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Understanding protein turnover alterations in physiological brain aging
Understanding protein turnover alterations in physiological brain aging ABSTRACT In mammals, physiological aging is associated with multiple molecular changes that lead to loss of...
Molecular mechanisms of pathological aging of human brain and adipose and their inter-organ communication
Project Summary Advanced age is a major risk factor for age-related diseases such as type 2 diabetes (T2D), Alzheimer’s disease (AD) and many others. It remains elusive what aging...
The Impact of the COVID19 Pandemic on the Hispanic/Latinx Birth Outcome Advantage
Project Summary This project focuses on whether the COVID-19 pandemic has put the well-established Hispanic infant health advantage in peril. The U.S. Hispanic population has been...
Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
The nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe, lethal hemorrhagic disease. CCHFV is the most prevalent tickborne virus that causes human disease and is...
The lysosomal fasting response in intestinal stem cells and cancer
PROJECT SUMMARY Fasting improves organismal health and tissue homeostasis in part by enhancing stem cell activity. In addition, stem cells serve as a cell-of-origin in multiple can...
The Impact of the Accountable Care Organization Realizing Equity, Access, and Community Health (ACO REACH) Program on Outcomes and Equity for Patients with Alzheimer's Disease and Related Dementias
ABSTRACT Health inequities in older adults along racial and sociodemographic lines are persistent and pervasive in the United States. These inequities are particularly profound amo...
Identifying tandem repeat expansion-mediated mechanisms of autism-risk genes
Project Summary Autism spectrum disorder (ASD) is a set of neurodevelopmental conditions that affect communication and social interactions with restricted interests and repetitive...
Realizing BRAVE-EM for Nanoscale Multicolor Imaging in Biology: Biological Real-space Absorption Visualization by photoEmission Electron Microscopy
Project Summary/Abstract Imaging cells and tissue labeled with fluorescent molecules and proteins is critical in biological research, enabling visualization of the locations of spe...
Decoding endocrine and paracrine communication through mammokines
Project Summary Interactions among different organs are pivotal in developing pathological conditions like obesity and type 2 diabetes. Substantial research efforts have been direc...
Reprogramming intestinal immunity in preterm neonates to prevent and cure necrotizing enterocolitis
Project Summary/Abstract Necrotizing enterocolitis (NEC) is a severe, often fatal intestinal disease of prematurity. Mortality rates approach 50% if surgery is required to resect n...
Piloting a patient navigator program to facilitate uptake and persistence with evidence-based weight loss interventions
Abstract Millions of adults in the U.S. with overweight or obesity would like to improve their health and quality of life via weight loss, yet utilization of evidence-based weight...
Memory in the enteric nervous system
Project summary The formation of memories is central to the human condition. It enables learning and the accumulation of knowledge overthe lifespan, and it allows using the past in...
Evaluating real-world effectiveness of tele-buprenorphine: A mixed-methods study to develop clinical guidance
Project Summary/Abstract Buprenorphine is a life-saving treatment for people with opioid use disorder (OUD), yet only 1 in 5 people with OUD receive this medication. Telehealth-del...
Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA Metabolism
Abstract Propionic acidemia (PA) is a rare metabolic disease due to PCCA or PCCB mutations. PA could develop various complications even with dietary restriction. While gene therapy...
Mechanisms of aryl hydrocarbon receptor control of eosinophilic esophagitis
PROJECT SUMMRAY Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus partially mediated by epithelial barrier breach, resulting in harmless antigens penetrating t...
Mechanisms of hypoxia-mediated memory impairment in an animal model of acute respiratory failure in preterm survivors
Summary Due to advances in neonatal care, most preterm infants no longer develop cerebral palsy from hypoxic-ischemic white matter injury (WMI). However, up to 50% develop gray mat...
The Role of the Complement Pathway in Alzheimer's Disease
Abstract The development of -amyloid (A) pathology in Alzheimer’s disease (AD) is accompanied by hyperactivation of microglia and neuroinflammation. Genome-wide association studi...
Transmembrane Protein 178 as a Novel Endogenous Inhibitory Mechanism in Asthma
PROJECT SUMMARY Asthma is characterized by chronic, non-resolving lung inflammation; however, there are endogenous inhibitory mechanisms that normally promote the resolution of lun...
Identifying optimal dietary patterns for postpartum cardiovascular disease prevention
PROJECT SUMMARY Cardiovascular disease has declined dramatically in all US adults except young women, whose rates remain stagnant. Young women who are Black or low-income carry the...
Prebiotic diet intervention to enhance the microbiome and immunotherapy response in melanoma
PROJECT SUMMARY Treatment with immune checkpoint inhibitors (ICI) has been revolutionary in melanoma and other cancers. However, only a subset of patients will have durable respons...