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99,167 grants found
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A Cross-scale analysis of cell-ECM adhesion in early spinal column development
The tailbud is the posterior growth zone of the post-gastrulation vertebrate embryo containing the neural and mesodermal progenitors of the spinal column. The posterior neural tube...
Chemical biology tools for illuminating cannabinoid signaling pathways in opioid use disorder.
Project Summary/Abstract The opioid epidemic is a persistent public health crisis in the United States and abroad, historically dominated by the misuse of prescription opioids and...
Multiplex meningeal lymphatic activation for Alzheimer’s disease
PROJECT SUMMARY/ABSTRACT There is an unmet medical need to develop new therapeutic strategies for Alzheimer’s disease (AD). Brain lymphatic vasculature is (re)discovered at the int...
The MIGHT Trial - An Exploratory Clinical Trial of IVIG in anti-HMGCR ImmuneMediated Necrotizing Myopathy
PROJECT SUMMARY Anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune mediated necrotizing myopathy (IMNM) is an increasingly recognized, severe subset of autoimmune myopath...
Small molecule inhibitors of CAPON-induced tau aggregation
PROJECT SUMMARY/ABSTRACT: Alzheimer's disease (AD), the most common type of dementia worldwide, is a rapidly increasing public health concern. There is an urgent need for the...
Choline-Related Polymorphisms in Fetal Alcohol Spectrum Disorders
Prenatal Alcohol Exposure (PAE) is a leading cause of cognitive disabilities known as Fetal Alcohol Spectrum Disorders (FASD). Interventions that ameliorate PAE’s impact are a high...
Image-based algorithms for remote cesarean surgical site infection diagnoses in diverse populations
Project Summary/Abstract Post-cesarean surgical site infections (SSIs) contribute to maternal morbidity and mortality globally; as rates of cesarean delivery increase, so will the...
Alleviation of chemotherapy-induced cardiovascular toxicity
ABSTRACT Many cancer drugs increase cardiovascular (CV) events, including hypertension, thrombosis, and cardiomyopathy. Damaged endothelial cells (ECs) caused by chemotherapy can t...
Modeling fetal lung development in congenital diaphragmatic hernia
PROJECT SUMMARY/ABSTRACT Congenital diaphragmatic hernia (CDH) is polygenic condition in which the fetal intestines and liver herniate into the thoracic cavity, resulting in lung c...
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH)
Project Summary/Abstract With the advent of modern antiretroviral therapy, life expectancy in people with HIV (PWH) now approaches that of the general population. Nonetheless, PWH...
Human‐specific vulnerabilities and compensatory adaptations to age‐related stressors in selectively vulnerable midbrain dopaminergic neurons
PROJECT SUMMARY The evolutionary expansion of the brain along the primate lineage involved unequal scaling of brain regions, with telencephalon size increasing dramatically more th...
RBC Effects on Neutrophil Activation and Phenotypes in Sickle Cell Disease
Project Summary/Abstract Increasing evidence suggests that activated neutrophils play a critical role in promoting vaso-occlusion and morbidity in sickle cell disease (SCD). Multip...
Coordinating Center for Primate Aging Research
SUMMARY The Tulane National Primate Research Center (TNPRC), California National Primate Research Center (CNPRC), and Baylor College of Medicine (BCM) present a unique combination...
Cellular and circuit adaptations contributing to the incubation of oxycodone craving
PROJECT SUMMARY Recently, opioid use and dependence has increased to epidemic levels. A prominent contributor to this trend is oxycodone, (Oxy), a semisynthetic opioid analgesic an...
Impact of new tobacco product design and synthetic additives on use initiation and preference behavior
The tobacco industry has been rapidly introducing products with novel designs and constituents, in response to regulatory interventions, to maintain nicotine dependence in people w...
Quality Measures to Advance Suicide Prevention and Care Across Health Systems
PROJECT SUMMARY / ABSTRACT Suicide accounted for >48,000 deaths in the United States (US) in 2021. The annual rate has increased by >34% in the last 20-years. Suicide prevent...
Dissecting the thermosensory biology of soil-transmitted parasitic nematodes
PROJECT SUMMARY Soil-transmitted parasitic nematodes infect over a billion people around the world and can cause devastating and sometimes fatal illness. Despite this massive healt...
The molecular basis of ferrosome organelle biogenesis and its impact on host-microbe interactions
SUMMARY Clostridioides difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of nosocomial and antibiotic-associated intestinal infections in the Unit...
Understanding the role of the blood vascular system and endothelial cells in early thymus regeneration after cytotoxic treatments using novel intravital imaging techniques
PROJECT SUMMARY Hematopoietic cell transplantation (HCT) remains an important treatment for hematologic malignancies such as multiple myeloma, lymphoma, acute leukemias, and myelod...
Establishing if Music Engagement is a Protective Factor in Adolescent Substance Use Using Existing Longitudinal, Genetic, and Environmental Datasets
PROJECT SUMMARY / ABSTRACT. Substance use disorders affect millions of Americans, with substance use often beginning in adolescence. There is a pressing need to identify targets fo...