and worst survival outcomes of stroke. With an estimated 1.4 milli...
Vascularized liver-heart on-a-chip modeling antibody-mediated rejection and tolerance of allografts
PROJECT SUMMARY Organ transplantation remains the best and most cost-effective clinical solution for end-stage organ failure; however, it comes with the burden of lifelong immunosu...
Describing the emotional environment of the infant from 6 to 17 months
Describing the Emotional Environment of the Infant, from 6 to 17 Months Understanding and recognizing emotions is critical for children’s social interactions, enabling them to appr...
Leveraging pediatric state-specific functional brain network dynamics to predict developmental outcomes
PROJECT SUMMARY Determining accurate models of the developing brain’s functional architecture during the first two years of life has potential prognostic value for maturation miles...
Behavioral Research on Acculturation and moderating and mediating Variables Observed Specifically among Latinos: BRAVOS
Behavioral Research on Acculturation and moderating and mediating Variables Observed Specifically among Latinos: BRAVOS Abstract/Project Summary: Low-income Latino children are dis...
Assessing the role of Federally Qualified Health Centers in advancing quality and equity of care for pregnant and postpartum Medicaid enrollees
PROJECT SUMMARY Low-income pregnant and postpartum patients (PPP), especially persons of color, experience significant inequities in quality of care and health outcomes across the...
Advancing non-invasive brain stimulation: A CompreheNSive Study of Temporal Interference Mechanisms (CNS-STIM)
PROJECT SUMMARY/ABSTRACT Temporal Interference (TI) is an innovative non-invasive brain stimulation technique that holds great promise. It utilizes high-frequency electrical curren...
Antiviral Discovery in Microbial Eukaryotes
Project Summary Antiviral systems are critical to the survival of their host. They protect from virally induced morbidity and mortality across all known domains of life and play an...
Implementing the NIMH Clinical Pathway in Rural Appalachian School-Based Health Clinics
Rural Appalachian youth are at disproportionately high risk for suicide and experience significant barriers to health care access. School-Based Health Centers (SBHCs) have the pote...
Developmental pyrethroid exposure in the Shank3 mutant prairie vole as a 2-hit model for neurodevelopmental disorder risk
Project Summary The prevalence of autism and other neurodevelopmental disorders (NDDs) is at an all-time high, with 17% of children diagnosed with a developmental disability and 1...
Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP
PROJECT SUMMARY/ ABSTRACT Rates of bacterial sexually transmitted infections (STIs) are rising globally, demanding innovative interventions beyond the scope of current efforts to p...
Establishing PREMISE: A PrEP Epidemiology, Modeling, and Surveillance System
Abstract To reach Ending the Epidemic (ETE) targets, we will need consistent national HIV pre-exposure prophylaxis (PrEP) data to describe patterns of use, and to understand which...
Epigenetic modification of HIV-1 Cap
Project summary Basic research opens the door to better understand, treat, and ultimately prevent existing and emerging public health threats. NIAID has prioritized fundamental res...