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99,167 grants found
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An Automated Frailty Scoring System for Lung Transplantation Based on Bio-Geo-Composition
Abstract: Lung transplantation is a life-saving treatment for individuals suffering from end-stage lung diseases. The number of lung transplants is increasing annually, and over 50...
Developing an Ontology for Dental Care-Related Fear and Anxiety: Toward an Understanding of Problems in Dental Care Utilization
Project Summary/Abstract Dental care-related fear, anxiety, and/or phobia (hereafter, DFA) traditionally refers to the emotional, behavioral, and/or physical responses that may occ...
Dynamics of RNA regulation and noncanonical translation between cell states
Project Summary The genetic landscape of patient samples has illustrated a vast array of potential diagnostic and clinical biomarkers through profiling of chromosomal rearrangement...
Addressing the Impacts of Structural Racism on Race Inequities in Health: A Focus on Mass Incarceration, Housing, and their Intersection
This multi-level mixed methods study will analyze the implications for racial health equity of policies that undergird structural racism (SR) in the domains of mass incarceration (...
Write From The Start
ABSTRACT Peer-reviewed publications are essential for successful careers in biomedical research. The development of strong writing skills is critical for early stage investigators...
Defining HIV evolution at the innate immune interface
PROJECT SUMMARY HIV remains a major global health burden, in large part because of its massive evolutionary potential to rapidly evolve escape mutations even from multi-drug therap...
Adaptive immunity to Aspergillus during neutropenia
PROJECT SUMMARY/ABSTRACT Aspergillus species are ubiquitous molds that cause clinical disease in hosts with impaired immunity or abnormal mucosal defenses. In particular, individua...
Multifaceted Regulation of Mineralocorticoid Receptor Transcriptional Activities
Project Summary Transcription factors (TFs) recognize specific DNA sequences and recruit coregulators including chromatin modification enzymes to direct gene expression. The human...
Elucidating Context-Specific FERONIA Receptor Kinase Signaling
Elucidating Context-Specific FERONIA Receptor Kinase Signaling Project Summary/Abstract Understanding how cellular signaling pathways achieve specificity is an important question i...
Noncanonical roles of Bim in heat shock-induced cell death
PROJECT SUMMARY/ABSTRACT Severe hyperthermia (heatstroke) is due to a failure of thermoregulation that can lead to cell death in various tissues resulting in multisystem organ fail...
IDEAL-XAI: Advancing Explainable AI to Identify Early Driver Events of Alzheimer's Disease
Project Summary Alzheimer’s disease (AD) lacks effective treatment, primarily due to our limited scientific understanding of the early cellular pathways leading to end-stage pathol...
Understanding the relationship between precocious neuronal differentiation and early-onset neurodegeneration
Several common mechanisms have been implicated in neurodegenerative diseases. The accumulation of misfolded proteins, microtubule disruption, mitochondrial dysfunction, upregulatio...
Investigating the combined role of APOE4 and ketogenic diets in Alzheimer's disease
Abstract Diet and nutrition influence our cognitive abilities, how our brains age, and vulnerability to neurodegeneration. However, the interaction of diet with the human brain is...
Translation of overprinted non-canonical open reading frames from alternative transcript variants
This project describes a class of recently discovered human genes: internal open reading frames (iORFs) that overlap annotated protein coding sequences in alternative reading frame...
Attentional Resilience in Older Adults
In delirium and Alzheimer’s disease (AD), which increase the risk for each other, patients suffer deficits in executive functions, including attentional control. There is a critica...
Interactions between diverse brain cell types drive Aicardi-Goutieres neuropathology
ABSTRACT Aicardi Goutières (AGS) is a severe autoinflammatory disease that predominantly affects the brain, leading to severe cognitive and physical disabilities. Although this dis...
Understanding spatial representations in rat orbitofrontal cortex
Project summaryGrowing evidence suggests that adaptive value representations in the brain are critical to flexible decision making. Inflexibledecisions are a hallmark of a range of...
Individual functional brain mapping for biomarker discovery in Alzheimer's
PROJECT SUMMARY: Alzheimer’s disease (AD) affects over 6 million Americans, and its incidence is projected to double by 2050 due to an aging population. In the fight against AD, th...
Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease diagnosed postmortem in people exposed to repetitive head impacts (RHI) from football and other contact sports...
Discovery of novel tau proteoforms as biomarker candidates for AD and PSP
Project Summary Abstract Early detection and diagnosis of Alzheimer’s disease (AD) or Alzheimer’s disease and related dementias (ADRD) have been important goals of the National Pla...