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99,167 grants found
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Evaluating Neurocognitive Complications of Type 1 Diabetes (T1D) and Potential Risk and Protective Factors in Pre-Pubertal Children- New York University Clinical Center
Project Summary Children with type 1 diabetes (T1D) have an increased likelihood of mild cognitive dysfunction and altered brain development compared to healthy children, which can...
iSMART: intelligent Social risk Management in AD/ADRD paTients
ABSTRACT People living with dementia (PLWD) from racial-ethnic minoritized groups and socioeconomically disadvantaged environments are more likely to face barriers to diagnosis, ca...
Improving needs among older adults: the ICUconnect 2 primary palliative care RCT
Abstract Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable acros...
Racial and ethnic disparities in patient outcomes and intra-arrest resuscitation practices for in-hospital cardiac arrest
ABSTRACT The overarching goal of this R21 grant proposal is to evaluate racial and ethnic disparities in patient outcomes, racial and ethnic differences in the three key intra-arre...
Improving screening and access to treatment for depression in care partners of people living with dementia
Depression affects up to 34% of care partners (CP) of people living with Alzheimer’s disease/Alzheimer’s disease-related dementia (PLWD) each year and despite the expansion of trea...
Cyst induction and growth in ADPKD
Abstract: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the world’s most common life-threatening genetic diseases. Mutations in the genes PKD1 and PKD2 account for...
EQUITY IN ACCESS TO ALZHEIMER'S DISEASE PHARMACOLOGIC TREATMENT FOR AFRICAN AMERICAN AND WHITE PATIENTS IN ALABAMA A MIXED METHODS STUDY TO INFORM RECOMMENDATIONS EquAAL
PROJECT SUMMARY New disease modifying drugs, like lecanemab, if used equitably across populations disproportionately affected byAlzheimer’s disease (AD), like African Americans (AA...
SIV reservoirs dynamics during aging
Abstract The advancement of combinational antiretroviral therapy (cART) converts the life of people living with HIV (PLWH) to manageable diseases. However, due to the persistence o...
HIV-Associated Lung Disease: The Role of Nasal Mucosal Immunity and Microbiome
PROJECT SUMMARY/ABSTRACT People living with HIV (PLWH) are at heightened risk for chronic lung diseases. The mechanisms underlying this risk are poorly understood. Viral infections...
The Objective Identification of Bruising in Children using Diffuse Reflectance Spectroscopy
PROJECT SUMMARY The objective of this study is to examine the validity of reflectance spectroscopy as a diagnostic tool for objectively diagnosing bruising in infants and children....
Quantitative Ultrasound Imaging of the Neonatal Brain
Abstract Brain injuries affect millions of infants each year and may cause irreversible cell death. Visualizing cell death in their brains is challenging. There is a need for non-i...
Use of a digital memory prosthetic to support autobiographical memory in down syndrome
PROJECT SUMMARY Down syndrome is the most common genetic cause of intellectual disability (Hawli et al., 2009), associated with significant developmental delays (Carr, 1988) and a...
Microscale Enzymatic Remodeling of Molecular Glycosylation
Asparagine-linked glycans are involved in complex regulation and signaling, and play a critical role in disease. This is because small differences in this post translational modifi...
Adapting the CHATO Communication Intervention for Diverse Nursing Home Communities
Dementia is most prevalent in Black and Hispanic older adults who are increasingly cared for in nursing homes (NHs). Staff shortages and lack of dementia care skills limit care qua...
Interpersonal behavioral synchrony in virtual and in-person dyadic conversation
PROJECT SUMMARY/ABSTRACT Human dyadic social communication entails a rich repertoire of expression, including not only face expression (and gaze), but also acoustics (prosody and p...
The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome
PROJECT SUMMARY/ABSTRACT Down syndrome (DS) is a developmental genetic condition caused by trisomy of human chromosome 211-6. DS occurs in approximately 1 in 600-1000 live births a...
Investigating the Role of Adipose Senescent Cells in Cognitive Function and Alzheimer's Disease Progression
Investigating the Role of Adipose Senescent Cells in Cognitive Function and Alzheimer's Disease Progression Abstract Alzheimer's disease (AD) is an incurable neurodegener...
Neuroimaging and clinical Endpoints With High-dimensional analysis Of Pathological Endophenotypes in TBI (NEW-HOPE-TBI)
Project Summary/AbstractAlzheimer’s disease and related dementias (ADRDs) are highly prevalent, devastating to patients and their loved ones, and encompass a diversity of etiologie...
Robot-based Information and Support to Enhance Alzheimer's Caregiver Health (RISE)
Project Summary/Abstract The burden of caring for persons with Alzheimer's disease and related dementias (PwADRD) often falls on unpaid caregivers, usually family members or f...
The opposing effects of matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration
ABSTRACT Young skeletal muscle displays remarkable resilience following an acute injury event, evidenced by a robust regenerative response and functional recovery. In contrast, eve...