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ERAD-STING Crosstalk in Microglia: Unraveling the Pathogenesis of Alzheimer's Disease
ERAD-STING Crosstalk in Microglia: Unraveling the Pathogenesis of Alzheimer's Disease ABSTRACT Alzheimer’s disease (AD) is an age-dependent progressive neurodegenerative disea...
Maternal Fetal Metabolic Disruption in Prenatal Alcohol Exposure
Project Summary Despite public health efforts to reduce prenatal alcohol exposure (PAE), 11.7% of pregnant women in the U.S. consume alcohol and 3.9% binge drink. PAE can lead to g...
The Role of Striatal Astrocytic Dopamine D2 Receptor Signaling in the Pathogenesis of LRRK2-Mediated Parkinson's Disease
Mutations on the LRRK2 gene, which increase the encoded protein's kinase activity, are common genetic causes of familial Parkinson's disease (PD). Noncoding variants at t...
Elucidating the Link Between Oral Health and Dementia Subtypes: A Multifaceted Study on the Biological Pathways and Social Determinants
Project Summary/Abstract As the U.S. population ages, the number of individuals living with dementia is rapidly increasing, making the identification of modifiable risk factors mor...
Clonal Hematopoiesis Aging Resiliency Mechanisms
Project Summary With age, dividing cells acquire DNA mutations. A small number of these somatic mutations confer a selective advantage leading to clonal outgrowth. In blood, this p...
CH in Aging and Exceptional Longevity
Project Summary Clonal Hematopoiesis (CH) is characterized by somatic mutations originating from a few hematopoietic stem cell clones. CH is well known to be an age associated phen...
Metabolic regulation of the stem cell niche
PROJECT SUMMARY/ABSTRACT Adult stem cells constitute a group of progenitor cells capable of tissue regeneration during life through the ability to both self-renewal and produce spe...
Cognitive, structural and functional impact of new onset type 1 diabetes on the brain of young children: Understanding risks and protective factors
An increasing body of data show the brain is a target of diabetes complications. We and others have investigated the impact of type 1 diabetes (T1D) in the developing brain in chil...
Determinants of Neurocognitive Complications in T1D
Project Summary Children with type 1 diabetes (T1D) suffer from subtle cognitive impairments and structural alterations in the brain. These impairments progress with age and may ev...
Neurocognitive Complications of Pediatric Type 1 Diabetes: Identifying Modifiable Risk and Protective Factors
PROJECT SUMMARY Children with type 1 diabetes (T1D) have small but significant deficits in neurocognitive functioning compared to their peers without diabetes, especially in the ar...
Attention and memory contributions to the maintenance of binge eating
Attention and memory contributions to the maintenance of binge eating PROJECT SUMMARY/ABSTRACT Binge eating (BE) is a transdiagnostic symptom of multiple eating disorders, includin...
Risk and Protective Factors for Neurocognitive Development in Type 1 Diabetes
Project Summary/Abstract Type 1 diabetes (T1D) in childhood may cause neurocognitive deficits which worsen over time. Declines in cognitive function may lead to suboptimal T1D mana...
Investigations of drug encapsulation in polymer nanoparticles: Training undergraduate students in multidisciplinary research
Abstract For several decades nanoparticle formulations of molecules used for diagnostics and/or therapy have been intensively developed to improve and control their bioavailability...
Mapping Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors
PROJECT SUMMARY The pathophysiology of cognitive dysfunction in prepubertal children with Type 1 Diabetes Mellitus (T1DM) is not understood. It is likely that hyperglycemia, hypogl...
Membrane cholesterol homeostasis in human brain cells derived from iPSCs
Alzheimer’s disease (AD), a major form of dementia, starts with synaptic dysfunction and progresses to massive neurodegeneration. Mutations of amyloid precursor protein (APP) that...
UNITED: Understanding neurocognitive outcomes in Type 1 diabetes: Modifiable risk and protective factors in diverse youth
PROJECT SUMMARY Growing evidence suggests that individuals with Type 1 diabetes mellitus (T1D) are at risk for cognitive dysfunction over time, with approximately 28% of middle-age...
Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) Biostatistics Research Center (BRC)
Summary Type I diabetes (T1D) is one of the most common chronic diseases in childhood. Sequelae of pediatric T1D include neurocognitive dysfunction in attention, psychomotor speed,...
Neurocognitive Effects of Type 1 Diabetes in Young Children: Indiana University Clinical Center
PROJECT SUMMARY Many individuals living with Type 1 diabetes (T1D) experience significant cognitive impairments. These impairments are more common in people diagnosed in early chil...
Longitudinal Evaluation of Neurocognitive Complications in Pediatric Type 1 Diabetes Across Multi-Ethnic Groups—Exploring Risk and Protective Factors
PROJECT SUMMARY Our multidisciplinary team endeavors to address critical knowledge gaps regarding the impact of type 1 diabetes (T1D) on neurocognitive outcomes among a diverse pop...
Mechanisms underlying the neuroprotective effect of nasal administration of anti-CD3 in AD mouse models
In Alzheimer’s disease (AD), danger signals including dead neurons, dystrophic axons, tau and Ab alter the functional phenotype of microglia from a homeostatic (M0) to a neurodegen...