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99,167 grants found
Showing 301 – 320 of 99,167 grants
Endothelial Reactive Oxygen Species in Exercise Metabolism
PROJECT SUMMARY Exercise is a powerful strategy to improve skeletal muscle metabolism that can both prevent and reverse disease. However, the complex signaling that drives the imme...
The Impacts of Adverse Provider Conditions on Provider Bias and Health Disparities
Project Summary Healthcare disparities that adversely affect patients from racial and ethnic minoritized groups are often attributed to provider level factors such as implicit bias...
The Heart Outcomes for Pregnancy Expectations Study
Project Abstract/Summary The US not only has the highest rate of maternal mortality in the developed world but is the only country in which this rate is rising. It is also notoriou...
Multicomponent mhealth interventions for healthcare providers and the community to increase cancer screening in India
PROJECT SUMMARY/ABSTRACT Given that a large proportion of cancers are detected at a late stage in India, approaches to increase screening uptake could have a significant impact on...
The impact of antiretroviral therapy on fetal immune system development in SIV-exposed rhesus macaques
SUMMARY The use of antiretroviral therapy (ART) in pregnant women living with HIV is an effective way to prevent mother-to-child transmission. However, HIV-exposed, but uninfected...
Development of tools for analyzing cell-cell communication using spatial transcriptomic data
PROJECT SUMMARY Biological tissues, consisting of different cells, specialize in a group of processes and functions through coordinated activities of many cells. Cell-cell communic...
Cultivating Recovery: A Pilot Study of Digital Contingency Management for Co-occurring Opioid and Alcohol Use Disorder
Project Summary/Abstract Opioid agonist therapies (i.e. buprenorphine and methadone) are first-line treatments for opioid use disorder (OUD) and overdose prevention. Sequalae of al...
3D Human neurocircuits to determine the role of microglia in AUD and Alzheimer's neuronal pathology
Abstract: 3D human neurocircuits to determine the role of microglia in AUD and Alzheimer’s neuronal pathology. Altered neuronal metabolism, neuronal activity, and neurodegeneration...
Human Trisome Project - Latin America Network
PROJECT SUMMARY. People with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display a unique clinical profile across the lifespan. Early on, children with DS...
The Infant Down Syndrome Brain and Behavior Study
ABSTRACT Down syndrome (DS), the most common genetic cause of intellectual disability, accounts for ~30% of all moderate-to-severe IDD cases, with ~5,500 new individuals diagnosed...
Flexible piezo film intravascular ultrasound arrays on guidewires and catheters
Coronary heart disease and peripheral artery disease are the leading causes of atherosclerotic morbidity along with stroke. More than a million percutaneous coronary and peripheral...
Computational tools for illuminating the dark matter of the human virome
Project Summary As greater understanding of the important role that the human microbiome plays in human health has unfolded it is increasingly recognized that there is a vast and u...
Imaging of macrophage trafficking with ultrasound
Project Summary Imaging of macrophage trafficking can reveal important molecular, cellular, and functional characteristics of the host tissue and support the discovery of new bioma...
Impact of benzalkonium chloride on gut microbiome and gut-liver interactions
Benzalkonium chlorides (BACs) are widely used antimicrobials in disinfecting products, medical products, and food processing industries, suggesting humans may be exposed chronicall...
ACL Reconstruction Rehabilitation with Exercise and Psychological Support
PROJECT SUMMARY Anterior cruciate ligament (ACL) rupture is a common knee injury in sports that is usually surgically treated with ACL reconstruction. Most patients expect to resum...
Genicular Artery Embolization for Reducing Pain in Medically Refractory Mild to Moderate Osteoarthritis: A Double-Blind, Randomized Sham-Controlled Pilot Study
PROJECT SUMMARY/ABSTRACT Knee osteoarthritis (KOA) is a pervasive and debilitating disease, affecting over 15 million people in the US alone. Symptoms include pain, stiffness, and...
Unraveling the Genomic Causes for Unsolved Leukodystrophy Patients by HiFi-GS
SUMMARY Leukodystrophies (LD) are a group of rare genetic disorders preferentially affecting cerebral white matter (myelin) in previously healthy children and is associated with ex...
Assessing Differential Dyadic Mechanisms of Black and White Women’s Sexual Functioning
Project Summary/Abstract Female sexual function (FSF) refers to how desire, arousal, orgasm, pain, pleasure, and satisfaction are experienced by women. Female sexual dysfunction (F...
Pathogenic exosomes during herpes zoster mediate increased vascular dementia risk
Project Summary: Vascular dementia is the second most common cause of dementia. Therapies aim to control risk factors (e.g. hypertension, hyperlipidemia, and diabetes mellitus) to...
Let's Talk: Overcoming barriers to the uptake of cascade screening through a stakeholder-informed online intervention
ABSTRACT The impact of genetic testing for disease prevention hinges on cascade screening, the process of systematically identifying and testing relatives in families with a geneti...