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99,167 grants found
Showing 3,101 – 3,120 of 99,167 grants
Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patients
Project Summary/Abstract Allogeneic hematopoietic cell transplantation (HCT) was developed in the 1950’s as a treatment option for life- threatening malignant and non-malignant dis...
Defining TBK1-associated autophagy networks in neurons
Project Summary/Abstract Frontotemporal dementia (FTD) is characterized by the unrelenting loss of cortical neurons that manifests clinically as devastating changes in the behavior...
The cross-talk between a-Synucleinopathies and T cell immunity in ADRD
Project Summary α-Synucleinopathies includes Dementia with Lewy Body (DLB), Parkinson's Disease with Dementia (PDD), and Alzheimer's Disease with Lewy Body Dementia (AD-L...
Distinguishing α-Synuclein S129 Phosphorylation in Health and Lewy Body Dementia
α-Synuclein (αS) is an abundant brain protein that regulates neurotransmission. αS is also implicated in Parkin- son’s disease (PD), PD with dementia (PDD), dementia with Lewy bodi...
TRANSFORM - Transforming the evidence base on estimating prevalence of opioid use disorder and expanded access to interventions to prevent drug related deaths: an international data linkage study
PROJECT ABSTRACT The scale of opioid harms in the US and globally requires urgent action to improve efforts to reduce such harms. Evidence on the number of people with opioid use d...
Electrophysiological and molecular imaging of early AD progression
PROJECT SUMMARY Research on Alzheimer’s disease has strongly focused on pathological alterations such as plaques and tangles, and has overlooked the functional consequences of neur...
Neurobehavioral and Psychosocial Predictors of Health Risk Behaviors in Adolescence and Young Adulthood
PROJECT SUMMARY Young adulthood is a developmental period during which health risk behaviors (HRBs) (e.g., substance use) peak, but the factors that lead to sustained addiction are...
Extracellular matrix in vertebrate hematopoietic stem cell specification
(PLEASE KEEP IN WORD, DO NOT PDF)Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Hematopoietic s...
Rare sperm screening and retrieval with a domain-adaptive deep learning-enabled microwell system.
Project Summary Reproductive challenges are a growing concern worldwide, marked by a 50% decline in fertility rates over the past 50-years. Approximately 10% of couples face infert...
A cross-sectional and longitudinal study of gut microbiota in Parkinson's disease
Project Summary/Abstract The majority of the PD patients have a long history of constipation before the onset of the motor symptoms of PD. Abnormal gut microbiota (dysbiosis) and i...
Discovery of synthetic and endogenous ligands for orphan GPCR GPR156
G Protein coupled Receptors (GPCRs) regulate every aspect of human physiology. However, the endogenous ligands activating ~100 GPCRs are still unknown, hence they are named orphan...
PRICE- Alcohol: Planning the Regional Implementation of a Culturally Adapted Brief Intervention for Alcohol for Tanzanian Emergency Departments
ABSTRACT Alcohol use is rapidly increasing in low- and middle-income countries, where it is inexpensive, readily available, poorly regulated, and there are few resources devoted to...
Pathogenic Role of APP E590D in Alzheimer’s Disease.
Project Summary Our preliminary studies show that the APP E590D variant, identified in two AD patients’ brains, substantially induces more Aβ than APP-WT in vitro cell line and pri...
Pairing tVNS with motor skill training in older adults
Summary Motor function is often compromised by neurological injury, such as stroke and even healthy aging. Decline in motor skills reduces the quality of life and independence in a...
Identifying molecular mechanisms of responding to gravity using the nematode C. elegans
ABSTRACT Impaired ability to respond to the earth’s gravitational field and loss of balance results in high risk of falls with adverse consequences for one’s health, quality of lif...
Mechanisms Underlying Regulation of PLCbeta by heterotrimeric G proteins
Phospholipase C b (PLCb) enzymes increase intracellular calcium in response to diverse extracellular signals, regulating numerous processes including cell proliferation and surviva...
Utilizing senolytics to enhance the response to exercise in cachectic mice
Project Summary. Skeletal muscle mass and function are key determinants of an individual’s healthspan and are tightly correlated with both physical and metabolic health. In cancer...
Development of Tetrahydrocannabivarin as a Treatment for Smokers
ABSTRACT Tobacco use is the leading cause of preventable death and disease in the United States. The majority of smokers report the desire to quit smoking; however only 3-5% of una...
Early life pain and its modulation by socioenvironmental factors: Implications for substance misuse
ABSTRACT Roughly 10% of births in the United States are premature and typically involve a stay in the Neonatal Intensive Care Unit (NICU), where infants endure painful procedures a...
Targeting Lung Fibrosis Using Epigenetic Therapy
PROJECT SUMMARY Pulmonary fibrosis is a complex disease that limits lung function through development of collagen-rich scar tissue. Although there are currently two FDA-approved th...