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99,167 grants found
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Xylazine exposure and transitions to low-frequency injecting and injection cessation
Project Summary: We propose a two-year qualitative study that will characterize transitions to low-frequency injecting and injection cessation among people using xylazine-adulterat...
Deciphering the immunogenicity of cell death using systematic genetic tools
Project Summary Professional phagocytes, including macrophages and dendritic cells, engulf approximately 200 billion dead cells per day in humans. The vast majority of dead cells a...
Exploiting the microbiota-stromal cell axis for microbiota-targeted medicine
PROJECT SUMMARY The development of successful vaccines is a significant achievement in public health. However, vaccines exhibit varying efficacy across different individuals and po...
Testing tailored text reminders and financial incentives to enhance antidepressant adherence for depressed adults in primary care
ABSTRACT Improving outcomes for adult depression in primary care is a leading health care priority and antidepressants are a cornerstone of evidence-based treatment. However, patie...
Whole Genome Sequencing of N. gonorrhoeae from Non-Culture Based Clinical Specimens to Surveil for Emerging Resistance
Project Summary Drug-resistant Neisseria gonorrhoeae (NG) is listed as one of the 5 Urgent Threats in the US by the CDC and one of 6 pathogens determined as high priority by WHO. M...
Astrocyte-neuron regulation of autophagy and lysosomal pathways in proteotoxic stress associated with alpha-synucleinopathies
A unifying pathology of age-related neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclero...
Identifying the Role of Oral Health in Heart Disease through Integration of GWAS-by-Subtraction Genomic-Structural Equation Modeling with the Method of Instrument Variables
Project Summary Our proposed project will build upon previous research which has shown an association between oral health and systemic health, including the relationship between he...
A soft electronics-enabled smart microneedle patch for neck pain management
Project Summary Neck pain is a common cause of disability with 33.6 million disability-adjusted life years in the U.S. The cost for neck pain due to production loss and sick leave...
Targeted Modulation of Longevity-Associated Genes Using Antisense Oligonucleotides
Project Summary Aging is a major risk factor for many chronic diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases, as well as for geriatric...
Development of peptoid-based barcodes for in vivo high-throughput screening of targeted nucleic acid delivery
PROJECT SUMMARY / ABSTRACT The proposed project aims to deliver a research tool that supports accurate and resource- efficient biodistribution studies involving a library of gene-e...
Tau-RNA crosstalk: Alternative Poly-Adenylation (APA) Regulation in Alzheimer's Disease
Alzheimer's disease (AD) is a devastating degenerative brain disorder and the most prevalent form of dementia, affecting millions worldwide. Given its significant impact on pu...
Cumulative Effects of Pre-recession and the Great Recession Precarity on Black-White Disparities in Health Biomarker Trajectories and All-cause Mortality Among Older Workers
Racial disparities among older adults in diabetes, cardiovascular disease (CVD), and mortality have widened, in part due to economic recessions such as the Great Recession (2008-20...
Adaptation of Family Check-Up Online in the Latinx Community to Reduce Youth Substance Use.
7. PROJECT SUMMARY Latinx people are the largest and fastest growing minority population in the U.S., yet most lack access to culturally responsive preventative interventions to re...
Experiences of Parents Seeking Emergency Care for Injured Children with Special Health Care Needs
Children and youth with special health care needs (CYSHCN)—which include children with chronic conditions such as Asthma, Autism, Depression, Down Syndrome, or Spina Bifida—are at...
Development of Measures to Screen for Financial Hardship in Alzheimer's Disease and Dementia
PROJECT ABSTRACT/SUMMARY Alzheimer's Disease and related dementias (AD/ADRD) are common and debilitating conditions. Financial hardship, a multidimensional construct of financ...
Investigating the mechanism by which orexins contribute to sex differences in cognitive flexibility after stress
Project Summary and Abstract Stress-related psychiatric disorders, such as post-traumatic stress disorder (PTSD) and depression, are serious mental illnesses that occur twice as fr...
BAI Adhesion-GPCRs: Key Regulators of Synapse Development and Plasticity in Health and Disease
PROJECT SUMMARY/ABSTRACT Development fashions 1011 neurons in the brain that form 1014 tightly regulated synaptic connections which un- derlie cognition and emotion. Numerous neuro...
Direct and Indirect Effects of Disasters on Drug-Related Outcomes
Project Summary Brought on by anthropogenic causes, disasters have increased in number, intensity, costliness, and human impact, including public health. Over the same period, drug...
Exploring the Rescue Strategy for Female NEXMIF Haploinsufficiency via X Chromosome Reactivation
Abstract: We previously confirmed that loss of the X-linked gene NEXMIF results in social behavior deficits and intellectual disability.Although only male NEXMIF patients were init...
Age-equivalent neurons from MCI patients to investigate early determinants of AD
SUMMARY Alzheimer's disease (AD) affects over 50 million people worldwide. In the vast majority of patients, AD develops sporadically in the absence of any known etiology othe...