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99,167 grants found
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Developing a Novel Analytical Toolbox to Tackle Multifaceted Statistical Challenges in Analyzing Post-Fracture Recovery Trajectories in Older Adults with ADRD
Project Summary/AbstractOlder adults diagnosed with ADRD are up to three Ɵmes more likely than cogniƟvely intact older adults to sustain a hip fracture, and paƟents with ADRD have...
Impact of juvenile social isolation on maturation of frontal circuit and SUD-relevant behavior
Early life social experiences, especially social deprivation, can have long-lasting consequences on risk for developing psychiatric disorders including Substance Use Disorders (SUD...
Neurocognitive, genetic and socioenvironmental influences on a developmental precursors to addiction: A cross-species study
Project Summary/Abstract Early environmental and genetic influences exert significant effects on risk for Substance Use Disorders (SUDs). Understanding precursors to SUDs, such as...
Consequences of Incarceration on Health, Age-Related Conditions, and Risk Factors for ADRD
PROJECT SUMMARY Alzheimer's disease and related dementias (ADRD) disproportionately affect Black and Hispanic adults, attributable, in part, to disparities in socioeconomic st...
Cerebral tau deposition and comorbid cerebrovascular disease across the Alzheimer's disease continuum in Mexican Americans
SUMMARY: Alzheimer's disease (AD) and related dementias (ADRD) disease burden is anticipated to affect diverse ethnic and racial groups disproportionately with the most stagge...
The Impact of Sex and Hippocampal Angiotensin II on Alzheimer's Disease
Abstract Alzheimer’s disease (AD) is the most common form of dementia in the aged population. An ongoing conundrum within the AD field is that despite women with dementia outnumber...
Precision pharmacogenomics and Indigenous research: A novel approach to tobacco cessation efficacy in American Indian communities
PROJECT SUMMARY: The leading cause of health inequities and premature death in the United States (US) is smoking. Creating equitable access to smoking cessation aids and supporting...
Neural Mechanisms of miss- and touch-guided sensorimotor corrections
PROJECT SUMMARY When you reach for an apple and miss, you immediately make corrective submovements to make contact. And after contact, precise touches at your fingers reshape your...
Undiagnosed Obstructive Sleep Apnea in Primary Care Clinics
Obstructive sleep apnea (OSA) is a major public health problem that is commonly seen in primary care clinics where a majority of outpatient office visits occur. Prior studies sugge...
Role of Peripheral Insulin Resistance and Inflammation in Alzheimer’s Disease
Insulin resistance is a common shared feature in Alzheimer’s disease (AD) and metabolic dysfunction-associated steatotic liver disease (MASLD), and recent studies have found that M...
Vibrotactile stimulation of the larynx for refractory chronic cough
PROJECT SUMMARY/ABSTRACT Chronic cough affects millions of people in the US and around the world, and has a significant negative impact on quality of life, especially when it is re...
Preliminary imaging studies evaluating the vesicular acetylcholine transporter as a treatment target in major depressive disorder
The cholinergic hypothesis of major depressive disorder (MDD) is based on extensive evidence that excess brain acetylcholine (ACh) contributes to both the onset and worsening of MD...
Duocentric Social Networks and Alcohol-Related Intimate Partner Aggression among Couples from Low-Income Communities
PROJECT SUMMARY/ABSTRACT Intimate partner aggression (IPA) is a prevalent public health concern that has been tied to numerous negative consequences. Alcohol use is a well-establis...
Host-Dependent Mechanisms that Guide the Longitudinal Dynamic of Sites of SIV Integration
Project Summary HIV integrates into the host genome and enters a state of latency, enabling infected cells to escape immune recognition and clearance. Eliminating the latent reserv...
Assessment of strategies for targeting transcriptional co-activators in colorectal cancer
Project Summary: PGC-1 family proteins (PGC-1α, PGC-1β, and PPRC1) are transcriptional coactivators that act as central hubs to coordinate diverse cellular inputs to promote the tr...
Connexin 43 drives glioblastoma cancer stem cells through a WNK1 signaling axis
ABSTRACT Glioblastoma, the most common primary malignant brain cancer, remains uniformly fatal despite current standard of care consisting of maximal safe surgical resection follow...
Neural Mechanisms of Menstrual Cycle Effects on ADHD and Cognition
ABSTRACT Attention-Deficit/Hyperactivity Disorder (ADHD) is increasingly recognized as a serious and debilitating problem in adolescent and adult females, with impairment and comor...
IMPACT-ADRD: Investigating the Multi-omics Perturbations Associated with Complex Environmental Toxicants and their Contribution to Alzheimer's Disease and Related Dementias
Abstract Increased risks of chronic illnesses, including Alzheimer’s Disease and related dementias (AD/ADRD), have been linked to exposures to ambient air pollution, particularly f...
Human iPSC model of Cerebro-Vascular Interactions in ADRD
We propose to generate and validate a novel model that incorporates human cerebral cortical neurons and glia, vascular endothelial cells, neural crest pericytes and microglia from...
The Contribution of Structural Racism to the Long-Term Effects of Natural Disaster on Behavioral Health Outcomes (SALENDO)
ABSTRACT Black and Latinx people in the United States (US) suffer disproportionately high levels of substance use and mental health disorders. Further, racial and ethnic minoritize...